SYN1
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Official Full Name
synapsin I
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Overview
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] -
Synonyms
SYN1; synapsin I; SYNI; SYN1a; SYN1b; synapsin-1; brain protein 4.1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Yeast
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- SYN1 Related Articles
- SYN1 Related Research Area
SYN1 involved in several pathways and played different roles in them. We selected most pathways SYN1 participated on our site, such as BDNF signaling pathway, Dopamine Neurotransmitter Release Cycle, Monoamine Transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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BDNF signaling pathway | DPYSL2;CSNK2A1P;BCL2L11;MAP3K2;EGR2;KCNN2;CDK5;CFL1;EGR1 |
Dopamine Neurotransmitter Release Cycle | CPLX1;CCDC167;LIN7A;Apba1;LIN7B;SYN3;SYN1;PPFIA2;UNC13B |
Monoamine Transport | SCAMP2;DBH;HRH3;FBXO32;UNC13B;SYN1;TPH2;TGFB1I1 |
Neuronal System | GJC1;DLG3;KCNMA1;PANX1;CCDC167;SLC6A12;KCNJ8;HCN4;KCNC3A |
Neurotransmitter Release Cycle | SYN1;ARL6IP5B;LIN7B;SLC6A11;SLC1A3B;Apba1;SLC1A2A;SNAP25B;RAB3AA |
Serotonin Neurotransmitter Release Cycle | PPFIA2;PPFIA4;SYN1;PPFIA1;SYN3;RERG;CPLX1;SYN2 |
Synaptic Vesicle Pathway | PARK7;SYN1;CPLX2;SYP;STX1B;DNM1L;SYN2;SYN3 |
Transmission across Chemical Synapses | Apba1;SLC1A3B;SLC1A3A;SLC1A2B;BZRAP1;ARL6IP5;SLC1A2A;SLC6A1A;SYN3 |
SYN1 has several biochemical functions, for example, ATP binding, actin binding, calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SYN1 itself. We selected most functions SYN1 had, and list some proteins which have the same functions with SYN1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | Adcy4;ABCB11;TK1;MAPK11;YSK4;INSRA;CLK3;ATAD5;MUSK |
actin binding | MYBPC2;SCIN;SSH3;EPB41L1;MYH9A;SSH2;MAEA;TNS4;CORO1A |
calcium-dependent protein binding | STMN2;PLSCR3;RBM22;PDCD6;CALM1;C9orf9;S100A11;CASQ2;S100A4 |
catalytic activity | HSD17B6;ACCSL;ACSL4B;ACSM2;RSAD2;IMPDH1B;PNP5B;PFKFB4L;PGAM1B |
protein binding | HSD17B8;TACC1;CXCR5;PMS2;TCF4;PPP1R16B;RNF135;CD151;Clec4n |
protein kinase binding | CENPJ;RHOD;SHC3;CCND2;PPP1R12B;PTPN1;HIF1A;AGAP2;TTN |
transporter activity | SLC13A4;ABCA9;FABP1B.1;ATP5O;STEAP2;RBP4L;SLCO3A1;ABCA3;SLC15A5 |
SYN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYN1.
SNCA; EGFR; VIM; RB1CC1; KAT5; LUC7L3; SAP130; PSMD2; ERI1; GTF3C2; ATG4A; DGCR8; ERGIC1; ANTXR1; VPS54
- Q&As
- Reviews
Q&As (5)
Ask a questionAltered expression or function of SYN1 has been linked to epilepsy, suggesting its potential role as a therapeutic target for managing seizure disorders.
There is emerging research suggesting that SYN1 dysfunction may be associated with schizophrenia, making it a potential target for therapeutic interventions.
Yes, SYN1 is considered a potential target for drug development in the context of neurological disorders to modulate neurotransmission and mitigate associated symptoms.
SYN1 plays a role in synaptic plasticity by influencing the dynamic regulation of synaptic vesicles, which is crucial for learning and memory processes.
Some studies suggest that alterations in SYN1 expression may contribute to synaptic dysfunction in Alzheimer's disease, making it a subject of interest for further research.
Customer Reviews (3)
Write a reviewIts purity and reliability ensure reliable and reproducible results in a variety of research applications.
The SYN1 protein exhibits outstanding performance in enzyme-linked immunosorbent assays (ELISA).
The protein's reliability and reproducibility in WB ensure accurate analysis of target proteins, while its suitability for electron microscopy structure analysis enables detailed examination of molecular structures.
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