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SPAST

  • Official Full Name

    spastin

  • Overview

    This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4.
  • Synonyms

    SPAST; spastin; spastic paraplegia 4 (autosomal dominant; spastin) , SPG4; ADPSP; FSP2; KIAA1083; FSP 2; Spastic paraplegia 4; SPG 4; SPG4; spastic paraplegia 4 protein; spastin);

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Danio rerio (Zebrafish) (Brachydanio rerio)
  • Gallus gallus (Chicken)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • Xenopus laevis (African clawed frog)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SPAST-2901H Recombinant Human SPAST, GST-tagged E.coli GST 79-278aa
Human SPAST-2082H-B Recombinant Human SPAST Protein Pre-coupled Magnetic Beads HEK293
Human SPAST-5187H Recombinant Human SPAST Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SPAST-2416H Recombinant Human SPAST Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SPAST-2082H Recombinant Human SPAST Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SPAST-2537H Recombinant Human SPAST protein, His-tagged E.coli His 79-278 aa
Human SPAST-369HFL Recombinant Full Length Human SPAST Protein, C-Flag-tagged Mammalian cells Flag
Mouse SPAST-15819M Recombinant Mouse SPAST Protein Mammalian Cell His
Mouse SPAST-8609M Recombinant Mouse SPAST Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Spast-6075M Recombinant Mouse Spast Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SPAST-8609M-B Recombinant Mouse SPAST Protein Pre-coupled Magnetic Beads HEK293
Rat SPAST-5685R Recombinant Rat SPAST Protein Mammalian Cell His
Rat SPAST-5344R-B Recombinant Rat SPAST Protein Pre-coupled Magnetic Beads HEK293
Rat SPAST-5344R Recombinant Rat SPAST Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL176BF Recombinant Full Length Bovine Spastin(Spast) Protein, His-Tagged E.coli expression system His Full Length (1-614)
Danio rerio (Zebrafish) (Brachydanio rerio) RFL18501DF Recombinant Full Length Danio Rerio Spastin(Spast) Protein, His-Tagged E.coli expression system His Full Length (1-570)
Gallus gallus (Chicken) RFL931GF Recombinant Full Length Chicken Spastin(Spast) Protein, His-Tagged E.coli expression system His Full Length (1-613)
Mus musculus (Mouse) RFL10255MF Recombinant Full Length Mouse Spastin(Spast) Protein, His-Tagged E.coli expression system His Full Length (1-614)
Rattus norvegicus (Rat) RFL19823RF Recombinant Full Length Rat Spastin(Spast) Protein, His-Tagged E.coli expression system His Full Length (1-581)
Sus scrofa (Pig) RFL36314SF Recombinant Full Length Pig Spastin(Spast) Protein, His-Tagged E.coli expression system His Full Length (1-613)
Xenopus laevis (African clawed frog) RFL16855XF Recombinant Full Length Xenopus Laevis Spastin(Spast) Protein, His-Tagged E.coli expression system His Full Length (1-600)
Zebrafish SPAST-12168Z Recombinant Zebrafish SPAST Mammalian Cell His
Chicken SPAST-2741C Recombinant Chicken SPAST Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

SPAST involved in several pathways and played different roles in them. We selected most pathways SPAST participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SPAST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

SPAST has several biochemical functions, for example, ATP binding, alpha-tubulin binding, beta-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPAST itself. We selected most functions SPAST had, and list some proteins which have the same functions with SPAST. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPIK3C2G;SCN8A;GRK5;KHK;PEX1;UBE2G1B;IDH3G;CKMA;PRKDC
alpha-tubulin bindingARL8B;PACRG;CAV3;C9orf24;PROL1;HDAC6;SLC6A2;WASH;FAM110C
beta-tubulin bindingARL8A;GABARAPL1;SNCA;RANBP10;VAPB;HTT;TBCD;ARL8B;PEX14
microtubule bindingZFP207;CCDC88A;KATNA1;ZNF207;TXNDC3;TERF1;CRYAB;NDEL1;LC3
microtubule-severing ATPase activityATAD1A;KATNAL2;ATAD1;ATAD1B;SPAST;FIGNL1;FIGN;KATNAL1
protein bindingIL1R2;SMC4;POLR1B;EAF2;SLC4A1;FAM128B;TTI1;ZNF223;ISOC2

SPAST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPAST here. Most of them are supplied by our site. Hope this information will be useful for your research of SPAST.

q8cl55_yerpe; ALB; GAS2L3; AURKB

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