spsb2
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  • Official Full Name
  • splA/ryanodine receptor domain and SOCS box containing 2
  • Background
  • This gene encodes encodes a suppressor of cytokine signaling (SOCS) family member, and it belongs to the subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal SOCS box. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • SPSB2; splA/ryanodine receptor domain and SOCS box containing 2; SPRY domain-containing SOCS box protein 2; GRCC9; SSB 2; gene-rich cluster protein C9; SPRY domain-containing SOCS box protein SSB-2; SSB2; MGC2519; FLJ17395
Cat.#:SPSB2-5319HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human SPSB2 Protein, GST-tagged
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Cat.#:SPSB2-2942HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SPSB2, His-tagged
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Cat.#:SPSB2-7212HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SplA/ryanodine Receptor Domain And SOCS Box Containing 2, His-tagged
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Cat.#:SPSB2-15951MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SPSB2 Protein
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Cat.#:SPSB2-5726RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SPSB2 Protein
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Cat.#:SPSB2-1486HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SPSB2 293 Cell Lysate
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Involved Pathway

SPSB2 involved in several pathways and played different roles in them. We selected most pathways SPSB2 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPSB2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
ITK; CSK; KLC3; SPSB1; RAPGEF4; UBE2U; MGC174152; AF251705; RBCK1; UBE2F
Antigen processing: Ubiquitination &
DTX3L; ASB8; UBE2J2; RNF25; ASB10; ATG7; ASB9; LRR1; SH3RF1; ASB11
Proteasome degradation
RNF4; UBE2V1; PJA1; LRR1; LRSAM1; RNF19B; RNF144B; ASB11; TRIM41; UBR2
Class I MHC mediated antigen processing &
UBE2F; TRIM69; RNF4; HUWE1; CYBA; KLHL20; ASB3; UBE2E3; RNF182; ASB18
presentation
UBA5; ASB3; SPSB1; WWP1; TRIM9; RBCK1; RNF144B; BLMH; CYBA; B2ML
Immune System
SIGLEC10; IFIT12; ABI2; RIPK3; SIGLEC15; NCKIPSD; RNF19B; DCTN6; SEC61B; SAMHD1

Protein Function

SPSB2 has several biochemical functions, for example, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPSB2 itself. We selected most functions SPSB2 had, and list some proteins which have the same functions with SPSB2. You can find most of the proteins on our site.
Function
Related Protein
Function molecular_function
Related Protein GM3750; NANOS1; SPRED2B; PPP4R1L; ADAMTS16; CMIP; GSDMC; SHF; MFSD4B; TMEM188
Function protein binding
Related Protein GRN; ZCCHC7; PTPN12; MEP1A; SLC22A3; GAB3; TEF; AGTRAP; SMO; CRHR2

Interacting Protein

SPSB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPSB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPSB2.
PIK3R3; vas; TCEB1; PRMT1; PAWR; GALNT15; TCEB2; CUL5; RNF7

SPSB2 Related Articles

Leung, EWW; Yagi, H; et al. F-19 NMR as a Probe of Ligand Interactions with the iNOS Binding site of SPRY Domain-Containing SOCS Box Protein 2. CHEMICAL BIOLOGY & DRUG DESIGN 84:616-625(2014).
Yap, BK; Leung, EWW; et al. A Potent Cyclic Peptide Targeting SPSB2 Protein as a Potential Anti-infective Agent. JOURNAL OF MEDICINAL CHEMISTRY 57:7006-7015(2014).