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SPP1

  • Official Full Name

    secreted phosphoprotein 1

  • Overview

    The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • Synonyms

    SPP1; secreted phosphoprotein 1; OPN; BNSP; BSPI; ETA-1; osteopontin; uropontin; nephropontin; SPP1/CALPHA1 fusion; urinary stone protein; early T-lymphocyte activation 1; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Dog
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • Sf9 Insect Cell
  • Yeast
  • C
  • His
  • DDK
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • MBP
  • Myc
  • Myc|DDK
  • N/A
  • N
  • SUMO
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SPP1-120H Active Recombinant Human Secreted Phosphoprotein 1, HIgG1 Fc-tagged, mutant CHO Fc
Human SPP1-5130H Active Recombinant Human Secreted Phosphoprotein 1 Human N/A
Human SPP1-705H Active Recombinant Human SPP1 Protein HEK293 N/A
Human SPP1-616H Active Recombinant Human SPP1, His-tagged Mammalian cells His
Human SPP1-121H Active Recombinant Human Secreted Phosphoprotein 1, MIgG2a Fc-tagged CHO Fc
Human SPP1-122H Active Recombinant Human Secreted Phosphoprotein 1, HIgG1 Fc-tagged CHO Fc
Human SPP1-447H Recombinant Human SPP1 protein, His-tagged HEK293F His Ile17~Asn287
Human SPP1-260H Recombinant Human SPP1, StrepII-tagged Human Cell Strep II 17-314, 298 a.a.
Human SPP1-28248TH Recombinant Human SPP1, MBP-tagged E.coli MBP
Human SPP1-314H Recombinant Human SPP1 protein, His-tagged HEK293 His Ile17-Gly166
Human SPP1-5129H Recombinant Human Secreted Phosphoprotein 1, His-tagged Human His
Human SPP1-570H Recombinant Human SPP1 protein, His-tagged E.coli His Ile17~Asn287
Human SPP1-815H Recombinant Human Secreted Phosphoprotein 1, GST-tagged E.coli GST
Human SPP1-706H Recombinant Human SPP1 Protein, DDK-tagged Sf9 Insect Cell DDK
Human SPP1-664H Recombinant Human SPP1, His tagged HEK293 His Met 1-Asn 314
Human SPP1-5246H Recombinant Human SPP1 Protein, GST-tagged E.coli GST
Human SPP1-372H Recombinant Human Secreted Phosphoprotein 1, His-tagged E.coli His
Human SPP1-816H Recombinant Human Secreted Phosphoprotein 1, MBP-tagged E.coli MBP
Human SPP1-30522TH Recombinant Human SPP1 N/A
Human SPP1-2535HCL Recombinant Human SPP1 cell lysate Human Cell N/A
Human SPP1-91HFL Active Recombinant Full Length Human SPP1 Protein, C-Flag-tagged Mammalian cells Flag
Human SPP1-4058H Recombinant Human SPP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CAB11606RH Rabbit Monoclonal Antibody to Human Secreted Phosphoprotein 1 Rabbit N/A
Human SPP1-2680H Recombinant Human SPP1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SPP1-001H Recombinant Human SPP1 Protein, MBP-tagged E.coli MBP 1-300
Human SPP1-5435H Recombinant Human SPP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SPP1-040H Active Recombinant Human SPP1 Protein, His-tagged E. coli His
Human SPP1-336H Recombinant Human SPP1 protein, His-tagged HEK293 His 284
Human SPP1-002H Recombinant Human SPP1 Protein, GST-tagged E.coli GST 59-300
Human SPP1-1249H Recombinant Human SPP1 protein, His-tagged Yeast His 17-300aa
Human SPP1-3044H Recombinant Human SPP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SPP1-0597H Active Recombinant Human SPP1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ile17-Asn300
Human SPP1-004H Active Recombinant Human SPP1 Protein, His-tagged E.coli His 17-314aa
Human SPP1-4137H Recombinant Human SPP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SPP1-828H Recombinant Human SPP1 Protein HEK293 314
Human SPP1-5118H Recombinant Human SPP1 Protein (Ile17-Asn314), N-His tagged E.coli N-His Ile17-Asn314
Human SPP1-4137H-B Recombinant Human SPP1 Protein Pre-coupled Magnetic Beads HEK293
Human SPP1-6348H Recombinant Human SPP1 Protein (Ile17-Asn314), C-His tagged Mammalian cells C-His Ile17-Asn314
Mouse Spp1-1772M Recombinant Mouse Secreted Phosphoprotein 1 Mammalian cells N/A
Mouse SPP1-465M Recombinant Mouse SPP1 protein, His-tagged HEK293F His Leu17~Asn294
Mouse SPP1-0598M Recombinant Mouse SPP1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Leu17-Asn294
Mouse Spp1-2095M Recombinant Mouse Spp1 Protein, His-tagged E.coli N-His Val138-Asn294
Mouse Spp1-01M Active Recombinant Mouse Spp1 Protein, His-tagged HEK293 His 17-294aa
Mouse Spp1-6106M Recombinant Mouse Spp1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Spp1-10615M Recombinant Mouse Spp1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Spp1-10615M-B Recombinant Mouse Spp1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Spp1-2096M Recombinant Mouse Spp1 Protein, His&GST-tagged E.coli N-His&GST Leu17-Asn294
Mouse Spp1-5525M Recombinant Mouse Spp1 protein, His-tagged Yeast His 17-290aa
Rat Spp1-571R Recombinant Rat Spp1 protein, His-tagged HEK293F His Leu17~Asn317
Rat SPP1-5719R Recombinant Rat SPP1 Protein Mammalian Cell His
Rat SPP1-5378R Recombinant Rat SPP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SPP1-5378R-B Recombinant Rat SPP1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey SPP1-7902R Recombinant Rhesus monkey SPP1 protein, His-tagged E.coli His Pro18~Asn314 (Accession # F6V2X3)
Rabbit SPP1-1166R Recombinant Rabbit SPP1 Protein, His-tagged E.coli N-His Leu17-Asn314
Dog SPP1-7901D Recombinant Dog SPP1 protein, His-tagged E.coli His Ile7~Ser232
Dog SPP1-1167D Recombinant Dog SPP1 Protein, His&SUMO-tagged E.coli N-His&SUMO Met1-Asn272
Cattle SPP1-1165C Recombinant Cattle SPP1 Protein, His&GST-tagged E.coli N-His&GST Leu17-Asn278
Rhesus Macaque SPP1-4444R Recombinant Rhesus monkey SPP1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SPP1-4260R-B Recombinant Rhesus Macaque SPP1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SPP1-4260R Recombinant Rhesus Macaque SPP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish SPP1-457Z Recombinant Zebrafish SPP1 Mammalian Cell His
Pig SPP1-1164P Recombinant Pig SPP1 Protein, His-tagged E.coli N-His Thr37-Asn303
Chicken SPP1-6104C Recombinant Chicken SPP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SPP1 Related Articles

