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SYT1

  • Official Full Name

    synaptotagmin I

  • Overview

    The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the;process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering;neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 (PubMed 11242035)).
  • Synonyms

    SYT1; synaptotagmin I; SVP65, SYT; synaptotagmin-1; P65; sytI; synaptotagmin 1; SYT; SVP65; DKFZp781D2042;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Aplysia californica (California sea hare)
  • Chicken
  • Cynomolgus Monkey
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human
  • In vitro E. coli expression system
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Myc
  • DDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SYT1-437H Recombinant Human Synaptotagmin I, GST-tagged E.coli GST
Human SYT1-5131H Recombinant Human Synaptotagmin I, His-tagged Human His
Human SYT1-450H Recombinant Human SYT1, His-tagged E.coli His 77-422aa
Human SYT1-3551H Recombinant Human Synaptotagmin 1, His-tagged E.coli His
Human SYT1-31492TH Recombinant Human SYT1 E.coli N/A
Human SYT1-31491TH Recombinant Human SYT1, His-tagged E.coli His 247 amino acids
Human SYT1-426HFL Active Recombinant Full Length Human SYT1 Protein, C-Flag-tagged Mammalian cells Flag
Human SYT1-3066H Recombinant Human SYT1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SYT1-6479H Recombinant Human SYT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SYT1-2149H-B Recombinant Human SYT1 Protein Pre-coupled Magnetic Beads HEK293
Human SYT1-6388H Recombinant Human SYT1 Protein (Glu136-Lys422), N-His tagged E.coli N-His Glu136-Lys422
Human SYT1-083H Recombinant Human SYT1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human SYT1-2149H Recombinant Human SYT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SYT1-2918H Recombinant Human SYT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Syt1-6256M Recombinant Mouse Syt1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat SYT1-5875R Recombinant Rat SYT1 Protein Mammalian Cell His
Rat SYT1-5534R-B Recombinant Rat SYT1 Protein Pre-coupled Magnetic Beads HEK293
Rat Syt1-2156R Recombinant Rat Syt1 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-421aa
Rat SYT1-5534R Recombinant Rat SYT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Aplysia californica (California sea hare) RFL125AF Recombinant Full Length Aplysia Californica Synaptotagmin-1(Syt1) Protein, His-Tagged E.coli expression system His Full Length (1-428)
Cynomolgus Monkey SYT1-996C Recombinant Cynomolgus SYT1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey SYT1-739C Recombinant Cynomolgus Monkey SYT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey SYT1-739C-B Recombinant Cynomolgus Monkey SYT1 Protein Pre-coupled Magnetic Beads HEK293
Gallus gallus (Chicken) RFL29931GF Recombinant Full Length Chicken Synaptotagmin-1(Syt1) Protein, His-Tagged E.coli expression system His Full Length (1-424)
Homo sapiens (Human) RFL22382HF Recombinant Full Length Human Synaptotagmin-1(Syt1) Protein, His-Tagged E.coli expression system His Full Length (1-422)
Macaca mulatta (Rhesus macaque) SYT1-5538M Recombinant Rhesus macaque SYT1 Protein (Gly98-Lys422), C-His tagged E.coli C-His Gly98-Lys422
Mus musculus (Mouse) RFL33856MF Recombinant Full Length Mouse Synaptotagmin-1(Syt1) Protein, His-Tagged E.coli expression system His Full Length (1-421)
Rattus norvegicus (Rat) RFL5829RF Recombinant Full Length Rat Synaptotagmin-1(Syt1) Protein, His-Tagged E.coli expression system His Full Length (1-421)
Rhesus Macaque SYT1-3552R Recombinant Rhesus monkey SYT1 protein, His-tagged E.coli His Gly98-Lys422
Chicken SYT1-6726C Recombinant Chicken SYT1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SYT1 Related Articles
  • SYT1 Related Research Area

SYT1 involved in several pathways and played different roles in them. We selected most pathways SYT1 participated on our site, such as Synaptic vesicle cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Synaptic vesicle cycleSLC18A1;ATP6V1D;ATP6V1G1;CPLX4;ATP6V1C1;NSF;UNC13C;RAB3A;ATP6V0E2

SYT1 has several biochemical functions, for example, 1-phosphatidylinositol binding, SNARE binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SYT1 itself. We selected most functions SYT1 had, and list some proteins which have the same functions with SYT1. You can find most of the proteins on our site.

