syne1
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  • Official Full Name
  • spectrin repeat containing, nuclear envelope 1
  • Background
  • This gene encodes a spectrin repeat containing protein expressed in skeletal and smooth muscle, and peripheral blood;lymphocytes, that localizes to the nuclear membrane. Mutations in this gene have been associated with autosomal;recessive spinocerebellar ataxia 8, also referred to as autosomal recessive cerebellar ataxia type 1 or recessive;ataxia of Beauce. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms
  • SYNE1; spectrin repeat containing, nuclear envelope 1; C6orf98, chromosome 6 open reading frame 98; nesprin-1; 8B; ARCA1; CPG2; dJ45H2.2; enaptin; KIAA0796; MYNE1; Nesprin 1; SCAR8; SYNE 1B; synaptic nuclei expressed gene 1; myocyte nuclear en
Cat.#:SYNE1-377HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SYNE1 Protein, His-tagged
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Cat.#:SYNE1-1319HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SYNE1 293 Cell Lysate
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Involved Pathway

SYNE1 involved in several pathways and played different roles in them. We selected most pathways SYNE1 participated on our site, such as Cell Cycle, Meiosis, Meiotic synapsis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYNE1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
CDC16; SKA1; CENPC1; CDKN2A; CDKN1BA; RBL1; HIST3H2BB; LEMD3; CEP290; TMEM188
Meiosis
TEX12; TERF1; DIDO1; TEX15; FKBP6; TINF2; ACD; TERF2IP; TERF2; STAG2
Meiotic synapsis
SYCE2; SYNE1; SYCP1; STAG2; SYNE2; SUN2; FKBP6; SUN1; STAG1; POT1A

Protein Function

SYNE1 has several biochemical functions, for example, actin binding, actin filament binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SYNE1 itself. We selected most functions SYNE1 had, and list some proteins which have the same functions with SYNE1. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein DST; GC; EMD; ACTR2B; PLEC; TBCCD1; VPS18; MYH15; NRAP; PARK2
Function actin filament binding
Related Protein SHROOM1; TLN1; USH1C; MYH9; DBNL; VCLA; ACTN1; SYNE2; AJUBA; VIL1
Function identical protein binding
Related Protein PKD2; POU3F2; EPS15; KCNJ2; MYD88; KDM6A; NCL; PPP5C; HCN4; AKT1
Function lamin binding
Related Protein LBR; NARF; PKP1; TMPO; PPP4C; TOR1AIP1; SUN2; PLCB1; IFI27; SUN1
Function poly(A) RNA binding
Related Protein ZCCHC8; DCAF13; HADHB; METAP2; U2SURP; PTCD2; NOC4L; CPEB3; VCP; CCBL2
Function protein binding
Related Protein FAM151B; KHDRBS2; CCBE1; TNFAIP8; DEPDC1; SMOC1; PASK; HDAC9; FAM113B; NFIX
Function protein homodimerization activity
Related Protein KCNH2; TESC; SYT16; HSD17B4; GRPEL1; CADM1A; BST2; ERBB3; GPD1C; VPS25

Interacting Protein

SYNE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYNE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYNE1.
SUN2; DISC1; Nde1; APC; p29991-pro_0000037946; MYOM1; CDC42; sdhA; tnp_8; TP53RK; q9wmx2-pro_0000037548; ere_dna