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SF3B3

  • Official Full Name

    splicing factor 3b, subunit 3, 130kDa

  • Overview

    This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the introns branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
  • Synonyms

    SF3B3; splicing factor 3b, subunit 3, 130kDa; splicing factor 3b, subunit 3, 130kD; splicing factor 3B subunit 3; KIAA0017; RSE1; SAP130; SF3b130; SAP 130; OTTHUMP00000174907; spliceosome-associated protein 130; pre-mRNA-splicing factor SF3b 130 kDa subunit; pre-mRNA splicing factor SF3b, 130 kDa subunit; STAF130;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293 Cells
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • Strep
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SF3B3-2613H Recombinant Human SF3B3, His-tagged E.coli His 250-399aa
Human SF3B3-1916HCL Recombinant Human SF3B3 293 Cell Lysate HEK293 N/A
Human SF3B3-1990H Recombinant Human SF3B3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SF3B3-2509H Recombinant Human SF3B3 Protein, MYC/DDK-tagged HEK293 Cells Myc/DDK
Human SF3B3-0591H Recombinant Human SF3B3 Protein (F2-F1217), His/Strep tagged Insect Cell His/Strep F2-F1217
Human SF3B3-1145H Recombinant Human SF3B3 protein, His&Myc-tagged E.coli His&Myc 819-1217aa
Human SF3B3-2248H Recombinant Human SF3B3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SF3B3-71HFL Recombinant Full Length Human SF3B3 Protein, C-Flag-tagged Mammalian cells Flag
Human SF3B3-0590H Recombinant Human SF3B3 Protein (F2-F1217), Tag Free Insect Cell No tag F2-F1217
Human SF3B3-1990H-B Recombinant Human SF3B3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Sf3b3-23M Recombinant Mouse Sf3b3 Protein, His-tagged E.coli His
Mouse Sf3b3-194M Recombinant Mouse Sf3b3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Zebrafish SF3B3-12665Z Recombinant Zebrafish SF3B3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SF3B3 Related Articles

SF3B3 involved in several pathways and played different roles in them. We selected most pathways SF3B3 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SF3B3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
SpliceosomePRPF3;HSPA1A;MAGOH;HNRNPA1;NCBP2;RBM8A;HSP70L;HNRNPA1A;RBMX

SF3B3 has several biochemical functions, for example, RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SF3B3 itself. We selected most functions SF3B3 had, and list some proteins which have the same functions with SF3B3. You can find most of the proteins on our site.

Function Related Protein
RNA bindingCELF3A;ENDOU;NOL3;ILF3B;WDHD1;RPL31;TTC6;DNAJC17;IFIT3
protein bindingDCDC2B;CCT4;SPINLW1;FOXK1;SMARCD3;TP53BP1;KNG1;NPBWR1;USP33

SF3B3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SF3B3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SF3B3.

YWHAG; ESR2; NUDCD3; b4dyc6_human; DEGS1; CFLAR; NCOR1; WBP4; SMNDC1; HSP90AB1; HCK; YWHAZ; SNRPN; RNPS1; SF3A2; Sf3a1; q96be0_human

Yang, G; Holl, TM; et al. Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. JOURNAL OF EXPERIMENTAL MEDICINE 210:241-256(2013).
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