spon1
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  • Official Full Name
  • spondin 1, extracellular matrix protein
  • Background
  • SPON1 is a member of a subgroup of the thrombospondin type 1 (TSR) class molecules, defined by two domains of homology, the FS1/FS2 and TSR domains. The TSRs of SPON1 proteins are typical of class 2 TSRs. SPON1, which is similar to thrombospondin, is a extracellular matrix attached molecule that promotes neurite outgrowth and inhibits angiogenesis. Analysis of gain and loss of function experiments reveal that SPON1 is required for accurate pathfinding of embryonic axons, and plays a dual role in patterning axonal trajectories. It promotes the outgrowth of commissural and inhibits the outgrowth of motor axons, and has also been implicated in inflammatory processes in the nervous system.
  • Synonyms
  • SPON1; spondin 1, extracellular matrix protein; f-spondin; VSGP/F-spondin; spondin-1; spondin 1, (f-spondin) extracellular matrix protein; vascular smooth muscle cell growth-promoting factor
Cat.#:SPON1-215HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SPON1 Protein, His-tagged
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Cat.#:Spon1-216MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Spon1 Protein, His-tagged
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Cat.#:SPON1-408HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human Spondin 1, Extracellular Matrix Protein, His-tagged
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Cat.#:SPON1-734HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human SPON1
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Cat.#:SPON1-15918MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SPON1 Protein
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Cat.#:SPON1-5717RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SPON1 Protein
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Cat.#:SPON1-4441RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SPON1 Protein, His-tagged
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Cat.#:SPON1-6414CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SPON1
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Cat.#:SPON1-1504HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SPON1 293 Cell Lysate
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Involved Pathway

SPON1 involved in several pathways and played different roles in them. We selected most pathways SPON1 participated on our site, such as Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPON1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolism of proteins
MIA3; SAMM50; VBP1; DOHH; ADAMTS8; IGFBP2B; TIMM10; CPA3; GALNT6; ALG2
O-glycosylation of TSR domain-containing proteins
THSD1; ADAMTS10; C8orf84; ADAMTSL4; B3GALTL; SPON2; ADAMTS13; ADAMTS18; ADAMTSL5; THSD7A
O-linked glycosylation
ADAMTS20; THSD1; ADAMTS8; ADAMTS15; ADAMTS1; ADAMTSL1; B3GNT8; SPON1A; ADAMTS3; GALNTL5
Post-translational protein modification
DHPS; MUC15; SPON2; MGAT4A; SPON1; PIGK; ALG10B; BET1; PPP6C; MAN1B1

Protein Function

SPON1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPON1 itself. We selected most functions SPON1 had, and list some proteins which have the same functions with SPON1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein HSPH1; EML2; ZBTB26; FKBP8; ZNF177; LRRC4C; HSPA8; MALT1; PEX2; MAP4K3

Interacting Protein

SPON1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPON1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPON1.
APP; APLP1; APLP2; q9wmx2-pro_0000037548