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SOCS4

Official Full Name

suppressor of cytokine signaling 4
Overview

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Synonyms

SOCS4; suppressor of cytokine signaling 4; SOCS7, suppressor of cytokine signaling 7; SOCS-4; SOCS-7; suppressor of cytokine signaling 7; SH2 domain containing SOCS box protein; SOCS7; DKFZp686J1568;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SOCS4-344H	Recombinant Human SOCS4 Protein, His-tagged	E.coli	His	Inquiry
Human	SOCS4-345H	Recombinant Human SOCS4 Protein, His-tagged	E.coli	His	Inquiry
Human	SOCS4-1666HCL	Recombinant Human SOCS4 cell lysate		N/A	Inquiry
Rhesus Macaque	SOCS4-4403R	Recombinant Rhesus monkey SOCS4 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	SOCS4-4219R	Recombinant Rhesus Macaque SOCS4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	SOCS4-4219R-B	Recombinant Rhesus Macaque SOCS4 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	SOCS4-6262Z	Recombinant Zebrafish SOCS4	Mammalian Cell	His	Inquiry
Chicken	SOCS4-4238C	Recombinant Chicken SOCS4	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
SOCS4 Related Articles
SOCS4 Related Signal Pathway

SOCS4 involved in several pathways and played different roles in them. We selected most pathways SOCS4 participated on our site, such as Insulin signaling pathway, Jak-STAT signaling pathway, Kit Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOCS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Insulin signaling pathway	PYGMA;PRKAA2;AKT1;PDPK1;G6PCA.2;CALML5;PTPN1;GYS1;CALML3
Jak-STAT signaling pathway	AOX1;LIFR;IL7R;CSF3R;SOCS6;PTPN2;Ifna11;Il2;SOCS5B
Kit Receptor Signaling Pathway	STAP1;GRAPA;SPRED2B;GRB7;SOCS4;DOK1;DOK1B;PTPRUB;PTPRU
Prolactin signaling pathway	MAPK13;MAPK8;SIRPA;GALT;PIK3CB;CSH;SHC1;KRAS;SHC4
Type II diabetes mellitus	IKBKB;INS-IGF2;IRS4;MAFA;SLC2A4;PKM2;HK3;SOCS1;PIK3R1

SOCS4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOCS4 itself. We selected most functions SOCS4 had, and list some proteins which have the same functions with SOCS4. You can find most of the proteins on our site.

Function	Related Protein
protein binding	LIG3;FAM111A;RAB2B;EIF1AY;KIAA0947;C6;KCTD9;PPP3CB;FAM115A

SOCS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOCS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOCS4.

GRB2; PIK3R3; RBP7; PINK1; FRS3; ppapdc2; LECT1; TNK2

Rutz, S; Kayagaki, N; et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. NATURE 518:-(2015).

Guo, H; Wang, Y; et al. Platelet Factor 4 Limits Th17 Differentiation and Ischaemia-Reperfusion Injury After Liver Transplantation in Mice. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:129-134(2015).