sptlc1
Share
  • Official Full Name
  • serine palmitoyltransferase, long chain base subunit 1
  • Background
  • Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.
  • Synonyms
  • SPTLC1; serine palmitoyltransferase, long chain base subunit 1; hereditary sensory neuropathy, type 1 , HSN1; serine palmitoyltransferase 1; hLCB1; HSAN1; LCB1; SPTI; HSAN; HSN1; LBC1; LCB 1; Long chain base biosynthesis protein 1; MGC14645; Serine C palmitoyltransferase; Serine palmitoyl CoA transferase 1; Serine palmitoyltransferase long chain base subunit 1; Serine palmitoyltransferase subunit 1; Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1; SPTC1_HUMAN; SPTLC 1; serine C-palmitoyltransferase
Cat.#:Sptlc1-680MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sptlc1 Protein, His-tagged
+Inquiry
Cat.#:SPTLC1-30887THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SPTLC1, His-tagged
+Inquiry
Cat.#:SPTLC1-15955MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SPTLC1 Protein
+Inquiry
Cat.#:SPTLC1-2676ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SPTLC1
+Inquiry
Cat.#:SPTLC1-1485HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SPTLC1 293 Cell Lysate
+Inquiry

Involved Pathway

SPTLC1 involved in several pathways and played different roles in them. We selected most pathways SPTLC1 participated on our site, such as Metabolic pathways, Metabolism, Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTLC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolic pathways
FUT1; UMPS; ACAA2; ABO; B4GALT6; PNP6; CYP3A7; NDUFC2; COX5B; PGLS
Metabolism
DSEL; HAS3; APOBB.1; CYB5A; CYP2K22; CES1; ISCU; NQO1; ARSE; GCKR
Metabolism of lipids and lipoproteins
PTGR1; ACOT11A; MED9; MED29; SLC25A20; ARF3; GLTP; ACSF2; CERS5; PPM1LA
Sphingolipid Metabolism
GLA; SPTLC2A; PPAP2A; SPTLC1; ARSI; VAPB; UGCG; GLTPD1; GBA; GLB1
Sphingolipid de novo biosynthesis
CERS3B; FA2H; GDF1; VAPB; COL4A3BP; OSBP; CERS5; PPM1L; PPM1LB; CERS4A
Sphingolipid signaling pathway
SPTLC3; PRKCB; SGPP1; MAP2K1; LASS2; PPP2R2B; MAP2K2; PPP2R1A; BID; PLD2
ceramide de novo biosynthesis
SPTLC1; SPTSSA

Protein Function

SPTLC1 has several biochemical functions, for example, protein binding, pyridoxal phosphate binding, serine C-palmitoyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTLC1 itself. We selected most functions SPTLC1 had, and list some proteins which have the same functions with SPTLC1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein FUT11; SCEL; LATS1; EXOC8; LGALS14; PDIA3; HEMGN; VAMP5; NKX2; HMGN2
Function pyridoxal phosphate binding
Related Protein NFS1; PDXDC1; AADAT; THNSL2; CBS; GOT1; MOCOS; SHMT2; SPTLC2A; SGPL1
Function serine C-palmitoyltransferase activity
Related Protein SPTLC1; SPTLC3; SPTLC2

Interacting Protein

SPTLC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTLC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTLC1.
RGS20; ATG4C; C20orf24; MAGED1; tsr; Bub1; Zw10; MYC; 1C; CFTR; Bmpr1a; JAK3; Ncstn; Rab5b; DYNLL1; Sptlc2; LRRK2; Atp7a; ARMC6

SPTLC1 Related Articles

Hornemann, T; Wei, Y; et al. Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?. BIOCHEMICAL JOURNAL 405:157-164(2007).