spr
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  • Official Full Name
  • sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
  • Background
  • This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1.
  • Synonyms
  • SPR; sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase); sepiapterin reductase; SDR38C1; short chain dehydrogenase/reductase family 38C; member 1; OTTHUMP00000160199; short chain dehydrogenase/reductase family 38C, member 1; SPRE_HUMAN
Cat.#:SPR-681HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SPR Protein, His/GST-tagged
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Cat.#:Spr-205MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Spr Protein, His-tagged
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Cat.#:Spr-682MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Spr Protein, His-tagged
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Cat.#:SPR-2931HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SPR, GST-tagged
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Cat.#:SPR-30400THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SPR, His-tagged
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Cat.#:SPR-30401THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SPR, His-tagged
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Cat.#:SPR-4446RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SPR Protein, His-tagged
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Cat.#:SPR-190HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Sepiapterin Reductase, His-tagged
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Cat.#:SPR-1499HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SPR 293 Cell Lysate
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Involved Pathway

SPR involved in several pathways and played different roles in them. We selected most pathways SPR participated on our site, such as Folate biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Folate biosynthesis
GGH; QDPRB1; QDPRA; MOCS1; DHFR; ALPL; ALPI; GCH2; MOCS2; SPR
Metabolic pathways
CYP2J5; RDH8B; GALNT10; GALNT18A; AK7B; GALNT7; GMPS; PKM; Aldh1a7; COQ6

Protein Function

SPR has several biochemical functions, for example, NADP binding, aldo-keto reductase (NADP) activity, sepiapterin reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPR itself. We selected most functions SPR had, and list some proteins which have the same functions with SPR. You can find most of the proteins on our site.
Function
Related Protein
Function NADP binding
Related Protein CRYM; IDH1; DHFRL1; G6PDX; DPYD; SPR; H6PD; POR; G6PD; NOS1
Function aldo-keto reductase (NADP) activity
Related Protein KCNAB1; H2-KE6; SDR42E1; AKR1B1; CYB5A; HSD3B6; HSD11B1LA; MIOX; HSD3B5; SDR16C6
Function sepiapterin reductase activity
Related Protein SPR; SPRA; SPRB

Interacting Protein

SPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPR here. Most of them are supplied by our site. Hope this information will be useful for your research of SPR.
YWHAZ; midostaurin

SPR Related Articles

Suherman; Morita, K; et al. Highly selective and sensitive detection of beta-agonists using a surface plasmon resonance sensor based on an alkanethiol monolayer functionalized on a Au surface. BIOSENSORS & BIOELECTRONICS 67:356-363(2015).
Soler, M; Mesa-Antunez, P; et al. Highly sensitive dendrimer-based nanoplasmonic biosensor for drug allergy diagnosis. BIOSENSORS & BIOELECTRONICS 66:115-123(2015).