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SCARB2

  • Official Full Name

    scavenger receptor class B, member 2

  • Overview

    The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
  • Synonyms

    SCARB2; scavenger receptor class B, member 2; AMRF; EPM4; LGP85; CD36L2; HLGP85; LIMP-2; LIMPII; SR-BII; lysosome membrane protein 2; LIMP II; CD36 antigen-like 2; lysosome membrane protein II; 85 kDa lysosomal membrane sialoglycoprotein; 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E. coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • Fc
  • His
  • Fc|His
  • Flag
  • hFc
  • His (Fc)
  • Avi
  • human|IgG1|Fc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SCARB2-850H Recombinant Human SCARB2, Fc-His tagged Human Cell Fc/His
Human SCARB2-2752HCL Recombinant Human SCARB2 cell lysate Human Cell N/A
Human SCARB2-0723H Recombinant Human SCARB2 protein, Fc-tagged HEK293 Fc Arg27-Thr432
Human SCARB2-2029H Recombinant Human SCARB2 Protein, Fc/His-tagged HEK293 Fc/His Arg27-Thr432
Human SCARB2-6629H Recombinant Human SCARB2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SCARB2-470H Recombinant Human SCARB2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SCARB2-2867H Recombinant Human SCARB2 protein(71-180 aa), C-His-tagged E. coli C-His 71-180 aa
Human SCARB2-1959H Recombinant Human SCARB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SCARB2-437H Recombinant Human SCARB2 Protein, Fc-tagged HEK293 Fc 478
Human SCARB2-323H Recombinant Human SCARB2 protein, Fc-tagged HEK293 human/IgG1/Fc 406
Human SCARB2-2663H Recombinant Human SCARB2 protein, His-tagged HEK293 His Arg27-Thr432
Human SCARB2-2621H Active Recombinant Human SCARB2 protein, hFc&His-tagged HEK293 hFc&His Arg27-Thr432
Human SCARB2-1959H-B Recombinant Human SCARB2 Protein Pre-coupled Magnetic Beads HEK293
Human SCARB2-2073HFL Recombinant Full Length Human SCARB2 Protein, C-Flag-tagged Mammalian cells Flag
Human SCARB2-2188H Active Recombinant Human SCARB2 protein, His&hFc-tagged HEK293 His&hFc Arg27-Thr432
Human SCARB2-6708H Recombinant Human SCARB2 Protein (Arg27-Thr432), C-His tagged Mammalian cells C-His Arg27-Thr432
Mouse Scarb2-948M Active Recombinant Mouse Scarb2 Protein, Fc Chimera Mammalian cells Fc
Mouse Scarb2-3999M Recombinant Mouse Scarb2 protein, His-tagged HEK293 His Met1-Thr432
Mouse Scarb2-851M Recombinant Mouse scavenger receptor class B, member 2, His-tagged HEK293 His
Mouse SCARB2-2413MCL Recombinant Mouse SCARB2 cell lysate Human Cell N/A
Mouse Scarb2-103M Recombinant Mouse Scarb2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Scarb2-835M Recombinant Mouse Scarb2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Scarb2-5621M Recombinant Mouse Scarb2 Protein (Arg27-Thr432), C-His tagged Mammalian cells C-His Arg27-Thr432
Mouse Scarb2-5620M Recombinant Mouse Scarb2 Protein (Arg27-Thr432), C-Fc tagged Mammalian cells C-Fc Arg27-Thr432
Mouse Scarb2-103M-B Recombinant Mouse Scarb2 Protein Pre-coupled Magnetic Beads HEK293
Rat SCARB2-5244R Recombinant Rat SCARB2 Protein Mammalian Cell His
Rat SCARB2-4903R Recombinant Rat SCARB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SCARB2-4903R-B Recombinant Rat SCARB2 Protein Pre-coupled Magnetic Beads HEK293
Mus musculus (Mouse) RFL22231MF Recombinant Full Length Mouse Lysosome Membrane Protein 2(Scarb2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-478)
Rattus norvegicus (Rat) RFL4155RF Recombinant Full Length Rat Lysosome Membrane Protein 2(Scarb2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-478)
Zebrafish SCARB2-9532Z Recombinant Zebrafish SCARB2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SCARB2 Related Articles

SCARB2 involved in several pathways and played different roles in them. We selected most pathways SCARB2 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCARB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
LysosomeATP6V0A2;Abca2;CTSG;AP3D1;ACP5;NAPSA;GNPTG;GNPTAB;SCARB2

SCARB2 has several biochemical functions, for example, enzyme binding, protein binding, virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SCARB2 itself. We selected most functions SCARB2 had, and list some proteins which have the same functions with SCARB2. You can find most of the proteins on our site.

Function Related Protein
enzyme bindingEHHADH;RCOR3;BIRC5;HINFP;EIF2AK3;BLZF1;TSPYL1;ATG3;HDAC3
protein bindingPIWIL1;PDLIM3;GLRA1;CERK;PAWR;IK;NR2C2;ARSA;FAF1
virus receptor activityMRC1;RPSA;SLC10A1;NCAM1;TYRO3;CR2;CD209;CLEC4M;DPP4

SCARB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCARB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCARB2.

Gba; PLCG1; CSK; CAV1; q7cj43_yerpe; b3xyc5_sollc; pi3p; A2M; cona_canen; EIF2AK2; ATP6V1A; PRPF8; PNKD; SMC6; MYOF

Fink, IR; Benard, EL; et al. Molecular and functional characterization of the scavenger receptor CD36 in zebrafish and common carp. MOLECULAR IMMUNOLOGY 63:381-393(2015).
Fu, YJ; Aida, I; et al. Progressive myoclonus epilepsy: extraneuronal brown pigment deposition and system neurodegeneration in the brains of Japanese patients with novel SCARB2 mutations. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 40:551-563(2014).
  • Q&As
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