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SOD1

  • Official Full Name

    superoxide dismutase 1, soluble

  • Overview

    The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    SOD1; superoxide dismutase 1, soluble; ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer; superoxide dismutase [Cu-Zn]; SOD, soluble; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase, cystolic; epididymis secretory protein Li 44;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bovine
  • Cattle
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Horse
  • Human
  • Macaca Fascicularis
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Sheep
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Kidney tissue
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • yeast
  • Yeast
  • C
  • His
  • Myc
  • DDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|MBP
  • His|SUMO|Myc
  • His|T7
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SOD1-326H Active Recombinant Human Superoxide Dismutase 1, Soluble, His-tagged E.coli His
Human SOD1-103H Active Recombinant Human SOD1, low endotoxin E.coli N/A 154 AA
Human SOD1-8H Active Recombinant Human Superoxide Dismutase yeast N/A
Human SOD1-1432H Active Recombinant Human SOD1 E.coli N/A
Human SOD1-104H Active Recombinant Human SOD1 E.coli N/A 154 AA
Human SOD1-05H Active Recombinant Human Superoxide Dismutase 1 / SOD1 protein, Tag Free E.coli N/A
Human SOD1-1570H Active Recombinant Human SOD1 Protein, Animal Free, Beta-lactam Antibiotics Free E.coli
Human SOD1-200H Recombinant Human Superoxide Dismutase 1 E.coli N/A
Human SOD1-6992H Recombinant Human SOD1, GST-tagged E.coli GST Full length
Human SOD1-328H Recombinant Human SOD1 protein, His/MBP-tagged E.coli His/MBP
Human SOD1-170H Recombinant Human SOD1 Protein, His-tagged E.coli His Ala2-Gln154
Human SOD1-30341TH Recombinant Human SOD1 E.coli N/A
Human SOD1-1635H Recombinant Human Superoxide Dismutase 1, Soluble, GST-tagged E.coli GST
Human SOD1-1037H Recombinant Human SOD1 Protein E.coli N/A 1-154aa
Human SOD1-1161H Active Recombinant Human SOD1 protein, His-tagged E.coli His Ala 2 - Gln 154
Human SOD1-04H Recombinant Human SOD1 protein E.coli N/A 153
Human SOD1-642H Recombinant Human SOD1 protein, His-tagged E.coli His 189
Human SOD1-1576HCL Recombinant Human SOD1 293 Cell Lysate HEK293 N/A
Human CAB11605RH Rabbit Monoclonal Antibody to Human Superoxide Dismutase 1, Soluble Rabbit N/A
Human SOD1-2069H Recombinant Human SOD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SOD1-67H Recombinant Human SOD1 Protein Insect Cell
Human SOD1-028H Recombinant Human SOD1 Protein E.coli 154
Human SOD1-1158H Recombinant Human SOD1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SOD1-2069H-B Recombinant Human SOD1 Protein Pre-coupled Magnetic Beads HEK293
Human SOD1-070H Recombinant Human SOD1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human SOD1-029H Recombinant Human SOD1 Protein E.coli 154
Human SOD1-1180HFL Recombinant Full Length Human SOD1 Protein, C-Flag-tagged Mammalian cells Flag
Human SOD1-6332H Recombinant Human SOD1 Protein (Met1-Gln154), N-His tagged E.coli N-His Met1-Gln154
Human SOD1-2495H Recombinant Human SOD1 protein(71-140 aa), C-His-tagged E. coli C-His 71-140 aa
Mouse Sod1-2023M Recombinant Mouse Sod1 protein, His-tagged E.coli His Ala2~Gln154 (Accession # P08228)
Mouse SOD1-15749M Recombinant Mouse SOD1 Protein Mammalian Cell His
Mouse SOD1-8568M-B Recombinant Mouse SOD1 Protein Pre-coupled Magnetic Beads HEK293
Mouse SOD1-8568M Recombinant Mouse SOD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Sod1-5524M Recombinant Mouse Sod1 protein, His-tagged Yeast His 2-154aa
Mouse Sod1-6040M Recombinant Mouse Sod1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Sod1-2026R Recombinant Rat Sod1 protein, His-tagged E.coli His Ala2~Gln154 (Accession # P07632)
Rat SOD1-5666R Recombinant Rat SOD1 Protein Mammalian Cell His
Rat SOD1-5325R Recombinant Rat SOD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SOD1-5325R-B Recombinant Rat SOD1 Protein Pre-coupled Magnetic Beads HEK293
Rabbit SOD1-2027R Recombinant Rabbit SOD1 protein, His-tagged E.coli His Ala2~Pro153 (Accession # P09212)
Bovine CED026 Active Bovine Superoxide Dismutase (SOD), High Purity >95% Kidney tissue
Bovine SOD1-101B Active Native Bovine SOD N/A
Bovine SOD1-102B Active Native Bovine SOD, modified N/A
Cattle SOD1-2020C Recombinant Cattle SOD1 protein, His-tagged E.coli His Ala2~Lys152 (Accession # P00442)
Cynomolgus SOD1-956C Recombinant Cynomolgus SOD1 Protein, His-tagged E.coli His
Cynomolgus SOD1-957C Recombinant Cynomolgus SOD1 Protein, His-tagged HEK293 His
Cynomolgus Monkey SOD1-699C-B Recombinant Cynomolgus Monkey SOD1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey SOD1-699C Recombinant Cynomolgus Monkey SOD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Horse SOD1-2021H Recombinant Horse SOD1 protein, His & T7-tagged E.coli His/T7 Ala2~Pro154 (Accession # P00443)
Macaca Fascicularis SOD1-01H Recombinant Cynomolgus SOD1 Protein, His-tagged HEK293 His 159
Rhesus Macaque SOD1-4405R Recombinant Rhesus monkey SOD1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SOD1-4221R Recombinant Rhesus Macaque SOD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SOD1-4221R-B Recombinant Rhesus Macaque SOD1 Protein Pre-coupled Magnetic Beads HEK293
Sheep SOD1-2024S Recombinant Sheep SOD1 protein, His & T7-tagged E.coli His/T7 Ala2~Pro152 (Accession # P09670)
Zebrafish sod1-1373Z Recombinant Zebrafish sod1 Protein, His-SUMO/MYC-tagged E.coli His/SUMO/Myc
Zebrafish SOD1-8884Z Recombinant Zebrafish SOD1 Mammalian Cell His
Pig SOD1-2025P Recombinant Pig SOD1 protein, His & T7-tagged E.coli His/T7 Ala2~Gln153 (Accession # P04178)
Chicken SOD1-2022C Recombinant Chicken SOD1 protein, His & T7-tagged E.coli His/T7 Ala2~Cys154 (Accession # P80566)
Chicken SOD1-6621C Recombinant Chicken SOD1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SOD1 Related Articles
  • SOD1 Related Research Area

