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SUMF2

Official Full Name

sulfatase modifying factor 2
Overview

The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms

SUMF2; sulfatase modifying factor 2; sulfatase-modifying factor 2; DKFZp566I1024; C alpha formyglycine generating enzyme 2; DKFZp66I1024; DKFZp686L17160; DKFZp781L1035; MGC99485; Paralog of the formylglycine generating enzyme; pFGE; SUMF 2; OTTHUMP00000159739; OTTHUMP00000208555; OTTHUMP00000208556; OTTHUMP00000208560; OTTHUMP00000208561; OTTHUMP00000208562; OTTHUMP00000208571; OTTHUMP00000209372; OTTHUMP00000209373; OTTHUMP00000209374; C-alpha-formyglycine-generating enzy;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mamanlian cells
Mammalian Cell
Wheat Germ

Tag

Flag
GST
His
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SUMF2-865H	Recombinant Human SUMF2	Mammalian Cell	His		Inquiry
Human	SUMF2-3055H	Recombinant Human SUMF2 protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	SUMF2-3054H	Recombinant Human SUMF2 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	SUMF2-33H	Recombinant Human SUMF2 protein, GST-tagged	Wheat Germ	GST	26 a.a. - 125 a.a.	Inquiry
Human	SUMF2-3053H	Recombinant Human SUMF2, GST-tagged	E.coli	GST	N-term-221aa	$319 / 25ug
Human	SUMF2-35H	Recombinant Human SUMF2 protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	SUMF2-1345HCL	Recombinant Human SUMF2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SUMF2-608HF	Recombinant Full Length Human SUMF2 Protein, GST-tagged	In Vitro Cell Free System	GST	301 amino acids	Inquiry
Human	SUMF2-9933HFL	Recombinant Full Length Human SUMF2 protein, Flag-tagged	Mamanlian cells	Flag		Inquiry
Human	SUMF2-4154H	Recombinant Human SUMF2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	SUMF2-4154H-B	Recombinant Human SUMF2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Sumf2-6223M	Recombinant Mouse Sumf2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	SUMF2-1505Z	Recombinant Zebrafish SUMF2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

SUMF2 involved in several pathways and played different roles in them. We selected most pathways SUMF2 participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation, Glycosphingolipid metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUMF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Gamma carboxylation, hypusine formation and arylsulfatase activation	DPH3;OTOP2;DPH2;ARSF;ATPBD4;FURINB;WDR85;F9A;PROZ
Glycosphingolipid metabolism	GLTPD1;ARSI;GLB1L;ARSH;SUMF2;GLTPA;ARSJ;GLTP;ARSD
Metabolism	PAOX;DAO;ACSF3;ARSH;SLC4A1B;CPNE7;NDUFAF4;MARCKSB;B3GNT2A
Metabolism of lipids and lipoproteins	ARF3;CPTP;SUMF2;PPM1LB;MTP;SIN3B;CYP2AD2;AKR1C21;ACOT9.2
Metabolism of proteins	NAPG;DMBT1;IGFBP2B;MAN1B1;DPP4;TOMM70A;CNIH;DPH5;IGFALS
Post-translational protein modification	EID3;THSD1;CNIH3;C8orf84;ADAMTS4;GALNTL2;RNF2;NEU4;TRAPPC2L
Sphingolipid metabolism	SGPP1;GAL3ST1A;CERS3B;ARSD;GALCB;ARSA;SPTLC2B;SGMS1;SUMF2
The activation of arylsulfatases	ARSI;ARSH;ARSK;ARSF;SUMF2;ARSJ

SUMF2 has several biochemical functions, for example, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SUMF2 itself. We selected most functions SUMF2 had, and list some proteins which have the same functions with SUMF2. You can find most of the proteins on our site.

Function	Related Protein
metal ion binding	C6AST4;ACSM5;ZFP39;TRIM41;ENDOG;ATP2C1;OVOL3;KLF11;ZFP326

SUMF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUMF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUMF2.

CACNA1A; ZFYVE9; ZDHHC17; FBXW7; env; H2AFX