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SORCS2

Official Full Name

sortilin-related VPS10 domain containing receptor 2
Overview

SorCS2 is a family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. It is noted that all mammalian VPS10 domains carry an N-terminal signal peptide for translocation into the endoplasmic reticulum. The greatest similarity
Synonyms

SORCS2; sortilin-related VPS10 domain containing receptor 2; VPS10 domain-containing receptor SorCS2; KIAA1329; VPS10 domain receptor protein;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SORCS2-732H	Active Recombinant Human SORCS2 Protein, His-tagged	Mammalian cells	His	Ser70-Gly1078	Inquiry
Human	SORCS2-4103H	Recombinant Human SORCS2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	SORCS2-4103H-B	Recombinant Human SORCS2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
SORCS2 Related Articles
SORCS2 Related Research Area

SORCS2 involved in several pathways and played different roles in them. We selected most pathways SORCS2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SORCS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

SORCS2 has several biochemical functions, for example, neuropeptide receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SORCS2 itself. We selected most functions SORCS2 had, and list some proteins which have the same functions with SORCS2. You can find most of the proteins on our site.

Function	Related Protein
neuropeptide receptor activity	NPFFR1L1;NPFFR2.1;MCHR1;KISS1RA;KISS1R;NPFFR1L3;SORCS1;HCRTR1;NPBWR1

SORCS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SORCS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SORCS2.

NGF; Ngf; Ngf; NGFR; NTF3; BDNF; Ngfr

Reitz, C; Tosto, G; et al. Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP). TRANSLATIONAL PSYCHIATRY 3:-(2013).

He, YQ; Fang, ZY; et al. Sortilin-related VPS10 domain containing receptor 1 and Alzheimer's disease-associated allelic variations preferentially exist in female or type 2 diabetes mellitus patients in southern Han Chinese. PSYCHOGERIATRICS 12:215-225(2012).

VPS10P-domain Family