syt5
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  • Official Full Name
  • synaptotagmin V
  • Background
  • Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related;to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may;act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium;receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 (PubMed 7597049)).
  • Synonyms
  • SYT5; synaptotagmin V; synaptotagmin-5; synaptotagmin 5; sytV
Cat.#:SYT5-307HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human synaptotagmin V, His-tagged
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Cat.#:SYT5-3086HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SYT5, His-tagged
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Cat.#:SYT5-31493THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SYT5, His-tagged
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Cat.#:SYT5-16337MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SYT5 Protein
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Cat.#:SYT5-5883RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SYT5 Protein
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Cat.#:SYT5-1303HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SYT5 293 Cell Lysate
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Involved Pathway

SYT5 involved in several pathways and played different roles in them. We selected most pathways SYT5 participated on our site, such as Integration of energy metabolism, Metabolism, Regulation of insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Integration of energy metabolism
AKAP5; KCNJ11; ARL2; GNG13B; KCNB1; RAPGEF3; GNG13A; RAPGEF4; KCNS3A; MARCKSA
Metabolism
HIBADH; EPM2A; SLC27A2A; MED9; DBH; CPNE6; FA2H; ETFB; NEU4; ACOT2
Regulation of insulin secretion
ARL2BP; MARCKSB; KCNS3A; SYT5; KCNB1; KCNS3; MARCKSA; KCNC2; ARL2

Protein Function

SYT5 has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipid binding, clathrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SYT5 itself. We selected most functions SYT5 had, and list some proteins which have the same functions with SYT5. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein CDHR1; MYL13; TBC1D8B; MMP14; CAPNS1A; PCDH1; GUCA1A; PCDHB16; PCDH1G30; PLA2G4B
Function calcium-dependent phospholipid binding
Related Protein SYT7; SYT11A; ANXA5A; CPNE3; ANXA13L; ANXA5; ANXA9; ANXA1C; SYT1B; SYT12
Function clathrin binding
Related Protein PICALMB; SYT2; SYT9; SYT16; SYT12; SYT10; SYTL2; PICALMA; SYT15; SYT5B
Function protein heterodimerization activity
Related Protein HIST1H2B5; TLR2; HER1; PVALB; ADRA2A; SLC51B; DDIT3; H2AFY; BCL11A; BMP2B
Function syntaxin binding
Related Protein STXBP3; SNAP23.2; SNAP23; RPH3AL; CPLX4; SYT6; STX8; RAB4A; VPS52; CPLX2L

Interacting Protein

SYT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYT5.
POLR2E; RAB1A

SYT5 Related Articles

Strotmeier, J; Mahrhold, S; et al. Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A. FEBS LETTERS 588:1087-1093(2014).
Stafford, JH; Hao, GY; et al. Highly Specific PET Imaging of Prostate Tumors in Mice with an Iodine-124-Labeled Antibody Fragment That Targets Phosphatidylserine. PLOS ONE 8:-(2013).