Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

SPRY2

Official Full Name

sprouty homolog 2 (Drosophila)
Overview

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]
Synonyms

SPRY2; sprouty homolog 2 (Drosophila); hSPRY2; protein sprouty homolog 2; spry-2; sprouty 2;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
His|T7
Myc
DDK
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SPRY2-1490HCL	Recombinant Human SPRY2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SPRY2-1714HFL	Recombinant Full Length Human SPRY2 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	SPRY2-3538H	Recombinant Human SPRY2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	SPRY2-1797H	Recombinant Human SPRY2 protein, His & T7-tagged	E.coli	His/T7	Ser116~Thr305 (Accession # O43597)	Inquiry
Human	SPRY2-2091H	Recombinant Human SPRY2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	SPRY2-2091H-B	Recombinant Human SPRY2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	SPRY2-5523H	Recombinant Human SPRY2 Protein (Ser116-Thr305), N-His tagged	E.coli	N-His	Ser116-Thr305	Inquiry
Mouse	Spry2-1798M	Recombinant Mouse Spry2 protein, His & T7-tagged	E.coli	His/T7	Gly116~Thr305 (Accession # Q9QXV8)	Inquiry
Mouse	Spry2-6110M	Recombinant Mouse Spry2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	Spry2-1799R	Recombinant Rat Spry2 protein, His & T7-tagged	E.coli	His/T7	Gly116~Thr304 (Accession # Q5HZA2)	Inquiry
Zebrafish	SPRY2-1131Z	Recombinant Zebrafish SPRY2	Mammalian Cell	His		Inquiry
Chicken	SPRY2-6363C	Recombinant Chicken SPRY2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SPRY2 Related Articles
SPRY2 Related Research Area

SPRY2 involved in several pathways and played different roles in them. We selected most pathways SPRY2 participated on our site, such as EGFR downregulation, EGFR1 Signaling Pathway, FGF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPRY2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
EGFR downregulation	STAM2;AP2M1;AP2S1;AP2A2;AP2B1;SPRY1;AP2A1;PTPRK;SPRY2
EGFR1 Signaling Pathway	RALBB;RALBA;SH3BGRL;CRKL;ARF4;ABI1B;MTA2;EEF1A1;PITPNA
FGF signaling pathway	FGFRL1A;TA;SOX32;EGR2A;SP8A;SP8B;EGR2B;PAK4;JUNBA
Internalization of ErbB1	SPRY2;STAMBP;FMNL3;RNF103-CHMP3;ZFYVE28
MicroRNAs in cancer	DNMT1;STAT3;CCND2;BCL2;RPS6KA5;SHC1;MDM4;GLS;TGFB2
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling

SPRY2 has several biochemical functions, for example, protein binding, protein kinase binding, protein serine/threonine kinase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPRY2 itself. We selected most functions SPRY2 had, and list some proteins which have the same functions with SPRY2. You can find most of the proteins on our site.

Function	Related Protein
protein binding	NOD1;TBXA2R;PTGER4;HOMER3;PSMB3;PPP3CA;C11orf67;MBNL3;CD200R3
protein kinase binding	PTPRK;SPDYA;MAPK4;CCND1;CCNA2;BORA;GYS1;CCNB1;H2AFY
protein serine/threonine kinase activator activity	STK4;STRADA;MAP2K1;CALM3;IGF2;CALM2;STK3;LTF;ALS2
protein serine/threonine kinase inhibitor activity	SPRED1;SPRY2;CIB1;SPRED2;H2AFY

SPRY2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPRY2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPRY2.

CBL; OTX1

Peralvarez-Marin, A; Tae, H; et al. 3D Mapping of the SPRY2 Domain of Ryanodine Receptor 1 by Single-Particle Cryo-EM. PLOS ONE 6:-(2011).

Tae, H; Wei, L; et al. The elusive role of the SPRY2 domain in RyR1. CHANNELS 5:148-160(2011).

FGF Family

Phospholipases, Small GTPases, and Other Molecules in the Akt Pathway