Function Related Protein
1-phosphatidylinositol bindingSNAP91;SCIN;SNX9;EEA1;ZFYVE9;CCDC167;PICALMB;FRMPD2;PICALM
SNARE bindingVTI1A;VAMP8;STX11A;STX11B.2;CCDC167;STX4A;VAMP5;GABARAPL2;UVRAG
calcium ion bindingPSPH;CAPNS1B;PCDH2G9;SULF2;NCALDB;SLC24A4;MYL6;PCDH2G7;MYL3
calcium-dependent phospholipid bindingSYT7;DOC2B;SYT5;SYT5A;SYT1;SYT11A;ANXA13;ANXA2B;SYT12
calcium-dependent protein bindingSELP;NRXN1;KCNIP3;STX1A;SYN1;ANXA11;MYO1D;ANXA2;ANXA1
clathrin bindingHIP1RB;PICALMB;SYT11;SYTL1;LRRK2;AP2B1;SYT5B;SYT5;SYT12
low-density lipoprotein particle receptor bindingSACS;CCDC167;MMP13;LRPAP1;SNX17;CRP;LDLRAP1;APOA5;APOE
phosphatidylinositol-4,5-bisphosphate bindingSTXBP6;VIL1;FAM123A;LDLRAP1;MARK1;SNX21;RAB35;SNX18;EXOC1
protein bindingZWILCH;DDA1;EIF3A;SPOPL;PGLS;PCOLCE;APOH;RBM39;C1orf187
syntaxin-1 bindingSNAP25;DAPK1;STXBP3A;CCDC167;STXBP2;MYO5A;RNF40;VAMP3;SLC6A4

SYT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYT1.

IKBKG; CACNB4; IKBKG; Syt1; ZDHHC17; PCBD1; TFCP2; CBFB; SMAD2; CACNB3; GOLM1; Caskin1; SNAPIN; Slc14a2; EPS15; STON2; COPS4

Jung, J; Loy, K; et al. The Antidepressant Fluoxetine Mobilizes Vesicles to the Recycling Pool of Rat Hippocampal Synapses During High Activity. MOLECULAR NEUROBIOLOGY 49:916-930(2014).
Chen, CZ; Tang, Y; et al. New candidate proteins for Benzo(a)pyrene-induced spatial learning and memory deficits. JOURNAL OF TOXICOLOGICAL SCIENCES 36:163-171(2011).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How can SYT1 be used as a biomarker in clinical practice? 12/12/2022

In clinical practice, the expression level of SYT1 can be detected to predict the progression and prognosis of the disease, and to guide the choice of treatment regimen. For example, in the diagnosis and treatment of neurological diseases, the expression level of SYT1 can help doctors determine the type, stage and prognosis of the disease, and guide the choice of treatment regimen.

How is SYT1 protein related to viral infection? 04/23/2022

Studies have shown that SYT1 protein can participate in the regulation of antiviral immune response and affect the course of viral infection.

Is SYT1 protein associated with autoimmune diseases? 01/03/2022

SYT1 protein plays an important role in the pathogenesis of certain autoimmune diseases.

Is SYT1 protein associated with cardiovascular disease? 03/24/2021

Studies have shown that SYT1 protein may be associated with the pathogenesis of cardiovascular diseases such as atherosclerosis and myocardial infarction.

How can I improve the nutritional status of SYT1 protein through diet? 11/06/2020

There is no conclusive evidence that diet can improve the nutritional status of SYT1 protein, but maintaining a balanced diet and moderate protein intake can help maintain good health.

What is the current progress in drug development for SYT1? 03/12/2020

Drug development for SYT1 is currently in clinical trials, including small molecule inhibitors against SYT1 and inhibitors against the SYT1 signaling pathway.

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