sfrp1
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  • Official Full Name
  • secreted frizzled-related protein 1
  • Background
  • This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
  • Synonyms
  • SFRP1; secreted frizzled-related protein 1; FRP; FRP1; FrzA; FRP-1; SARP2; SARP-2; sFRP-1; secreted apoptosis-related protein 2;
Cat.#:SFRP1-790MTag:His
Source (Host):CHO Stable CellsSpecies:Mouse
Product nameRecombinant Mouse SFRP1 Protein (Met1-Lys314), His-tagged
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Cat.#:SFRP1-364HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SFRP1 Protein, His-tagged
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Cat.#:Sfrp1-365MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sfrp1 Protein, His-tagged
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Cat.#:Sfrp1-366RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sfrp1 Protein, His-tagged
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Cat.#:SFRP1-221HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human SFRP1, His-tagged
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Cat.#:SFRP1-222HTag:
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human SFRP1
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Cat.#:SFRP1-2704HTag:N/A
Source (Host):HeLa cellsSpecies:Human
Product nameRecombinant Human Secreted Frizzled-related Protein 1
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Cat.#:SFRP1-672HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human SFRP1, Fc-tagged, Biotinylated
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Cat.#:SFRP1-673HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human SFRP1, Fc-tagged
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Cat.#:SFRP1-8311HTag:
Source (Host):HeLa cellsSpecies:Human
Product nameRecombinant Human SFRP1
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Cat.#:SFRP1-859HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SFRP1, His tagged
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Cat.#:Sfrp1-860MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Sfrp1, His tagged
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Cat.#:Sfrp1-861RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Sfrp1, Fc tagged
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Cat.#:SFRP1-4173RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SFRP1 Protein, His-tagged
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Cat.#:SFRP1-6122CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SFRP1
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Cat.#:SFRP1-2853HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human SFRP1 cell lysate
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Cat.#:SFRP1-2852MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse SFRP1 cell lysate
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Involved Pathway

SFRP1 involved in several pathways and played different roles in them. We selected most pathways SFRP1 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SFRP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
DKK1B; WNT9B; CAMK2D; TP53; WNT11R; PLCB4; TBL1Y; DAAM1B; INVS; PPP3CC

Protein Function

SFRP1 has several biochemical functions, for example, NOT G-protein coupled receptor activity, NOT Wnt-activated receptor activity, Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SFRP1 itself. We selected most functions SFRP1 had, and list some proteins which have the same functions with SFRP1. You can find most of the proteins on our site.
Function
Related Protein
Function NOT G-protein coupled receptor activity
Related Protein LGR4; LGR5; FRZB; SFRP1A; LGR6; SZL; SFRP4; SFRP1; SFRP1B; SFRP2
Function NOT Wnt-activated receptor activity
Related Protein SETD6; SFRP1; SZL; FRZB; SFRP1B; SFRP2; SFRP1A; SFRP4; TSPAN12; SMO
Function Wnt-protein binding
Related Protein SFRP1A; FZD8B; SMO; SZL; GM12824; FZD1; FZD10; FZD9B; SFRP1; LRP6
Function cysteine-type endopeptidase activity
Related Protein CTSSB.1; USP47; USP20; USP12; CASP14; USP25; ATG4C; USP18; CASP3B; USP16
Function drug binding
Related Protein SMO; ADH1; TYMS; PDE2A; TLR8; CHRNB3; SRP54B; MT3; DHODH; DHFR
Function frizzled binding
Related Protein WNT2; WNT2BB; WNT8A; WNT4B; WNT8B; DVL1B; SFRP1; WNT7AA; WNT4A; WNT7A
Function heparin binding
Related Protein FGF1; VEGFB; LIPC; CXCL11; SLIT1B; WISP1; FGF4; THBS2; NRP1A; FGFR1A
Function identical protein binding
Related Protein GOT2; DYNLT1F; LYZ2; C10orf88; ZBTB16; TPCN2; RABAC1; DYNLT1B; ASS1; VPS41
Function protein binding
Related Protein FAM164C; MSLN; CTCFL; PLEKHF2; KBTBD6; LAMA1; SPRTN; SEC23B; ARSA; CCL11

Interacting Protein

SFRP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SFRP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SFRP1.
FZD6; WNT2; KIAA1522

SFRP1 Related Articles

Ghoshal, A; Ghosh, SS; et al. Expression, Purification, and Therapeutic Implications of Recombinant sFRP1. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 175:2087-2103(2015).
Whyte, MP; Madson, KL; et al. Rapid Skeletal Turnover in a Radiographic Mimic of Osteopetrosis. JOURNAL OF BONE AND MINERAL RESEARCH 29:2601-2609(2014).