StAR-related lipid transfer (START) domain containing 8
This gene encodes a member of a subfamily of Rho GTPase activating proteins that contain a steroidogenic acute regulatory protein related lipid transfer domain. The encoded protein localizes to focal adhesions and may be involved in regulating cell morphology. This protein may also function as a tumor suppressor.
STARD8; StAR-related lipid transfer (START) domain containing 8; START domain containing 8; stAR-related lipid transfer protein 8; ARHGAP38; KIAA0189; Deleted in liver cancer 3; DLC3; StAR related lipid transfer protein 8; START domain containing protein 8; START GAP3; deleted in liver cancer 3 protein; STARTGAP3
STARD8 involved in several pathways and played different roles in them. We selected most pathways STARD8 participated on our site, such as Rho GTPase cycle, Signal Transduction, Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with STARD8 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
STARD8 has several biochemical functions, for example, GTPase activator activity, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STARD8 itself. We selected most functions STARD8 had, and list some proteins which have the same functions with STARD8. You can find most of the proteins on our site.
Function GTPase activator activity
Related Protein ARHGDIA; ARHGAP24; LRRK2; DOCK1; AGFG1A; ABR; ARHGAP36; SOS1; AGFG1B; AGAP1
Function lipid binding
Related Protein DOK7; ANXA6; UNC119; BPIFB3; S1PR2; O3far1; APOL2; UNC119B; SH3GLB1; APOA4B.2
STARD8 Related Articles
Holeiter, G; Bischoff, A; et al. The RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrity. ONCOGENESIS 1:-(2012).
Petit, F; Andrieux, J; et al. Xq12q13.1 microduplication encompassing the EFNB1 gene in a boy with congenital diaphragmatic hernia. EUROPEAN JOURNAL OF MEDICAL GENETICS 54:E525-E527(2011).