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SRD5A2

  • Official Full Name

    steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)

  • Overview

    This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
  • Synonyms

    SRD5A2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2); 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha SR2; 3 oxo 5 alpha steroid 4 dehydrogenase 2; 5 alpha-SR2; 5ART2; e II 5 alpha reductase; EC; MGC138457; Micropenis, included; S5A2_HUMAN; S5AR 2; SR type 2; Steroid 5 alpha reductase 2; Steroid 5-alpha-reductase 2; Type II 5-alpha reductase; 3-oxo-5 alpha-steroid 4-dehydrogenase 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SRD5A2-81H Recombinant Human SRD5A2 protein Wheat Germ N/A
Human SRD5A2-31394TH Recombinant Human SRD5A2 Wheat Germ N/A 38 amino acids
Human SRD5A2-836H Recombinant Human SRD5A2 Mammalian Cell His
Human SRD5A2-1480HCL Recombinant Human SRD5A2 293 Cell Lysate HEK293 N/A
Human SRD5A2-2100H Recombinant Human SRD5A2 Protein, His&GST-tagged E.coli N-His&GST His90-Phe254
Human SRD5a2-1241H Recombinant Human SRD5a2 protein, His-GST-tagged E.coli His/GST Lys29~Gln71
Human SRD5A2-655HF Recombinant Full Length Human SRD5A2 Protein In Vitro Cell Free System 254 amino acids
Human SRD5A2-4144H Recombinant Human SRD5A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SRD5a2-1240H Recombinant Human SRD5a2 protein, His-GST-tagged E.coli His/GST His93~Arg145
Human SRD5A2-4144H-B Recombinant Human SRD5A2 Protein Pre-coupled Magnetic Beads HEK293
Human SRD5A2-6353H Recombinant Human SRD5A2 Protein (His90-Phe254), N-GST tagged E.coli N-GST His90-Phe254
Mouse SRD5A2-15971M Recombinant Mouse SRD5A2 Protein Mammalian Cell His
Mouse SRD5A2-8707M-B Recombinant Mouse SRD5A2 Protein Pre-coupled Magnetic Beads HEK293
Mouse SRD5A2-8707M Recombinant Mouse SRD5A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SRD5A2-5735R Recombinant Rat SRD5A2 Protein Mammalian Cell His
Rat SRD5A2-5394R Recombinant Rat SRD5A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SRD5A2-5394R-B Recombinant Rat SRD5A2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey SRD5A2-974C Recombinant Cynomolgus SRD5A2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey SRD5A2-717C-B Recombinant Cynomolgus Monkey SRD5A2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey SRD5A2-717C Recombinant Cynomolgus Monkey SRD5A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL30240HF Recombinant Full Length Human 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2(Srd5A2) Protein, His-Tagged E.coli expression system His Full Length (1-254)
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL34267MF Recombinant Full Length Macaca Fascicularis 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2(Srd5A2) Protein, His-Tagged E.coli expression system His Full Length (1-254)
Mus musculus (Mouse) RFL192MF Recombinant Full Length Mouse 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2(Srd5A2) Protein, His-Tagged E.coli expression system His Full Length (1-254)
Rattus norvegicus (Rat) RFL10292RF Recombinant Full Length Rat 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2(Srd5A2) Protein, His-Tagged E.coli expression system His Full Length (1-254)
Sus scrofa (Pig) RFL18692SF Recombinant Full Length Pig 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2(Srd5A2) Protein, His-Tagged E.coli expression system His Full Length (1-254)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SRD5A2 Related Articles

SRD5A2 involved in several pathways and played different roles in them. We selected most pathways SRD5A2 participated on our site, such as Steroid hormone biosynthesis, Prostate cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRD5A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Steroid hormone biosynthesisSULT2ST3;UGT1A6B;CYP2C54;CYP2D10;SRD5A1;HSD17B7;CYP3A7-CYP3AP1;CYP3A41B;CYP2C50
Prostate cancerMTOR;CREB3L1;PTEN;SMARCD1;TCF7;PDGFB;PIK3R2;ACTL6B;PDGFA

SRD5A2 has several biochemical functions, for example, 3-oxo-5-alpha-steroid 4-dehydrogenase activity, amide binding, cholestenone 5-alpha-reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SRD5A2 itself. We selected most functions SRD5A2 had, and list some proteins which have the same functions with SRD5A2. You can find most of the proteins on our site.

Function Related Protein
3-oxo-5-alpha-steroid 4-dehydrogenase activitySRD5A2;SRD5A2B;SRD5A2A;SRD5A1;SRD5A3;PPP1R2
amide bindingSRD5A2;PHB2
cholestenone 5-alpha-reductase activitySRD5A2;SRD5A1;SRD5A3
sterol 5-alpha reductase activity

SRD5A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRD5A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SRD5A2.

Ge, RB; Wang, ZW; et al. DNA Methyl Transferase 1 Reduces Expression of SRD5A2 in the Aging Adult Prostate. AMERICAN JOURNAL OF PATHOLOGY 185:870-882(2015).
Kon, M; Suzuki, E; et al. Molecular basis of non-syndromic hypospadias: systematic mutation screening and genome-wide copy-number analysis of 62 patients. HUMAN REPRODUCTION 30:499-506(2015).
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