spast
Share
  • Official Full Name
  • spastin
  • Background
  • This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4.
  • Synonyms
  • SPAST; spastin; spastic paraplegia 4 (autosomal dominant; spastin) , SPG4; ADPSP; FSP2; KIAA1083; FSP 2; Spastic paraplegia 4; SPG 4; SPG4; spastic paraplegia 4 protein; spastin)
Cat.#:SPAST-2416HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SPAST Protein, MYC/DDK-tagged
+Inquiry
Cat.#:SPAST-2901HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SPAST, GST-tagged
+Inquiry
Cat.#:SPAST-15819MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SPAST Protein
+Inquiry
Cat.#:SPAST-5685RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SPAST Protein
+Inquiry
Cat.#:SPAST-2741CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SPAST
+Inquiry
Cat.#:SPAST-12168ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SPAST
+Inquiry

Protein Function

SPAST has several biochemical functions, for example, ATP binding, alpha-tubulin binding, beta-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPAST itself. We selected most functions SPAST had, and list some proteins which have the same functions with SPAST. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ALK; TOR1L1; EPHA3; PIP5K1A; AURKC; NLK; ACTR3B; NLRP2; CNTN1B; ACTR8
Function alpha-tubulin binding
Related Protein ARL8A; SNCA; PACRG; ARL8B; RACGAP1; NCALD; SPAST; SLC6A2; CAV3; BBS4
Function beta-tubulin binding
Related Protein GABARAPL2; TBCD; PEX14; GABARAPL1; SLC6A2; BBS4; HTT; UXT; TRPV4; ADNP
Function microtubule binding
Related Protein KIAA1128; MAP1S; MTAP1A; CCDC88A; S100A8; CDK5RAP2; CRIPT; TERF1; PRNP; KATNB1
Function microtubule-severing ATPase activity
Related Protein KATNAL1; KATNAL2; FIGN; FIGNL1; ATAD1; SPAST; ATAD1A; ATAD1B
Function protein binding
Related Protein NR1H3; HBD; FEM1B; PTPN1; RUVBL2; FAM158A; GSS; ZNF394; NPM2; KIF4A

Interacting Protein

SPAST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPAST here. Most of them are supplied by our site. Hope this information will be useful for your research of SPAST.
q8cl55_yerpe; ALB; GAS2L3; AURKB