syt1
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  • Official Full Name
  • synaptotagmin I
  • Background
  • The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the;process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering;neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 (PubMed 11242035)).
  • Synonyms
  • SYT1; synaptotagmin I; SVP65, SYT; synaptotagmin-1; P65; sytI; synaptotagmin 1; SYT; SVP65; DKFZp781D2042
Cat.#:SYT1-3066HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SYT1 Protein, MYC/DDK-tagged
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Cat.#:SYT1-31491THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SYT1, His-tagged
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Cat.#:SYT1-31492THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SYT1
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Cat.#:SYT1-3551HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Synaptotagmin 1, His-tagged
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Cat.#:SYT1-437HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Synaptotagmin I, GST-tagged
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Cat.#:SYT1-450HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SYT1, His-tagged
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Cat.#:SYT1-5875RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SYT1 Protein
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Cat.#:SYT1-996CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus SYT1 Protein, His-tagged
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Cat.#:SYT1-3552RTag:His
Source (Host):E. coliSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SYT1 protein, His-tagged
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Cat.#:SYT1-6726CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SYT1
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Cat.#:SYT1-5131HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Synaptotagmin I, His-tagged
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Involved Pathway

SYT1 involved in several pathways and played different roles in them. We selected most pathways SYT1 participated on our site, such as Synaptic vesicle cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Synaptic vesicle cycle
ATP6V1D; ATP6V0D1; ATP6V0E1; RIMS1; CPLX4; STX3; ATP6V1B1; UNC13A; ATP6V1F; ATP6V0C

Protein Function

SYT1 has several biochemical functions, for example, 1-phosphatidylinositol binding, SNARE binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SYT1 itself. We selected most functions SYT1 had, and list some proteins which have the same functions with SYT1. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol binding
Related Protein CCDC167; WDFY3; PICALMB; PLEKHA4; SNX9; ZFYVE9; PICALMA; EEA1; FRMPD2; SCARB1
Function SNARE binding
Related Protein GOSR1; SEC22A; VAMP5; STXBP1; STX3A; STX11B.2; GABARAPL2; UNC13A; TNFAIP2; GOSR2
Function calcium ion binding
Related Protein CD248A; PVALB8; ANXA5; PCDHA10; APCS; GCH1; PRRG2; EMR1; MACF1; PCDH1G29
Function calcium-dependent phospholipid binding
Related Protein ANXA3B; SYT5; ANXA6; ANXA2B; SYT2; ANXA4; ANXA13L; ANXA5; ANXA11B; SYT12
Function calcium-dependent protein binding
Related Protein PLSCR3; MBL2; RBM22; SNAP25; TNNT3; ANXA7; S100P; CPNE3; ANXA1; CHP
Function clathrin binding
Related Protein SYT11; HIP1RB; SYT15; CCDC167; SYT9B; PICALMB; SYT1; SYT8; SMAP1; SYT12
Function low-density lipoprotein particle receptor binding
Related Protein SYT1; SNX17; HSP90B1; SLC9A3R2; APOE; MMP13; CRP; ARRB2; APOEA; DNAJA1
Function phosphatidylinositol-4,5-bisphosphate binding
Related Protein SYT1; ANXA8; CCDC167; FRMPD4; Apba1; SYTL2; LDLRAP1; KRIT1; FAM21C; KCNJ2
Function protein binding
Related Protein FSCN1; PSAP; PLEKHG6; VRK2; PARN; TCF12; SNTB2; SYNM; SLC25A46; MOCOS
Function syntaxin-1 binding
Related Protein SYBU; DAPK1; SNAP25A; VAMP3; LRRK2; STXBP2; STXBP1; VAMP2; GOLSYN; STXBP3

Interacting Protein

SYT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYT1.
IKBKG; CACNB4; IKBKG; Syt1; ZDHHC17; PCBD1; TFCP2; CBFB; SMAD2; CACNB3; GOLM1; Caskin1; SNAPIN; Slc14a2; EPS15; STON2; COPS4

SYT1 Related Articles

Jung, J; Loy, K; et al. The Antidepressant Fluoxetine Mobilizes Vesicles to the Recycling Pool of Rat Hippocampal Synapses During High Activity. MOLECULAR NEUROBIOLOGY 49:916-930(2014).
Chen, CZ; Tang, Y; et al. New candidate proteins for Benzo(a)pyrene-induced spatial learning and memory deficits. JOURNAL OF TOXICOLOGICAL SCIENCES 36:163-171(2011).