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SGCA

Official Full Name

sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
Overview

This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

SGCA; sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); ADL, sarcoglycan, alpha (50kD dystrophin associated glycoprotein); alpha-sarcoglycan; 50kD DAG; A2; adhalin; adhalin (limb girdle muscular dystrophy 2D); DMDA2; LGMD2D; Sarcoglycan; alpha (50kD dystrophin associated glycoprotein; adhalin); SCARMD1; 50DAG; 59kDa; ADL; DAG2; 50 DAG; 50 kDa dystrophin associated glycoprotein; 50 kDa dystrophin-associated glycoprotein; Alpha SG; Alpha-SG; Asg; Dystroglycan 2; Dystroglycan-2; sarcoglycan, alpha (dystrophin-associated glycoprotein); SGCA_HUMAN; OTTHUMP00000221051; OTTHUMP00000221052; OTTHUMP00000221053; 50-DAG;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Mus musculus (Mouse)

Source

E.coli
E.coli expression system
E.Coli or Yeast
HEK293
HEK293T
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

Flag
His
His (Fc)
Avi
His|GST
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SGCA-27337TH	Recombinant Human SGCA	Wheat Germ	N/A	108 amino acids	Inquiry
Human	SGCA-1890HCL	Recombinant Human SGCA 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SGCA-1669H	Recombinant Human SGCA protein, His & GST-tagged	E.coli	His/GST	Gln24~His387 (Accession # Q16586)	Inquiry
Human	SGCA-02H	Recombinant Human SGCA Protein, Myc/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	SGCA-01H	Recombinant Human SGCA Protein, Myc/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	SGCA-3498H	Recombinant Human SGCA protein, His-tagged	E.coli	His	24-105 aa	$319 / 25ug
Human	SGCA-545HFL	Recombinant Full Length Human SGCA Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	SGCA-1994H-B	Recombinant Human SGCA Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	SGCA-1994H	Recombinant Human SGCA Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	SGCA-15028M	Recombinant Mouse SGCA Protein	Mammalian Cell	His		Inquiry
Mouse	Sgca-3387M	Recombinant Mouse Sgca, His-tagged	E.Coli or Yeast	His	387	Inquiry
Mouse	SGCA-8095M-B	Recombinant Mouse SGCA Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Sgca-5820M	Recombinant Mouse Sgca Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	SGCA-8095M	Recombinant Mouse SGCA Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mus musculus (Mouse)	RFL18226MF	Recombinant Full Length Mouse Alpha-Sarcoglycan(Sgca) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (24-387)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
SGCA Related Research Area

SGCA involved in several pathways and played different roles in them. We selected most pathways SGCA participated on our site, such as Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, which may be useful for your reference. Also, other proteins which involved in the same pathway with SGCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Hypertrophic cardiomyopathy (HCM)	PRKAA2;ITGA8;CACNG3;TPM4;SGCB;PRKAB1;ACE;PRKAB2;SGCA
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	EMD;CACNG6;CACNG2;AASS;JUP;ITGA4;ITGA8;ACTN3;ITGAV
Dilated cardiomyopathy	LAMA2;CACNB1;ITGB5;ITGB1;ITGA3;RYR2;PRKACG;ACTG1;ITGB6
Viral myocarditis	PRF1;SGCB;CD86;EIF4G2;RAC2;CD40;H2-Q10;HLA-DOA;SGCG

SGCA has several biochemical functions, for example, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SGCA itself. We selected most functions SGCA had, and list some proteins which have the same functions with SGCA. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	MMP15;FSTL5;SLIT1B;KIAA0494;MAN1A1;BNIP2;CLSTN1;PADI4;DSG2.1
protein binding	SPRR2A;NOL9;FAT4;STK3;ARID5A;KIAA0368;FAM50B;PHF23;ACVR2A

SGCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SGCA here. Most of them are supplied by our site. Hope this information will be useful for your research of SGCA.

SGTA; FN1; TAF1; FSTL1; ITGB1BP2

Cardiac Stem Cell Markers

Proteoglycans

Myogenesis Markers

Skeletal Muscle Markers