sphk1
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  • Official Full Name
  • sphingosine kinase 1
  • Background
  • The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
  • Synonyms
  • SPHK1; sphingosine kinase 1; SPHK; SK 1; SPK 1;
Cat.#:SPHK1-2567HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SPHK1 Protein, MYC/DDK-tagged
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Cat.#:SPHK1-1299HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SPHK1 protein, His-tagged
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Cat.#:SPHK1-174HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human SPHK1 protein, GST-tagged, Active
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Cat.#:SPHK1-263HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SPHK1, Gly & Pro tagged
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Cat.#:SPHK1-277HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SPHK1, His-GST tagged
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Cat.#:SPHK1-2915HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SPHK1, GST-tagged
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Cat.#:SPHK1-523HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Sphingosine Kinase 1, His-tagged
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Cat.#:SPHK1-656HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human SPHK1
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Cat.#:SPHK1-741HTag:Met/His
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Human
Product nameRecombinant Human SPHK1 Protein, Met & His-tagged
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Cat.#:SPHK1-77HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human SPHK1 protein, Flag-tagged, Biotinylated
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Cat.#:SPHK1-15877MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SPHK1 Protein
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Cat.#:Sphk1-524MTag:His
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Sphingosine Kinase 1, His-tagged
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Cat.#:Sphk1-526MTag:Met/His
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Sphk1 protein, Met/His-tagged
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Cat.#:SPHK1-5705RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SPHK1 Protein
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Cat.#:SPHK1-1483HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human SPHK1 (Active), GST-tagged
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Cat.#:SPHK1-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SPHK1 cell lysate
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Involved Pathway

SPHK1 involved in several pathways and played different roles in them. We selected most pathways SPHK1 participated on our site, such as Sphingolipid metabolism, Metabolic pathways, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPHK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Sphingolipid metabolism
NEU3.5; ARSE; SPTLC1; SPHK2; SGPP2; ARSA; COL4A3BP; UGT8A; PPM1LA; PPAP2CB
Metabolic pathways
HSD3B6; GBGT1; UAP1L1; ENO1A; NOS1; NME7; PIP5K1A; ITPK1A; CEPT1B; FTCD
Calcium signaling pathway
PPP3CA; PHKA1; LTB4R2; DRD1A; HTR2CL1; GRIN1B; ADRa1A; CHRM5; ATP2A2B; GNA11
Sphingolipid signaling pathway
PPP2R3A; ROCK2; MAPK10; PLD2; RAC1; PRKCB; AKT1; PIK3CG; BAX; SPTLC1
Phospholipase D signaling pathway
PIP5K1B; CYTH3; GAB1; MTOR; AVPR1B; SHC1; PIP5K1A; PIK3R2; Kitl; ARF6
VEGF signaling pathway
VEGFAB; PLCG2; NOS3; PTK2AA; PXNA; RAF1B; SRC; PPP3R1; PIK3R3B; PIK3CA
Fc gamma R-mediated phagocytosis
LIMK2; PRKCE; PTPRC; RAC1; ARPC5L; PIK3CB; PIK3R2; INPP5D; CFL2; VAV3
Tuberculosis
CLEC4E; IL1A; CD14; ITGB2L; IRAK1; CD209; IRAK2; IFNA4; FCGR3; IFNA10

Protein Function

SPHK1 has several biochemical functions, for example, ATP binding, D-erythro-sphingosine kinase activity, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPHK1 itself. We selected most functions SPHK1 had, and list some proteins which have the same functions with SPHK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ADRBK2; RIMKLA; RAD51B; DNAH5; BMPR2A; PSMC5; EIF4A1; CAMK1DA; UBE2M; SMARCA2
Function D-erythro-sphingosine kinase activity
Related Protein SPHK2; SPHK1
Function DNA binding
Related Protein HIST1H111L; NPAS2; TSHZ3; ARID5B; MB21D1; ZNF385A; POLR1E; CCDC79; ASCL1B; HER2
Function calmodulin binding
Related Protein MYH7; MYO5C; MARCKSL1B; USP6; MYO1D; ITPKB; SPTBN1; INVS; MKNK1; RGS4
Function magnesium ion binding
Related Protein PPM1BA; CLYBL; PRPS1B; DCTPP1; PPM1AB; ATP11C; PI4K2A; PGM5; RPS6KA6; NT5C1B
Function protein binding
Related Protein CDC45; ATXN3; G6PD; LPL; UHMK1; NCOA5; STAC; MPZL2; FGFR1B; AGBL4
Function protein phosphatase 2A binding
Related Protein SHC1; ANKLE2; TP53; PPP2R2A; GRIN3A; IGBP1; PPP2R4; SMG7; ARPP19; ENSA
Function sphinganine kinase activity
Related Protein SPHK1; SPHK2
Function sphingosine-1-phosphate receptor activity
Related Protein GPR6; S1PR1; S1PR5A; S1PR5; S1PR3; SPHK1; SPHK2; S1PR4; S1PR5B; S1PR2

Interacting Protein

SPHK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPHK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPHK1.
SPHKAP; EEF1A1; FHL2; FYN; CTSB; TRAF6

SPHK1 Related Articles

Eberlein, C; Rooney, C; et al. E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin alpha v beta 6 and maintained through TGF beta signalling. ONCOGENE 34:704-716(2015).
Camare, C; Trayssac, M; et al. Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. BRITISH JOURNAL OF PHARMACOLOGY 172:106-118(2015).