SYT1
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Official Full Name
synaptotagmin I
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Overview
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the;process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering;neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 (PubMed 11242035)). -
Synonyms
SYT1; synaptotagmin I; SVP65, SYT; synaptotagmin-1; P65; sytI; synaptotagmin 1; SYT; SVP65; DKFZp781D2042;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Aplysia californica (California sea hare)
- Chicken
- Cynomolgus Monkey
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Macaca mulatta (Rhesus macaque)
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human
- In vitro E. coli expression system
- Mammalian Cell
- Mammalian cells
- C
- His
- Myc
- DDK
- Flag
- GST
- His (Fc)
- Avi
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- SYT1 Related Articles
- SYT1 Related Research Area
SYT1 involved in several pathways and played different roles in them. We selected most pathways SYT1 participated on our site, such as Synaptic vesicle cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Synaptic vesicle cycle | SLC18A1;ATP6V1D;ATP6V1G1;CPLX4;ATP6V1C1;NSF;UNC13C;RAB3A;ATP6V0E2 |
SYT1 has several biochemical functions, for example, 1-phosphatidylinositol binding, SNARE binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SYT1 itself. We selected most functions SYT1 had, and list some proteins which have the same functions with SYT1. You can find most of the proteins on our site.
Function | Related Protein |
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1-phosphatidylinositol binding | SNAP91;SCIN;SNX9;EEA1;ZFYVE9;CCDC167;PICALMB;FRMPD2;PICALM |
SNARE binding | VTI1A;VAMP8;STX11A;STX11B.2;CCDC167;STX4A;VAMP5;GABARAPL2;UVRAG |
calcium ion binding | PSPH;CAPNS1B;PCDH2G9;SULF2;NCALDB;SLC24A4;MYL6;PCDH2G7;MYL3 |
calcium-dependent phospholipid binding | SYT7;DOC2B;SYT5;SYT5A;SYT1;SYT11A;ANXA13;ANXA2B;SYT12 |
calcium-dependent protein binding | SELP;NRXN1;KCNIP3;STX1A;SYN1;ANXA11;MYO1D;ANXA2;ANXA1 |
clathrin binding | HIP1RB;PICALMB;SYT11;SYTL1;LRRK2;AP2B1;SYT5B;SYT5;SYT12 |
low-density lipoprotein particle receptor binding | SACS;CCDC167;MMP13;LRPAP1;SNX17;CRP;LDLRAP1;APOA5;APOE |
phosphatidylinositol-4,5-bisphosphate binding | STXBP6;VIL1;FAM123A;LDLRAP1;MARK1;SNX21;RAB35;SNX18;EXOC1 |
protein binding | ZWILCH;DDA1;EIF3A;SPOPL;PGLS;PCOLCE;APOH;RBM39;C1orf187 |
syntaxin-1 binding | SNAP25;DAPK1;STXBP3A;CCDC167;STXBP2;MYO5A;RNF40;VAMP3;SLC6A4 |
SYT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYT1.
IKBKG; CACNB4; IKBKG; Syt1; ZDHHC17; PCBD1; TFCP2; CBFB; SMAD2; CACNB3; GOLM1; Caskin1; SNAPIN; Slc14a2; EPS15; STON2; COPS4
- Q&As
- Reviews
Q&As (6)
Ask a questionIn clinical practice, the expression level of SYT1 can be detected to predict the progression and prognosis of the disease, and to guide the choice of treatment regimen. For example, in the diagnosis and treatment of neurological diseases, the expression level of SYT1 can help doctors determine the type, stage and prognosis of the disease, and guide the choice of treatment regimen.
Studies have shown that SYT1 protein can participate in the regulation of antiviral immune response and affect the course of viral infection.
SYT1 protein plays an important role in the pathogenesis of certain autoimmune diseases.
Studies have shown that SYT1 protein may be associated with the pathogenesis of cardiovascular diseases such as atherosclerosis and myocardial infarction.
There is no conclusive evidence that diet can improve the nutritional status of SYT1 protein, but maintaining a balanced diet and moderate protein intake can help maintain good health.
Drug development for SYT1 is currently in clinical trials, including small molecule inhibitors against SYT1 and inhibitors against the SYT1 signaling pathway.
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