AOC3
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Official Full Name
amine oxidase, copper containing 3 (vascular adhesion protein 1)
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Overview
Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone;cofactor. The product is a major protein on the adipocyte plasma membrane. It has adhesive properties and also has;functional monoamine oxidase activity. A pseudogene for this gene has been discribed and is located approximately 9-kb;downstream. -
Synonyms
AOC3; amine oxidase, copper containing 3 (vascular adhesion protein 1); HPAO; SSAO; VAP1; VAP-1; membrane primary amine oxidase; copper amine oxidase; vascular adhesion protein 1; semicarbazide-sensitive amine oxidase; EC 1.4.3.21; EC 1.4.3; Vepalimomab; 195158-85-1; Vapaliximab; 336801-86-6;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- CHO
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Sf21 Insect Cell
- Spodoptera Frugiperda
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- AOC3 Related Research Area
AOC3 involved in several pathways and played different roles in them. We selected most pathways AOC3 participated on our site, such as Glycine, serine and threonine metabolism, Tyrosine metabolism, Phenylalanine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AOC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycine, serine and threonine metabolism | CBSB;GATM;ALAS1;GLDC;CBSA;GRHPRA;AMT;PHGDH;PIPOX |
Tyrosine metabolism | HPDB;ADH2-1;IL4I1;MAOB;ADH2-2;GOT2A;DCT;COMTA;ADH1 |
Phenylalanine metabolism | MIF;GM4952;ALDH3B2;MAOA;PAH;HPDB;KEG1;AOC3;ALDH1A3 |
beta-Alanine metabolism | ALDH6A1;SMS;ALDH9A1A.1;ALDH3B2;ALDH3A2A;GAD2;GAD1;HADHA;CNDP1 |
Metabolic pathways | NDUFC2-KCTD14;DLDH;SHMT2;ATP6V0D2;DCXR;ETNK1;OAT;MAN2A1;GPAM |
AOC3 has several biochemical functions, for example, aliphatic-amine oxidase activity, aminoacetone:oxygen oxidoreductase(deaminating) activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AOC3 itself. We selected most functions AOC3 had, and list some proteins which have the same functions with AOC3. You can find most of the proteins on our site.
Function | Related Protein |
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aliphatic-amine oxidase activity | AOC2;AOC3 |
aminoacetone:oxygen oxidoreductase(deaminating) activity | AOC2;AOC3 |
calcium ion binding | PRRG3;CDH24;SLC25A25;NOTCH1A;C2CD4A;CCBE1;PCDH1G30;ASPN;PCDHGA8 |
copper ion binding | CCC2;CUTC;HEPH;MOXD1L;APOA4;MOXD1;PRNPA;SOD1;AOC1 |
phenethylamine:oxygen oxidoreductase (deaminating) activity | AOC3;AOC2 |
primary amine oxidase activity | MAOA;AOC2;VCAM1;ABP1;AOC1;MAOB;AOC3 |
protein binding | PTRH2;C7orf53;SDC4;KRT5;COL1A2;HDAC4;RPS26;GRM6;NR2E3 |
protein heterodimerization activity | UGT1A6;DR1;PPP2R1A;MTTP;STX1A;BAD;PDSS1;MPP7;GTF2A1 |
protein homodimerization activity | GCA;FGFR1OP;SPATA24;Bcl2a1b;MTHFD1L;TIRAP;KIAA1804;PON1;ATPIF1A |
quinone binding | ABP1;ETFDH;CBR4;HHIPL2;NDUFS7;TP53I3;AOC3;VKORC1;SQRDL |
tryptamine:oxygen oxidoreductase (deaminating) activity | AOC3;AOC2 |
AOC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AOC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AOC3.
MYBPC2; PRRG4
- Q&As
- Reviews
Q&As (18)
Ask a questionThere is no clear data on the use of AOC3 in children, and more research is needed to determine its safety and efficacy.
AOC3 is an important enzyme that produces human myocardial peptides, which play a key role in heart function and blood pressure regulation.
Some studies have shown that AOC3 may have a certain improvement in cardiac function, but more clinical trials are needed to verify it.
It has not been fully determined, but some possible adverse effects include allergic reactions, digestive discomfort and headaches.
There is no clear data showing that AOC3 is suitable for all patients with cardiovascular disease, and the specific application scope needs further research.
There is no clear data showing adverse interactions between AOC3 and other cardiovascular drugs, but it should be used in accordance with doctor's recommendations.
At present, AOC3 therapy is mainly administered by injection.
AOC3 has certain potential for the treatment of angina pectoris, but the specific effect needs to be further verified.
Yes, some studies have explored the potential of AOC3 in the treatment of pulmonary hypertension, but more research is needed to determine its clinical effect.
The determination of dosage is usually based on specific study design and treatment goals, and multi-center, large-sample studies are required to determine the optimal dose in clinical practice.
Clinical trials of AOC3 are ongoing to evaluate its safety and efficacy in the treatment of different diseases.
AOC3 can reduce arterial blood pressure and reduce angiotensin II activity through degradation.
There is some evidence that AOC3 may have a certain application prospect in the rehabilitation process after myocardial infarction, but more research is needed to verify its clinical effect.
Studies used in the treatment of pulmonary hypertension have shown that the therapeutic effect of AOC3 diminishes over time.
There have been academic studies showing an association between AOC3 and heart disease, and it is involved in angiotensin production, left ventricular hypertrophy and angina pectoris.
The clinical efficacy of AOC3 is usually evaluated through multicenter, randomized controlled clinical trials.
Yes, AOC3 has the potential to be used in the clinic to treat cardiovascular disease and related diseases such as hypertension.
There are currently no commercially available AOC3 drugs, but clinical trials are ongoing.
Customer Reviews (4)
Write a reviewI appreciate the Aoc3 manufacturer's attention to product quality, and their product repeatability is very good, which makes our experiment more smooth.
Aoc3 can be stored at room temperature for several days without deterioration, which allows us to easily conduct experiments and obtain reliable results.
Purity is very high, showing good production process and quality control.
Solubility of Aoc3 demonstrated well in Western blots and can be easily dissolved in a variety of buffers.
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