SYVN1
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Official Full Name
synovial apoptosis inhibitor 1, synoviolin
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Overview
This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. -
Synonyms
SYVN1; synovial apoptosis inhibitor 1, synoviolin; E3 ubiquitin-protein ligase synoviolin; HRD1; KIAA1810; MGC40372;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Danio rerio (Zebrafish) (Brachydanio rerio)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- His|SUMO
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- SYVN1 Related Articles
SYVN1 involved in several pathways and played different roles in them. We selected most pathways SYVN1 participated on our site, such as Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYVN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | CBLC;UBE3A;UBE2G1;UBE2G2;CUL3;BIRC7;RHOBTB2A;UBE2E1;CDC20 |
| Protein processing in endoplasmic reticulum | ERO1LB;UBE2D3;SEC24C;MAP3K5;DNAJC5B;SEL1L2;DNAJB12;BAG1;BAX |
SYVN1 has several biochemical functions, for example, ATPase binding, chaperone binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SYVN1 itself. We selected most functions SYVN1 had, and list some proteins which have the same functions with SYVN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase binding | FXYD3;ATP1B1;ATP6V0A4;SNX10;ATP6V1G3;FAM119A;SVIP;ATP6V0A1A;TAF9 |
| chaperone binding | BAG2;DNAJA3B;TP53;PIH1D3;DNAJA4;H2-KE2;ATP1A3;GRPEL2;HSPA5 |
| ligase activity | NEDD4;RNF19A;HECW2;UBE2G1A;PIAS2;TRIM13;DZIP3;ARIH2;RNF220 |
| protein binding | NTF4;HSP90AA1;MEOX2;NXT2;TRPC4AP;HNRPDL;TDP2;AURKB;ARHGEF16 |
| ubiquitin protein ligase activity | MSL2A;CDK8;PDZRN4;RNF111;PDZRN3;MGRN1;RNF13;UBE2T;MED21 |
| ubiquitin protein ligase activity involved in ERAD pathway | STUB1;RNF5;RNF185;SYVN1;AMFR;TRIM25;PARK2;TMEM129 |
| ubiquitin-specific protease binding | CHMP3;SART3;RAD23A;BAG6;SELS;SYVN1;AMFR;DERL1;PARK2 |
| unfolded protein binding | CHAF1A;AIP;APCS;CANX;CCT7;TUBB4B;HSPA1B;HSPE1;ERLEC1 |
| zinc ion binding | QPCT;DNPEP;ZDHHC2;MICALL2B;TRIM3;SF3A2;ZNF331;TRIM27;CHD4 |
SYVN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYVN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYVN1.
TP53; ERN1; VCP; UBXN6; ATN1; q5ne83_fratt; gltX; ftsZ; UBE2U; frwC; ezrA; q81wx2_bacan; q8cki1_yerpe; kefB
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