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SUFU

  • Official Full Name

    suppressor of fused homolog

  • Overview

    SUFU (Suppressor of Fused) was identified in Drosophila as a suppressor of the Fused (Fu) kinase that is essential for Hedgehog signaling during embryonic pattern formation (1). SUFU suppresses Hedgehog signaling by regulating the localization of the tran
  • Synonyms

    SUFU; suppressor of fused homolog (Drosophila); suppressor of fused homolog; PRO1280; SUFUH; SUFUXL;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SUFU-31479TH Recombinant Human SUFU, His-tagged E.coli His 484 amino acids
Human SUFU-3044H Recombinant Human SUFU, GST-tagged E.coli GST N-term-325aa
Human SUFU-6871H Recombinant Human Suppressor Of fused Homolog (Drosophila), His-tagged E.coli His 1-484aa
Human SUFU-1362HCL Recombinant Human SUFU 293 Cell Lysate HEK293 N/A
Human SUFU-1869H Recombinant Human SUFU Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse SUFU-16213M Recombinant Mouse SUFU Protein Mammalian Cell His
Mouse SUFU-8856M-B Recombinant Mouse SUFU Protein Pre-coupled Magnetic Beads HEK293
Mouse Sufu-6218M Recombinant Mouse Sufu Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SUFU-8856M Recombinant Mouse SUFU Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey SUFU-989C Recombinant Cynomolgus SUFU Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey SUFU-732C-B Recombinant Cynomolgus Monkey SUFU Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey SUFU-732C Recombinant Cynomolgus Monkey SUFU Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SUFU-4556R Recombinant Rhesus monkey SUFU Protein, His-tagged Mammalian Cell His
Rhesus Macaque SUFU-4372R Recombinant Rhesus Macaque SUFU Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SUFU-4372R-B Recombinant Rhesus Macaque SUFU Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SUFU-11457Z Recombinant Zebrafish SUFU Mammalian Cell His
Chicken SUFU-5837C Recombinant Chicken SUFU Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

SUFU involved in several pathways and played different roles in them. We selected most pathways SUFU participated on our site, such as Hedgehog signaling pathway, Pathways in cancer, Basal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUFU were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hedgehog signaling pathwayCSNK1G2A;CSNK1G3;SAP18;PRKACG;GLI2B;WNT2;GLI1;DYRK1A;FBXW11B
Pathways in cancerWNT11;LAMC2;FGF18;HDAC1;BIRC8;LAMB4;LPAR4;FZD7;BIRC5
Basal cell carcinomaWNT3A;FZD9;WNT16;WNT9A;WNT8B;Shh;APC2;TRP53;BMP2

SUFU has several biochemical functions, for example, protein binding, protein kinase binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SUFU itself. We selected most functions SUFU had, and list some proteins which have the same functions with SUFU. You can find most of the proteins on our site.

Function Related Protein
protein bindingCOMMD6;NEDD8;LRRC47;TSC22D3;ECHS1;KRTAP23-1;SNAP25;RNF146;RAB17
protein kinase bindingPPP1R15A;NEK6;AP2A2;GYS1;FAM83B;VRK2;ITGB2;DPYSL2;CDC25C
signal transducer activityOLFR154;CXCR4A;ADORA2AA;OLFR13;RGS9;OLFR510;TAS2R129;TICAM2;GNA13
transcription corepressor activityPAWR;CITED2;SIRT1;LHX1A;HDAC4;ATN1;GPS2;SIAH2;PBXIP1
transcription factor bindingHIF1A;DRG1;TFDP2;ATG7;DACT2;E2F4;YWHAZ;E2F5;CRY1

SUFU has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUFU here. Most of them are supplied by our site. Hope this information will be useful for your research of SUFU.

GLI1

  • Q&As
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