SOD1 involved in several pathways and played different roles in them. We selected most pathways SOD1 participated on our site, such as Peroxisome, Amyotrophic lateral sclerosis (ALS), Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PeroxisomePEX10;ABCD4;ACSL3B;GSTK1;ACSL3;PRDX1;ACSL1A;ACSL5;IDH2
Amyotrophic lateral sclerosis (ALS)TOMM40L;BAX;PPP3R1;NEFH;BID;PPP3CA;GRIN1;GRIN2D;MAP2K3
Huntingtons diseaseCOX4I2;ATP5D;NDUFS2;POLR2J3;NDUFV2;BBC3;CREB3L3;DCTN2;NDUFA6
Prion diseasesSOD1;C8G;PRKACG;IL1A;C1QC;C6;C8A;HSPA1A;NCAM2

SOD1 has several biochemical functions, for example, Rac GTPase binding, chaperone binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOD1 itself. We selected most functions SOD1 had, and list some proteins which have the same functions with SOD1. You can find most of the proteins on our site.

Function Related Protein
Rac GTPase bindingARHGEF2;PAK7;PAK2;EPS8;SOD1;ARHGAP4A;SRGAP2B;RAB7A;DVL1
chaperone bindingDLST;PFDN6;HSPD1;ATP1A2;TBCD;DNLZ;HSPE1;DNAJB6;TRP53
copper ion bindingLOXL3A;TYRP1;SCO1;APOA4;S100A12;S100V2;HIST2H3A;SNAI3;AOC1
identical protein bindingDYNLT3;ATL2;CLDN8;SMAD1;USP2;PRPS2;ROBO1;RAD51;CLDN4
protein bindingDBF4B;MAF;PRKD2;GTF2I;HILPDA;ZNF155;UBE2G2;NEK2;NLRX1
protein homodimerization activityPRTFDC1;APOE;BCL2A1A;CEACAM1;NFKB1;AGR2;HSD17B4;PRPS2;KCNN2
protein phosphatase 2B bindingSOD1;AKAP1;ATP2B4;AKAP5;PPP3CB;MYOZ2;SLC9A1;BAD
superoxide dismutase activitySOD1;SOD3A;NQO1;CCS;PRNPA;SOD2
zinc ion bindingPDLIM3B;TRIM50;CA6;ARHGEF2;LNX2B;ZNF253;ISL2B;TRIM6;ZDHHC20A

SOD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOD1.

Chga; Chgb; DYNC2LI1; RAC1; BAG3

Malaspina, A; Puentes, F; et al. Disease origin and progression in amyotrophic lateral sclerosis: an immunology perspective. INTERNATIONAL IMMUNOLOGY 27:117-129(2015).
Xu, GL; Ayers, JI; et al. Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice. HUMAN MOLECULAR GENETICS 24:1019-1035(2015).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
Are there potential therapeutic strategies targeting SOD1 for disease treatment? 01/23/2022

Therapeutic strategies may involve modulating SOD1 activity or expression to mitigate oxidative stress-related damage.

What is the primary biological function of SOD1 in cells? 01/03/2022

SOD1 acts as an antioxidant, converting superoxide radicals to hydrogen peroxide and oxygen.

What are the genetic implications of mutations in the SOD1 gene? 03/01/2021

Mutations in SOD1 can result in loss or gain of function, contributing to disease development.

How is SOD1 implicated in neurodegenerative diseases? 02/09/2020

SOD1 mutations are implicated in Amyotrophic Lateral Sclerosis (ALS), leading to neurodegeneration.

In which cellular compartments is SOD1 primarily located? 11/14/2019

SOD1 is primarily located in the cytoplasm and mitochondrial intermembrane space.

What role does SOD1 play in maintaining cellular redox balance? 08/27/2019

It helps maintain cellular redox balance, protecting cells from oxidative damage.

How does SOD1 contribute to the cellular antioxidant defense system? 02/27/2019

It plays a crucial role in cellular defense against oxidative stress.

Customer Reviews (3)

Write a review
Reviews
11/15/2022

    Worked perfectly, no problems.

    10/09/2020

      Quick delivery, fantastic product.

      10/02/2020

        Reliable results every time.

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