Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

SRSF4

Official Full Name

serine/arginine-rich splicing factor 4
Overview

SRp75, also known as Serine/arginine-rich splicing factor 4,Is an essential splicing factor that is a member of the SR family of proteins. This protein is a component of the pre-mRNA splicing complex and is believed to play a role in alternative splice site selection. Consistent with this excess levels of SRp75 have been shown to play a role in alternative splicing of CD45. SRp75 is normally found in the nucleus and is known to be hyperphosphorylated at serine residues in its RS domain.
Synonyms

SRSF4; serine/arginine-rich splicing factor 4; SFRS4, splicing factor, arginine/serine rich 4; SR splicing factor 4; SRP75; SRP001LB; pre-mRNA-splicing factor SRP75; splicing factor, arginine/serine-rich 4; SFRS4;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque
Zebrafish

Source

HEK293
Mammalian Cell
Wheat Germ

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SRSF4-26856TH	Recombinant Human SRSF4	Wheat Germ	N/A	77 amino acids	Inquiry
Human	SRSF4-588HCL	Recombinant Human SRSF4 lysate	HEK293	N/A		Inquiry
Rhesus Macaque	SRSF4-4476R	Recombinant Rhesus monkey SRSF4 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	SRSF4-4292R	Recombinant Rhesus Macaque SRSF4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	SRSF4-4292R-B	Recombinant Rhesus Macaque SRSF4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	SRSF4-9977Z	Recombinant Zebrafish SRSF4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SRSF4 Related Articles

SRSF4 involved in several pathways and played different roles in them. We selected most pathways SRSF4 participated on our site, such as Spliceosome, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRSF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Spliceosome	SART1;DHX38;SRSF4;SMNDC1;EFTUD2;SNRPC;ISY1;XAB2;LSM7
Herpes simplex infection	CCL2;IKBKE;IFNAR1;IFNG;TNFRSF14;HLA-DPA1;FASLG;GTF2IRD1;EEF1DA

SRSF4 has several biochemical functions, for example, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRSF4 itself. We selected most functions SRSF4 had, and list some proteins which have the same functions with SRSF4. You can find most of the proteins on our site.

Function	Related Protein
nucleotide binding	PABPC1L2A;OASL2;NSFB;BSK146;NEK4;EEF2A.2;HHATL;MKI67IP;ABCC12
poly(A) RNA binding	PTBP1;CCDC108;TUFM;TMEM38A;MBNL2;C7orf50;DDX24;SMG1;CDC42EP4

SRSF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRSF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SRSF4.

RNPS1; YWHAG; SF3A2; SART1; HTATSF1; SRSF10; HAP1; TRA2B; SRSF2; SRSF1; SRSF6; TICAM1; ZDHHC17; PRPF38A; SRRM2; ssrna_ug

Gencheva, M; Kato, M; et al. Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing. BIOCHEMICAL JOURNAL 429:25-32(2010).

Espinosa, JM; Portal, D; et al. Trypanosoma cruzi poly-zinc finger protein: a novel DNA/RNA-binding CCHC-zinc finger protein. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 131:35-44(2003).