socs3
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  • Official Full Name
  • suppressor of cytokine signaling 3
  • Background
  • This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
  • Synonyms
  • SOCS3; suppressor of cytokine signaling 3; CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3; STAT-induced STAT inhibitor 3; cytokine-inducible SH2 protein 3;
Cat.#:SOCS3-1526RTag:His
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat SOCS3 Protein (1-225 aa), His-tagged
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Cat.#:SOCS3-3895HTag:Trx & His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOCS3, Trx & His tagged
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Cat.#:SOCS3-5093HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOCS3, His-tagged
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Cat.#:SOCS3-6938HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Suppressor Of Cytokine Signaling 3, GST-tagged
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Cat.#:SOCS3-6940HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human Suppressor Of Cytokine Signaling 3, Myc-DDK-tagged
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Cat.#:SOCS3-6941HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human Suppressor Of Cytokine Signaling 3, GST-tagged
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Cat.#:Socs3-26MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Socs3 protein, His-tagged
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Cat.#:Socs3-1797RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Socs3 protein, His-tagged
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Cat.#:SOCS3-5665RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SOCS3 Protein
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Cat.#:SOCS3-4402RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SOCS3 Protein, His-tagged
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Cat.#:SOCS3-6168CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SOCS3
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Cat.#:SOCS3-1580HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SOCS3 293 Cell Lysate
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Involved Pathway

SOCS3 involved in several pathways and played different roles in them. We selected most pathways SOCS3 participated on our site, such as Ubiquitin mediated proteolysis, Osteoclast differentiation, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOCS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
FZR1; TCEB1B; CDC23; ANAPC2; UBA2; BIRC7; CUL4A; UBE2IA; RHOBTB1; COP1
Osteoclast differentiation
TREM2; FOSB; PIK3CA; NFKB2; TNF; STAT1; MAP3K7; FCGR4; FCGR2C; TEC
Jak-STAT signaling pathway
IFNG1-2; IFNA10; PRP2; IL24; IL23; IL6; CRFB4; RAF1B; CISHB; IL15RA
TNF signaling pathway
IL1B; PGAM5; RIPK1; RPS6KA5; MLKL; MAP2K1; CXCL10; MMP14; AKT2; MAP3K14
Insulin signaling pathway
MTOR; EIF4E2RS1; PRKAB2; TRIP10A; CALML3; PPP1R3CA; PPP1CBL; MAPK8; PRKAR1AB; HK2
Prolactin signaling pathway
SHC3; MAPK1; SOCS1; PIK3CD; ESR1; MAPK10; SLC2A2; SOCS7; NRAS; KRAS
Adipocytokine signaling pathway
CPT1A; ADIPOR1B; PRKAA1; RXRG; IKBKB; ADIPOQB; PPARGC1A; TNFRSF1A; ADIPOQ; PCK2
Type II diabetes mellitus
INSR; MAPK3; TNF; MAPK1; SOCS4; SOCS1; INS1; INS2; PIK3R1; HK1
Insulin resistance
GFPT1; PPARGC1B; PPP1R3A; PYGMA; PYGB; MGEA5; CREB3L3L; SLC2A2; PIK3R5; IRS1
Non-alcoholic fatty liver disease (NAFLD)
PRKAG2; NDUFA3; NDUFB1; RAC1; PIK3CA; NDUFA4; NDUFS1; FAS; NDUFA1; UQCRC2
Hepatitis C
IFIT1; TRAF3; CLDN18; CLDN16; MAPK10; AKT2; CLDN20; IKBKB; RAF1; CLDN14
Influenza A
IL12B; IFNA10; RNASEL; TNFRSF1A; NFKB1; TMPRSS4; TMPRSS13; IFNA14; HLA-DPA1; PIK3CA
Herpes simplex infection
LOC100033925; CUL1; BLB1; SRSF5B; TLR9; HNRPK; PVRL2; IFNA13; STAT1; PVRL1

Protein Function

SOCS3 has several biochemical functions, for example, protein binding, protein kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOCS3 itself. We selected most functions SOCS3 had, and list some proteins which have the same functions with SOCS3. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein ALAS2; HOXB9; MIF4GD; SOX4; CPSF7; SMOC1; RTN4RL2A; PML; RPS6KB1; TNK1
Function protein kinase inhibitor activity
Related Protein SOCS1; CD36; SOCS9; GMFG; WNK1; NCK1; SH3BP5; SOCS5B; TAOK3; TRIB2

Interacting Protein

SOCS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOCS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOCS3.
PTK2; YES1; KIAA1958; MAP1S; TRDN; SH2D2A; RASA1

SOCS3 Related Articles

Kim, G; Ouzounova, M; et al. SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model. ONCOGENE 34:671-680(2015).
Cianciulli, A; Dragone, T; et al. IL-10 plays a pivotal role in anti-inflammatory effects of resveratrol in activated microglia cells. INTERNATIONAL IMMUNOPHARMACOLOGY 24:369-376(2015).