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SPTLC2

  • Official Full Name

    serine palmitoyltransferase, long chain base subunit 2

  • Overview

    This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I.
  • Synonyms

    SPTLC2; serine palmitoyltransferase, long chain base subunit 2; serine palmitoyltransferase 2; hLCB2a; KIAA0526; LCB2; LCB2A; LCB 2; Long chain base biosynthesis protein 2; Long chain base biosynthesis protein 2a; Serine palmitoyl CoA transferase 2; Serine palmitoyltransferase long chain base subunit 2; Serine palmitoyltransferase subunit II; Serine-palmitoyl-CoA transferase 2; SPT 2; SPT2; SPTC2_HUMAN; SPTLC 2; OTTHUMP00000246380; OTTHUMP00000246382; serine palmitoyltransferase, subunit II; HSN1C; NSAN1C;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SPTLC2-1484HCL Recombinant Human SPTLC2 293 Cell Lysate HEK293 N/A
Human SPTLC2-818H Recombinant Human SPTLC2 Protein (88-562 aa), His-SUMO-tagged E.coli His/SUMO 88-562 aa
Mouse SPTLC2-15956M Recombinant Mouse SPTLC2 Protein Mammalian Cell His
Mouse SPTLC2-8695M Recombinant Mouse SPTLC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Sptlc2-679M Recombinant Mouse Sptlc2 Protein, His-tagged E.coli His Glu453~Asp560
Mouse SPTLC2-8695M-B Recombinant Mouse SPTLC2 Protein Pre-coupled Magnetic Beads HEK293
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) RFL22342CF Recombinant Full Length Cricetulus Griseus Serine Palmitoyltransferase 2(Sptlc2) Protein, His-Tagged E.coli expression system His Full Length (1-560)
Homo sapiens (Human) RFL26324HF Recombinant Full Length Human Serine Palmitoyltransferase 2(Sptlc2) Protein, His-Tagged E.coli expression system His Full Length (1-562)
Mus musculus (Mouse) RFL36607MF Recombinant Full Length Mouse Serine Palmitoyltransferase 2(Sptlc2) Protein, His-Tagged E.coli expression system His Full Length (1-560)
Chicken SPTLC2-1622C Recombinant Chicken SPTLC2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

SPTLC2 involved in several pathways and played different roles in them. We selected most pathways SPTLC2 participated on our site, such as Sphingolipid metabolism, Metabolic pathways, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTLC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Sphingolipid metabolismGALCB;PPAP2CB;R05D11.9;SPTLC2B;NEU3.5;PPAP2D;CPTP;SPTLC2;ARSA
Metabolic pathwaysMAN1A2;DNMT4;B4GALT6;MTHFR;PIK3C2G;DPYS;AGXTA;GGT1A;COQ3
Sphingolipid signaling pathwayPDPK1;PLD2;ACER1;FCER1A;PRKCG;PTEN;PPP2R3C;SPTLC1;NOS3

SPTLC2 has several biochemical functions, for example, pyridoxal phosphate binding, serine C-palmitoyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTLC2 itself. We selected most functions SPTLC2 had, and list some proteins which have the same functions with SPTLC2. You can find most of the proteins on our site.

Function Related Protein
pyridoxal phosphate bindingPDXDC1;CCBL2;KYNU;DDC;HDC;ACCSL;SPTLC2;GAD2;CBS
serine C-palmitoyltransferase activitySPTLC1;SPTLC3;SPTLC2

SPTLC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTLC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTLC2.

q7chd9_yerpe; ATG2A; d-mannose; 1C; BCL6

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