srsf4
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  • Official Full Name
  • serine/arginine-rich splicing factor 4
  • Background
  • SRp75, also known as Serine/arginine-rich splicing factor 4,Is an essential splicing factor that is a member of the SR family of proteins. This protein is a component of the pre-mRNA splicing complex and is believed to play a role in alternative splice site selection. Consistent with this excess levels of SRp75 have been shown to play a role in alternative splicing of CD45. SRp75 is normally found in the nucleus and is known to be hyperphosphorylated at serine residues in its RS domain.
  • Synonyms
  • SRSF4; serine/arginine-rich splicing factor 4; SFRS4, splicing factor, arginine/serine rich 4; SR splicing factor 4; SRP75; SRP001LB; pre-mRNA-splicing factor SRP75; splicing factor, arginine/serine-rich 4; SFRS4
Cat.#:SRSF4-26856THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SRSF4
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Cat.#:SRSF4-4476RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SRSF4 Protein, His-tagged
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Cat.#:SRSF4-9977ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SRSF4
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Cat.#:SRSF4-588HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human SRSF4 lysate
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Involved Pathway

SRSF4 involved in several pathways and played different roles in them. We selected most pathways SRSF4 participated on our site, such as Spliceosome, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRSF4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Spliceosome
PRPF8; PRPF40B; SRSF2A; HNRPK; U2AF2A; DDX46; HNRNPUB; THOC1; DDX39B; HNRNPM
Herpes simplex infection
HCFC1; SRPK1; TNFB; IKBKB; TLR2-2; ARNTL; IFNGR2; TBK1; JAK2A; IL6

Protein Function

SRSF4 has several biochemical functions, for example, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRSF4 itself. We selected most functions SRSF4 had, and list some proteins which have the same functions with SRSF4. You can find most of the proteins on our site.
Function
Related Protein
Function nucleotide binding
Related Protein DHX34; MAP2K2A; MYH8; HRASA; EIF4BB; TRIO; ABCC12; SEPT7A; CPEB1A; MSI1
Function poly(A) RNA binding
Related Protein TMEM38A; PDAP1; CNBP; NOL10; RPLP0; MTO1; TCP1; KHDRBS3; ALDH18A1; SRSF3

Interacting Protein

SRSF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRSF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SRSF4.
RNPS1; YWHAG; SF3A2; SART1; HTATSF1; SRSF10; HAP1; TRA2B; SRSF2; SRSF1; SRSF6; TICAM1; ZDHHC17; PRPF38A; SRRM2; ssrna_ug

SRSF4 Related Articles

Gencheva, M; Kato, M; et al. Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing. BIOCHEMICAL JOURNAL 429:25-32(2010).
Espinosa, JM; Portal, D; et al. Trypanosoma cruzi poly-zinc finger protein: a novel DNA/RNA-binding CCHC-zinc finger protein. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 131:35-44(2003).