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SPTA1

Official Full Name

spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
Overview

Spectrin is a major constituent of the erythrocyte skeleton accounting for 25% of the total membrane protein and 75% of the cytoskeletal mass. Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton by associating with the cytoplasmic surface of the membrane by attachment to ankyrin. The membrane skeleton influences several cellular properties such as cell shape, restriction of mobility of the integral membrane protein exposed at the cell surface and transmembrane movement of phospholipids and cholesterol and organization of organelles. Spectrin is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. Mutations in spectrin result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.
Synonyms

SPTA1; spectrin, alpha, erythrocytic 1 (elliptocytosis 2); spectrin alpha chain, erythrocyte; EL2; alpha-I spectrin; erythroid alpha-spectrin; HPP; HS3; SPH3; SPTA;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SPTA1-1389H	Recombinant Human SPTA1, GST-tagged	E.coli	GST		Inquiry
Human	SPTA1-4572H	Recombinant Human SPTA1 protein, His-tagged	Mammalian cell	His	53-474aa	Inquiry
Human	SPTA1-4571H	Recombinant Human SPTA1 protein, His-tagged	Insect Cell	His	53-474aa	Inquiry
Human	SPTA1-114H	Recombinant Human SPTA1 Protein, GST-tagged	E.coli	GST		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SPTA1 Related Articles

SPTA1 involved in several pathways and played different roles in them. We selected most pathways SPTA1 participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ARMS-mediated activation	JAK3;DAB2IPB;PSMA8;PAQR3B;RASGEF1A;KIDINS220B;NRG4;JAK1;FRS3
Axon guidance	RASA1;KIF4;CXCL12;UNC5A;NRAS;EPHA8;EFNB3B;COL4A3;RGMA
Cytokine Signaling in Immune system	IRAK3;GBP4;FRS3;JAK3;TRIM3;PAQR3B;IFIT3;FGF20A;OASL
DAP12 interactions	DUSP4;PEA15;DUSP9;AGO3;SPRED2;JAK3;SPRED3;KIR3DS1;DUSP5
DAP12 signaling	DUSP9;CNKSR1;MOV10;IL17RD;FGF8B;PEBP1;DUSP6;WDR83;DUSP5
Developmental Biology	CAP2;NRP2;RHOC;LGI2;MED23;DPYSL2B;MEF2AA;DCX;MED8
Downstream signal transduction	KBTBD7;DUSP7;FGF20A;SPTB;IL17RD;PAQR3B;PHB;SPRED2;CRKL
Downstream signaling of activated FGFR1	PEA15A;DUSP9;AGO2;WDR83;PEA15;IL17RD;SPTA1;PAQR3A;DAB2IPB

SPTA1 has several biochemical functions, for example, actin filament binding, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTA1 itself. We selected most functions SPTA1 had, and list some proteins which have the same functions with SPTA1. You can find most of the proteins on our site.

Function	Related Protein
actin filament binding	DBNL;MYH9A;MYO3A;MYH11;SLC6A4;TMOD1;ADD2;MTSS1;FSCN3
calcium ion binding	PCDHGA2;PLS3;MMP13;CDH2;PVALB5;CASQ1B;PCDH1G3;CABP1;PCDHGC4
protein binding	PAX6;SHC3;SIN3A;MED26;STXBP3;SRP14;SRSF3;SMCO3;BRK1
protein heterodimerization activity	POLE4;UGT1A3;SOX32;ARNT;HIST1H3G;RBP4;CHRNA3;EXT2;STX1A
structural constituent of cytoskeleton	SPTBN1;TNNT2A;TUBGCP5;TUBG1;TUBB2B;HIP1;F-KER;TUBB6;TUBA8L3

SPTA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTA1.

SPTB; SPTBN1; ABI1; FASLG; Evl; VASP; ENAH; EVL; CBL; SHC1; BTK; UBASH3B

Bogardus, H; Schulz, VP; et al. Severe nondominant hereditary spherocytosis due to uniparental isodisomy at the SPTA1 locus. HAEMATOLOGICA 99:E168-E170(2014).

Connor, J; Dagaonkar, N; et al. AUTOSOMAL RECESSIVE HEREDITARY SPHEROCYTOSIS IN PATIENTS WITH THE C.4339-99C> T alpha LEPRA MUTATION IN THE SPTA1 GENE. PEDIATRIC BLOOD & CANCER 61:S16-S17(2014).