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SVIL

Official Full Name

supervillin
Overview

This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described.
Synonyms

SVIL; supervillin; archvillin; p205/p250; OTTHUMP00000019388; OTTHUMP00000019389; membrane-associated F-actin binding protein p205;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SVIL-8134H	Recombinant Human SVIL protein, His-tagged	E.coli	His	Cys1385~Leu1525 (Accession # O95425)	Inquiry
Human	SVIL-1327HCL	Recombinant Human SVIL 293 Cell Lysate	HEK293	N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SVIL Related Research Area

SVIL involved in several pathways and played different roles in them. We selected most pathways SVIL participated on our site, such as Coregulation of Androgen receptor activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with SVIL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Coregulation of Androgen receptor activity	SNURF;PA2G4;NRIP1;KDM1A;TCF4;PAWR;CTDSP2;SVIL;PIAS3

SVIL has several biochemical functions, for example, actin filament binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SVIL itself. We selected most functions SVIL had, and list some proteins which have the same functions with SVIL. You can find most of the proteins on our site.

Function	Related Protein
actin filament binding	USH1C;PICK1;GAS2L2;SHROOM3;GAS7;SVILA;EZR;FLNA;MYO7A
protein binding	KCTD13;CNPY2;PIAS3;WLS;RNF149;CORO1C;FAM46B;COL6A5;UBB

SVIL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SVIL here. Most of them are supplied by our site. Hope this information will be useful for your research of SVIL.

NEB; Cdk1; Trim69; ZNF16; MYBPC3; LUC7L2; MYO1C; Flot1; CFTR; FLNA; CDK2; MYH9; MYH11; PPP1CC; IQGAP1; CAPZA2

Focal Adhesion Proteins in VSMC