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SOX5

Official Full Name

SRY (sex determining region Y)-box 5
Overview

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms

SOX5; SRY (sex determining region Y)-box 5; transcription factor SOX-5; L SOX5; MGC35153; Sex determining region Y box 5; SOX 5; SOX 5 protein; SOX5 protein; SOX5_HUMAN; SRY (sex determining region Y) box 5; SRY box 5; Transcription factor SOX 5; Transcription factor SOX5; OTTHUMP00000239955; OTTHUMP00000239958; OTTHUMP00000239959; OTTHUMP00000239960; OTTHUMP00000239961; OTTHUMP00000239962; OTTHUMP00000239963; L-SOX5;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Sf9 Insect Cell

Tag

DDK
His
Myc
N/A
N
T7|His

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SOX5-143H	Recombinant Human SOX5 protein, T7/His-tagged	E.coli	T7/His		Inquiry
Human	SOX5-2884H	Recombinant Human SOX5, His-tagged	E.coli	His	C-term-375aa	$319 / 25ug
Human	SOX5-30693TH	Recombinant Human SOX5, His-tagged	E.coli	His		Inquiry
Human	SOX5-107H	Recombinant Human SOX5 Protein, DDK-tagged	Sf9 Insect Cell	DDK		Inquiry
Human	SOX5-1558HCL	Recombinant Human SOX5 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SOX5-659H	Recombinant Human SOX5 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	SOX5-6337H	Recombinant Human SOX5 Protein (Met14-Pro284), N-His tagged	E.coli	N-His	Met14-Pro284	Inquiry
Human	SOX5-2720H	Recombinant Human SOX5 Protein, His-tagged	E.coli	N-His	Met1-Pro284	Inquiry
Mouse	Sox5-6057M	Recombinant Mouse Sox5 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	SOX5-3397Z	Recombinant Zebrafish SOX5	Mammalian Cell	His		Inquiry
Chicken	SOX5-1204C	Recombinant Chicken SOX5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SOX5 Related Research Area

SOX5 involved in several pathways and played different roles in them. We selected most pathways SOX5 participated on our site, such as Endochondral Ossification, Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Endochondral Ossification	ADAMTS5;RUNX2A;DDR2;COL2A1;PTH;COL10A1;PTHLH;MMP13;NKX3-2
Neural Crest Differentiation	OLIG2;SOX10;HEY2;LHX1;TCF4;FOXD3;CTBP2;PRTG;PHOX2B

SOX5 has several biochemical functions, for example, RNA polymerase II transcription factor activity, sequence-specific DNA binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX5 itself. We selected most functions SOX5 had, and list some proteins which have the same functions with SOX5. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II transcription factor activity, sequence-specific DNA binding	JUNBA;FLI1A;ATF4B2;NPAS4A;TRP53;TWIST1;SOX8A;FOXL1;ZNF446
protein binding	XRCC5;TCL1A;ALPP;POU5F1;FLRT3;JAGN1;SEMA6A;SLC5A1;ATP6V0D1
protein heterodimerization activity	TYR;DLG4B;JAM2;FLOT2;CA;IL12B;ATF4;TAF4B;UGT1A6
transcription factor activity, sequence-specific DNA binding	HEY2;NKX3;ZNF256;DBPA;SCAND3;NFE2L3;PURBB;VAX2;KLF4
transcription regulatory region DNA binding	CTNNB1;ATF6B;TCF7L1B;ZNF613;NKX2-1;PHB;ZNF335;ZFP821;FOXH1

SOX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX5.

ARID5A; g2xkq0_human; CRX; tax; LMO2; LMO1; PRR20C

Chondrogenesis Markers

Neural Stem Cell Transcription Factors

Transcription Factors in the Akt Pathway