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SYN2

Official Full Name

synapsin II
Overview

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. The TIMP4 gene is located within an intron of this gene and is transcribed in the opposite direction. Mutations in this gene may be associated with abnormal presynaptic function and schizophrenia. Alternative splicing of this gene results in two transcripts.
Synonyms

SYN2; synapsin II; synapsin-2; SYNII; SYNIIa; SYNIIb; SYN 2; SYN II; SYN IIa; SYN IIb; Synapsin 2; Synapsin II isoform IIa; Synapsin II isoform IIb; Synapsin2; SynapsinII;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

His
His (Fc)
Avi
His|T7
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SYN2-31489TH	Recombinant Human SYN2	Wheat Germ	N/A	101 amino acids	Inquiry
Human	SYN2-3071H	Recombinant Human SYN2, His-tagged	E.coli	His	233-582aa	$319 / 25ug
Mouse	SYN2-16303M	Recombinant Mouse SYN2 Protein	Mammalian Cell	His		Inquiry
Mouse	Syn2-7890M	Recombinant Mouse Syn2 protein, His & T7-tagged	E.coli	His/T7	Leu88~Thr422 (Accession # Q64332)	Inquiry
Mouse	SYN2-8909M-B	Recombinant Mouse SYN2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	SYN2-8909M	Recombinant Mouse SYN2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SYN2-5861R	Recombinant Rat SYN2 Protein	Mammalian Cell	His		Inquiry
Rat	SYN2-5520R	Recombinant Rat SYN2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	SYN2-5520R-B	Recombinant Rat SYN2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
SYN2 Related Articles

SYN2 involved in several pathways and played different roles in them. We selected most pathways SYN2 participated on our site, such as Dopamine Neurotransmitter Release Cycle, Neuronal System, Neurotransmitter Release Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Dopamine Neurotransmitter Release Cycle	LIN7A;PPFIA2;UNC13B;LIN7C;SYN3;LIN7B;SYN2;CPLX1;PPFIA1
Neuronal System	DDX1;SLC6A1B;PPFIA1;GABRR2A;KCNK2B;KCNA7;ARL6IP5A;BCHE;SLC6A12
Neurotransmitter Release Cycle	RAB3AB;PPFIA2;SLC6A11;SLC1A2B;SYN1;RAB3AA;RERG;SYN3;CPLX2L
Serotonin Neurotransmitter Release Cycle	RERG;PPFIA1;SYN2;CPLX1;PPFIA4;SYN3;PPFIA2;SYN1
Synaptic Vesicle Pathway	SYN2;STX1B;CPLX2;PARK7;DNM1L;SYN3;SYP;SYN1
Transmission across Chemical Synapses	SYN1;CPLX2L;CACFD1;SLC17A7A;GRIP1;ARL6IP5B;PPFIA4;NCALDA;SYN3

SYN2 has several biochemical functions, for example, ATP binding, catalytic activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SYN2 itself. We selected most functions SYN2 had, and list some proteins which have the same functions with SYN2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	NRK;KIF2C;DDX4;DDX18;TSSK6;HSPA1B;WARS;ILK;UBE2W
catalytic activity	ACSL4A;TPI1A;PFKMB;LGI3;ACSL4B;GNSA;APOBEC2A;ISOC2B;MTHFD1B

SYN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYN2.

IQCB1

Nagai, R; Hashimoto, R; et al. Drosophila Syntrophins are involved in locomotion and regulation of synaptic morphology. EXPERIMENTAL CELL RESEARCH 316:2313-2321(2010).

Halden, Y; Rek, A; et al. Interleukin-8 binds to syndecan-2 on human endothelial cells. BIOCHEMICAL JOURNAL 377:533-538(2004).