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Shank2

Official Full Name

SH3 and multiple ankyrin repeat domains 2
Synonyms

SHANK2;SH3 and multiple ankyrin repeat domains 2;ENSRNOG00000029931;CortBP1;ProSAP1;Spank-3;1q41;SH3 and multiple ankyrin repeat domains protein 2;SH3 and multiple ankyrin repeat domains protein 2;SH3/ankyrin domain gene 2;cortactin-binding protein 1;GKAP/SAPAP-interacting protein;proline rich synapse associated protein 1;proline-rich synapse-associated protein 1;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Mouse
Rat
Zebrafish

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	SHANK2-15085M	Recombinant Mouse SHANK2 Protein	Mammalian Cell	His	Inquiry
Mouse	SHANK2-8136M	Recombinant Mouse SHANK2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	SHANK2-8136M-B	Recombinant Mouse SHANK2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rat	SHANK2-5386R	Recombinant Rat SHANK2 Protein	Mammalian Cell	His	Inquiry
Rat	SHANK2-5045R	Recombinant Rat SHANK2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	SHANK2-5045R-B	Recombinant Rat SHANK2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	SHANK2-6859Z	Recombinant Zebrafish SHANK2	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Shank2 Related Articles
Shank2 Related Research Area

Shank2 involved in several pathways and played different roles in them. We selected most pathways Shank2 participated on our site, such as Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Shank2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glutamatergic synapse	GNAI1;GRIN2B;GNG5;GNB2;PRKCA;DLGAP1;SLC1A1;PPP3CC;GNG4

Shank2 has several biochemical functions, for example, SH3 domain binding, ionotropic glutamate receptor binding, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Shank2 itself. We selected most functions Shank2 had, and list some proteins which have the same functions with Shank2. You can find most of the proteins on our site.

Function	Related Protein
SH3 domain binding	MVB12A;PLSCR3;PTPN12;SIRPA;SH3BP1;SHANK2;CIT;RAD9A;SOS1
ionotropic glutamate receptor binding	CACNG2;DLG4;SHANK2;DLG4B;GNAS;DLG1L;DRD2;DLG1;SHANK3
protein C-terminus binding	YWHAB;VGLL3;SHANK2;PRDX3;NEIL1;RABAC1;PIAS3;BAIAP2;SIAH1

Shank2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Shank2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Shank2.

Grin1; Pde4d; Grin2b; Ywhab

Heo, JW; Kim, JH; et al. Inhibitory Activity of Bevacizumab to Differentiation of Retinoblastoma Cells. PLOS ONE 7:-(2012).

Raab, M; Boeckers, TM; et al. PROLINE-RICH SYNAPSE-ASSOCIATED PROTEIN-1 AND 2 (ProSAP1/Shank2 AND ProSAP2/Shank3)-SCAFFOLDING PROTEINS ARE ALSO PRESENT IN POSTSYNAPTIC SPECIALIZATIONS OF THE PERIPHERAL NERVOUS SYSTEM. NEUROSCIENCE 171:421-433(2010).

Synaptic Proteins