SPRED1
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Official Full Name
sprouty-related, EVH1 domain containing 1
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Overview
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). -
Synonyms
SPRED1; sprouty-related, EVH1 domain containing 1; sprouty-related, EVH1 domain-containing protein 1; FLJ33903; hSpred1; spred-1; suppressor of Ras/MAPK activation; EVH1/Sprouty domain containing protein; NFLS;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- SUMO
- Myc
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- SPRED1 Related Articles
- SPRED1 Related Research Area
SPRED1 involved in several pathways and played different roles in them. We selected most pathways SPRED1 participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPRED1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ARMS-mediated activation | PSMD14;DLG4;CSF2RA;FGF8B;AKAP9;KIDINS220B;PSMD10;NTF7;JAK3 |
Axon guidance | SEMA3AA;Plxna2;GDNF;GSK3B;EPHA10;EFNA1;SPTB;ACTR2B;GNAI1 |
Cytokine Signaling in Immune system | TRIM29;PEA15;MARK3;IFIT8;CSF2;JAK3;HBEGF;KLB;CSF2RA |
DAP12 interactions | SPRED1;FGF20A;WDR83;AGO2;SPNA1;SPTA1;AGO3;JAK1;SPTBN2 |
DAP12 signaling | PEA15;MARK3;NEFLB;DUSP1;PTPRA;SPTBN2;FGF20A;CSF2RA;FRS2 |
Developmental Biology | PAK4;CEBPA;FGF20A;CD24;DUSP10;AP2A2;ITGB3A;GPC1B;TCF3B |
Downstream signal transduction | SPTA1;CNKSR1;RASGRP4;LAMTOR2;SPNA1;PTPRA;SPRED1;SPTBN1;KBTBD7 |
Downstream signaling of activated FGFR1 | PTPRA;RASGRP4;CNKSR1;SPNA1;SPRED2;RASGEF1A;PAQR3A;WDR83;PHB |
SPRED1 has several biochemical functions, for example, phosphatase binding, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPRED1 itself. We selected most functions SPRED1 had, and list some proteins which have the same functions with SPRED1. You can find most of the proteins on our site.
Function | Related Protein |
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phosphatase binding | MAST2;PPARA;SH3YL1;KLRAQ1;CTSC;TRPC4AP;SMAD2;SLC9A3R2;CRY2 |
protein binding | ADAMTSL5;RNF34;SYNJ2BP;ANXA4;TCTN2;MECP2;UPRT;GAD2;TRAFD1 |
protein kinase binding | CEP152;CACNB3;CNPPD1;PLCG1;KIF11;TPX2;DVL1;MAML1;PTPRJ |
protein serine/threonine kinase inhibitor activity | H2AFY;SPRY2;CIB1;SPRED1;SPRED2 |
stem cell factor receptor binding | SPRED2;Kitl;KITLGB;KITLGA;KITLG;SPRED1 |
SPRED1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPRED1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPRED1.
PPP1CA; ZDHHC17; SUV39H1; RCC1; CDKN1A; PPP1R7; TSC22D1; TTC19; FAM118B; OSGEP; DNAJB11; NAGK
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