SPP1 involved in several pathways and played different roles in them. We selected most pathways SPP1 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PIK-Akt signaling pathwayFGF5;RAC1;PIK3R1;NFKB1;RAF1;FGF11;EPOR;IFNA10;MAPK3
Focal adhesionSPP1;PDPK1B;ITGA2B;ITGA3;GRB2A;PARVAA;TNXB;MAPK8;VEGFAB
ECM-receptor interactionCOL27A1B;ITGA6B;VTNA;TNR;COL6A2;LAMA3;ITGA11A;FN1;THBS4
Toll-like receptor signaling pathwayCCL3L3;MAP2K2B;IL1B;IFNA5;IFNA7;RIPK1;MAP2K4;IFNA8;TOLLIP

SPP1 has several biochemical functions, for example, cytokine activity, extracellular matrix binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPP1 itself. We selected most functions SPP1 had, and list some proteins which have the same functions with SPP1. You can find most of the proteins on our site.

Function Related Protein
cytokine activityIL25;NODAL;SECTM1;FAM3D;TNFSF10;IL18;IL24;GDF10B;IFNA16
extracellular matrix bindingSPP1;ITGA2B;GPR56;VEGFA;BGN;SPARC;FBLN2;ITGAV;DCN
protein bindingTHAP11;MRPS27;SNCA;FASTK;RGS20;C22orf13;ADRA2A;TUBA1C;COPS7B

SPP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPP1.

SGTA; CD44; MEOX2; UBQLN4; F2; APOA1; PEPD; BAG6; CTNNBL1; PDLIM7

Shi, M; Movius, J; et al. Cerebrospinal Fluid Peptides as Potential Parkinson Disease Biomarkers: A Staged Pipeline for Discovery and Validation. MOLECULAR & CELLULAR PROTEOMICS 14:544-555(2015).
Gazal, S; Sacre, K; et al. Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene. ANNALS OF THE RHEUMATIC DISEASES 74:-(2015).
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