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SPG20

Official Full Name

spastic paraplegia 20 (Troyer syndrome)
Overview

This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).
Synonyms

SPG20; spastic paraplegia 20 (Troyer syndrome); spartin; KIAA0610; TAHCCP1; trans-activated by hepatitis C virus core protein 1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SPG20-2900H	Recombinant Human SPG20, GST-tagged	E.coli	GST	1-350aa	$319 / 25ug
Human	SPG20-1519HCL	Recombinant Human SPG20 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	Spg20-6090M	Recombinant Mouse Spg20 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SPG20 Related Articles

SPG20 involved in several pathways and played different roles in them. We selected most pathways SPG20 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPG20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Endocytosis	KIF5B;BIN1B;GIT2;FAM125B;SNX3;ASAP1;SH3GLB1;DNM2A;GRK1

SPG20 has several biochemical functions, for example, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPG20 itself. We selected most functions SPG20 had, and list some proteins which have the same functions with SPG20. You can find most of the proteins on our site.

Function	Related Protein
protein binding	PRDM16;TTK;PTPN18;METAP2;CCDC9;ACYP2;RARS;NR2F6;C1orf116
ubiquitin protein ligase binding	HSPD1;HSPA9;TANK;DIO2;PRKAR2B;LRPPRC;PIAS4;RFFL;CUL3

SPG20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPG20 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPG20.

HSPA5; NCL; HSPA9; Map3k1; HTT; SMAD2; ZFYVE9; papC; cpxR; SMURF2; APPL1; SEC16A; ACSL4; ACSL3; AIFM1; VIM; UBB

Robay, D; Patel, H; et al. Endogenous spartin, mutated in hereditary spastic paraplegia, has a complex subcellular localization suggesting diverse roles in neurons. EXPERIMENTAL CELL RESEARCH 312:2764-2777(2006).

Lu, J; Rashid, F; et al. The hereditary spastic paraplegia protein spartin localises to mitochondria. JOURNAL OF NEUROCHEMISTRY 98:1908-1919(2006).

Bakowska, JC; Jenkins, R; et al. The Troyer syndrome (SPG20) protein spartin interacts with Eps15. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 334:1042-1048(2005).