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SPTLC1

  • Official Full Name

    serine palmitoyltransferase, long chain base subunit 1

  • Overview

    Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.
  • Synonyms

    SPTLC1; serine palmitoyltransferase, long chain base subunit 1; hereditary sensory neuropathy, type 1 , HSN1; serine palmitoyltransferase 1; hLCB1; HSAN1; LCB1; SPTI; HSAN; HSN1; LBC1; LCB 1; Long chain base biosynthesis protein 1; MGC14645; Serine C palmitoyltransferase; Serine palmitoyl CoA transferase 1; Serine palmitoyltransferase long chain base subunit 1; Serine palmitoyltransferase subunit 1; Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1; SPTC1_HUMAN; SPTLC 1; serine C-palmitoyltransferase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • Myc
  • DDK
  • Flag
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SPTLC1-30887TH Recombinant Human SPTLC1, His-tagged E.coli His
Human SPTLC1-1485HCL Recombinant Human SPTLC1 293 Cell Lysate HEK293 N/A
Human SPTLC1-2092H Recombinant Human SPTLC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SPTLC1-1155HFL Recombinant Full Length Human SPTLC1 Protein, C-Flag-tagged Mammalian cells Flag
Human SPTLC1-2092H-B Recombinant Human SPTLC1 Protein Pre-coupled Magnetic Beads HEK293
Human SPTLC1-01H Recombinant Human SPTLC1 Protein, Myc/DDK-tagged HEK293T C-Myc/DDK
Mouse SPTLC1-15955M Recombinant Mouse SPTLC1 Protein Mammalian Cell His
Mouse SPTLC1-8694M Recombinant Mouse SPTLC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Sptlc1-02M Recombinant Mouse Sptlc1 Protein, Myc/DDK-tagged HEK293T C-Myc/DDK
Mouse SPTLC1-8694M-B Recombinant Mouse SPTLC1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Sptlc1-680M Recombinant Mouse Sptlc1 Protein, His-tagged E.coli His Asp143~Leu473
Mouse Sptlc1-6117M Recombinant Mouse Sptlc1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) RFL24498CF Recombinant Full Length Cricetulus Griseus Serine Palmitoyltransferase 1(Sptlc1) Protein, His-Tagged E.coli expression system His Full Length (1-473)
Homo sapiens (Human) RFL68HF Recombinant Full Length Human Serine Palmitoyltransferase 1(Sptlc1) Protein, His-Tagged E.coli expression system His Full Length (1-473)
Mus musculus (Mouse) RFL6256MF Recombinant Full Length Mouse Serine Palmitoyltransferase 1(Sptlc1) Protein, His-Tagged E.coli expression system His Full Length (1-473)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL13194PF Recombinant Full Length Pongo Abelii Serine Palmitoyltransferase 1(Sptlc1) Protein, His-Tagged E.coli expression system His Full Length (1-473)
Zebrafish SPTLC1-2676Z Recombinant Zebrafish SPTLC1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SPTLC1 Related Articles

SPTLC1 involved in several pathways and played different roles in them. We selected most pathways SPTLC1 participated on our site, such as Metabolic pathways, Metabolism, Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTLC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolic pathwaysADI1;NDUFS7;GALC;ALOX5;THTPA;AFMID;GCDHA;B3GNTL2;GDA
MetabolismSLC25A10;SLC25A11;SACM1LA;CETP;PHOSPHO1;SLC23A2;ACY3;CES1;MMADHC
Metabolism of lipids and lipoproteinsCOQ6;SPTLC1;CDIPT;G0S2;PPM1LB;PPM1LA;LPA;APOEB;CSNK1G2
Sphingolipid MetabolismENPP7;PPM1LB;SPTLC1;PPAP2D;LASS4;CERS5;ARSE;SMPD3;GDF1
Sphingolipid de novo biosynthesisGDF1;CERS4A;COL4A3BP;SGMS2;PPM1LA;ACER1;CERS3B;OSBP;VAPB
Sphingolipid signaling pathwayPLCB3;PPP2CB;GNAI3;FCER1A;MAP2K2;LOC100328615;BDKRB2;MAPK12;PPP2R1B
ceramide de novo biosynthesisSPTLC1;SPTSSA

SPTLC1 has several biochemical functions, for example, protein binding, pyridoxal phosphate binding, serine C-palmitoyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTLC1 itself. We selected most functions SPTLC1 had, and list some proteins which have the same functions with SPTLC1. You can find most of the proteins on our site.

Function Related Protein
protein bindingSORT1;TNS1;SGCA;EMP1;ACCS;CNTROB;BLOC1S6;ERRFI1;TLR13
pyridoxal phosphate bindingSHMT1;SPTLC2;ABAT;GOT1;THNSL2;Alb;HDC;NFS1;GOT2B
serine C-palmitoyltransferase activitySPTLC1;SPTLC2;SPTLC3

SPTLC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTLC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTLC1.

RGS20; ATG4C; C20orf24; MAGED1; tsr; Bub1; Zw10; MYC; 1C; CFTR; Bmpr1a; JAK3; Ncstn; Rab5b; DYNLL1; Sptlc2; LRRK2; Atp7a; ARMC6

Hornemann, T; Wei, Y; et al. Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?. BIOCHEMICAL JOURNAL 405:157-164(2007).
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