syt2
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  • Official Full Name
  • synaptotagmin II
  • Background
  • Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in;the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 (PubMed 8058779)).
  • Synonyms
  • SYT2; synaptotagmin II; synaptotagmin-2; Synaptotagmin 2; Synaptotagmin2; SynaptotagminII; SYT 2; Syt II; SYT2_HUMAN; SytII
Cat.#:SYT2-3083HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SYT2, GST-tagged
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Cat.#:SYT2-35HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SYT2 protein, MYC/DDK-tagged
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Cat.#:SYT2-16334MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SYT2 Protein
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Cat.#:SYT2-5880RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SYT2 Protein
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Cat.#:SYT2-4590RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SYT2 Protein, His-tagged
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Cat.#:SYT2-646HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human SYT2 lysate
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Involved Pathway

SYT2 involved in several pathways and played different roles in them. We selected most pathways SYT2 participated on our site, such as Disease, Infectious disease, Neurotoxicity of clostridium toxins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Disease
CTBP1; RLBP1; FDX1; HDAC6; TIRAP; NPM1; MTRR; DPF1; TICAM1; LTF
Infectious disease
AP1M2; KPNA5; STX1B; AP1G1; KPNA4; DOCK2; ANTXR1; LTF; PDCD6IP; ANTXR2
Neurotoxicity of clostridium toxins
SYT2; STX1B
Toxicity of botulinum toxin type B (BoNT/B)
SYT2
Uptake and actions of bacterial toxins
PDCD6IP; ANTXR1; ANTXR2; SYT2

Protein Function

SYT2 has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipid binding, clathrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SYT2 itself. We selected most functions SYT2 had, and list some proteins which have the same functions with SYT2. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein FAT1A; PCDH15; SYT5A; CANT1A; CD93; S100G; CRACR2B; PVALB6; SLIT1B; CDH11
Function calcium-dependent phospholipid binding
Related Protein SYTL4; ANXA11; PLA2G4B; SYT1A; DOC2B; SYT5B; RPH3A; ANXA13; SYT10; PLA2G4A
Function clathrin binding
Related Protein CLINT1; PICALM; SYT11A; SYT9; HIP1RB; SYT11; CCDC167; AP2B1; SYT7; SYT17
Function inositol 1,3,4,5 tetrakisphosphate binding
Related Protein ADAP2; ADAP1; SYT2; ITPR3; AKR1C1
Function protein binding
Related Protein ETV5; DNAJB5; RASSF7; TAB1; KRT6A; HPS6; STATH; EDEM1; AGRN; PLOD3
Function syntaxin binding
Related Protein TMED9; STXBP3A; TXLNBB; NAPB; RAB4A; STXBP1; SYT11A; SYT15; STXBP3; NAPG

Interacting Protein

SYT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYT2.
HTT; PAUF; TGOLN2; PRKD2

SYT2 Related Articles

Neumann, S; Haverkamp, S; et al. Characterization of small-field bistratified amacrine cells in macaque retina labeled by antibodies against synaptotagmin-2. JOURNAL OF COMPARATIVE NEUROLOGY 521:709-724(2013).
Monterrat, C; Boal, F; et al. Synaptotagmin 8 is expressed both as a calcium-insensitive soluble and membrane protein in neurons, neuroendocrine and endocrine cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1763:73-81(2006).
HILBUSH, BS; MORGAN, JI; et al. A 3RD SYNAPTOTAGMIN GENE, SYT3, IN THE MOUSE. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91:8195-8199(1994).