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SPRED1

  • Official Full Name

    sprouty-related, EVH1 domain containing 1

  • Overview

    The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).
  • Synonyms

    SPRED1; sprouty-related, EVH1 domain containing 1; sprouty-related, EVH1 domain-containing protein 1; FLJ33903; hSpred1; spred-1; suppressor of Ras/MAPK activation; EVH1/Sprouty domain containing protein; NFLS;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SPRED1-630H Recombinant Human sprouty-related, EVH1 domain containing 1, His-tagged E.coli His
Human SPRED1-1498HCL Recombinant Human SPRED1 293 Cell Lysate HEK293 N/A
Human SPRED1-4593H Recombinant Human SPRED1 protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc 2-444aa
Mouse SPRED1-15925M Recombinant Mouse SPRED1 Protein Mammalian Cell His
Mouse SPRED1-8674M-B Recombinant Mouse SPRED1 Protein Pre-coupled Magnetic Beads HEK293
Mouse SPRED1-8674M Recombinant Mouse SPRED1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SPRED1-4447R Recombinant Rhesus monkey SPRED1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SPRED1-4263R Recombinant Rhesus Macaque SPRED1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SPRED1-4263R-B Recombinant Rhesus Macaque SPRED1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SPRED1-12434Z Recombinant Zebrafish SPRED1 Mammalian Cell His
Chicken SPRED1-4465C Recombinant Chicken SPRED1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SPRED1 Related Articles
  • SPRED1 Related Research Area

SPRED1 involved in several pathways and played different roles in them. We selected most pathways SPRED1 participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPRED1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationPSMD14;DLG4;CSF2RA;FGF8B;AKAP9;KIDINS220B;PSMD10;NTF7;JAK3
Axon guidanceSEMA3AA;Plxna2;GDNF;GSK3B;EPHA10;EFNA1;SPTB;ACTR2B;GNAI1
Cytokine Signaling in Immune systemTRIM29;PEA15;MARK3;IFIT8;CSF2;JAK3;HBEGF;KLB;CSF2RA
DAP12 interactionsSPRED1;FGF20A;WDR83;AGO2;SPNA1;SPTA1;AGO3;JAK1;SPTBN2
DAP12 signalingPEA15;MARK3;NEFLB;DUSP1;PTPRA;SPTBN2;FGF20A;CSF2RA;FRS2
Developmental BiologyPAK4;CEBPA;FGF20A;CD24;DUSP10;AP2A2;ITGB3A;GPC1B;TCF3B
Downstream signal transductionSPTA1;CNKSR1;RASGRP4;LAMTOR2;SPNA1;PTPRA;SPRED1;SPTBN1;KBTBD7
Downstream signaling of activated FGFR1PTPRA;RASGRP4;CNKSR1;SPNA1;SPRED2;RASGEF1A;PAQR3A;WDR83;PHB

SPRED1 has several biochemical functions, for example, phosphatase binding, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPRED1 itself. We selected most functions SPRED1 had, and list some proteins which have the same functions with SPRED1. You can find most of the proteins on our site.

Function Related Protein
phosphatase bindingMAST2;PPARA;SH3YL1;KLRAQ1;CTSC;TRPC4AP;SMAD2;SLC9A3R2;CRY2
protein bindingADAMTSL5;RNF34;SYNJ2BP;ANXA4;TCTN2;MECP2;UPRT;GAD2;TRAFD1
protein kinase bindingCEP152;CACNB3;CNPPD1;PLCG1;KIF11;TPX2;DVL1;MAML1;PTPRJ
protein serine/threonine kinase inhibitor activityH2AFY;SPRY2;CIB1;SPRED1;SPRED2
stem cell factor receptor bindingSPRED2;Kitl;KITLGB;KITLGA;KITLG;SPRED1

SPRED1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPRED1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPRED1.

PPP1CA; ZDHHC17; SUV39H1; RCC1; CDKN1A; PPP1R7; TSC22D1; TTC19; FAM118B; OSGEP; DNAJB11; NAGK

Skelton, TS; Tejpal, N; et al. Allochimeric molecules and mechanisms in abrogation of cardiac allograft rejection. JOURNAL OF HEART AND LUNG TRANSPLANTATION 31:73-84(2012).
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