SOX9
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Official Full Name
SRY (sex determining region Y)-box 9
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Overview
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008] -
Synonyms
SOX9; SRY (sex determining region Y)-box 9; CMD1; SRA1; CMPD1; transcription factor SOX-9; SRY-related HMG-box, gene 9; SRY (sex-determining region Y)-box 9 protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- SOX9 Related Research Area
SOX9 involved in several pathways and played different roles in them. We selected most pathways SOX9 participated on our site, such as cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | PPP1CC;ARAP3;PDE4B;TNNI3;GRIA3;RAP1B;PIK3R1;HTR1F;CREB5 |
SOX9 has several biochemical functions, for example, bHLH transcription factor binding, beta-catenin binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX9 itself. We selected most functions SOX9 had, and list some proteins which have the same functions with SOX9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| bHLH transcription factor binding | IKZF4;ISL1;SIRT1;USF2;FOXH1;USF1;SP1;MAP3K10;EP300 |
| beta-catenin binding | APC2;CD2AP;TAX1BP3;FAM123B;BTRC;EP300;PARK2;DACT3;PROP1 |
| chromatin binding | GABPA;HIF1AB;GATA4;NUPR1;MLH3;SIX1;ELK1;SIRT6;TCF7L2 |
| core promoter sequence-specific DNA binding | REST;MEOX1;SIRT1;MTA1;NRF1;NR4A3;NRIP1;SOHLH2;SP1 |
| enhancer binding | FOXH1;MESP1;ARNT;RAI1;LEF1;SP1;TCF12;AHR;TCF3 |
| enhancer sequence-specific DNA binding | MYT1;KLF6A;FOXN4;YY1;GATA1;LDB1;GATA4;HMGB2;GATA5 |
| pre-mRNA intronic binding | RBM4;RBM41;PRPF8;SOX9;RNPC3;EP300;HNRNPA2B1 |
| protein binding | CHUK;OSTA;KRT8;RNF126;PUF60;CENPO;TPD52L3;PARK7;STYK1 |
| protein heterodimerization activity | ABCG1;MAPK4;SYT14;HER1;HIST1H3D;BNIP3;H3F3C;BTBD11A;SMAD3 |
| protein kinase A catalytic subunit binding | PRKAR1B;RYR2;PRKAR2A;PRKAR2B;GSK3B;PJA2;EZR;KCNQ1;SOX9 |
| protein kinase activity | MAK;PRKG1A;CSNK1G2B;GUCY2F;GC3;CAMK2G1;LRRK2;WEE2;SLKA |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | CEBPB;RELA;NFIX;TFAP4;PDX1;USF2;PROX1;MEF2A;MYOG |
| transcription factor activity, sequence-specific DNA binding | POU3F2;FOXF2A;NFATC2;NR2F2;SNAPC5;IKZF4;ZNF202;PRDM2;GLI4 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | FOXC2;ETV4;NCOA3;ELF3;ETV6;ATOH1;SP1;PGR;EPAS1 |
SOX9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX9 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX9.
ATP6V1H; dsdna_dadt:dadt
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