SLAMF7
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Official Full Name
SLAM family member 7
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Overview
SLAM family member 7 is a protein that in humans is encoded by the SLAMF7 gene. -
Synonyms
SLAMF7; SLAM family member 7; 19A; CD319; CRACC; CS1; 19A24 protein; CD 319; CD2 like receptor activating cytotoxic cells; CD2 subset 1; CD319 antigen; Membrane protein FOAP 12; Novel Ly9; Novel LY9 (lymphocyte antigen 9) like protein; Protein 19A; SLAMF 7; OTTHUMP00000025677; OTTHUMP00000025678; OTTHUMP00000025679; membrane protein FOAP-12; CD2-like receptor activating cytotoxic cells; CD2-like receptor-activating cytotoxic cells; novel LY9 (lymphocyte a;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Antibody
- Human
- Mouse
- Rhesus macaque
- Rhesus Macaque
- Rhesus monkey
- E.coli
- HEK293
- HEK293 cells
- HEK293T
- Human Cell
- Human cells
- In Vitro Cell Free System
- Insect Cell
- Mammalian cells
- Mouse
- Rabbit
- Wheat Germ
- Avi
- His
- C
- Fc
- hFc
- 6×His
- His(C
- ter)
- Flag
- GST
- hIgG1
- hIgG4
- His (Fc)
- Myc
- His|T7
- mFc
- Mouse|IgG2a|Fc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- SLAMF7 Related Articles
- SLAMF7 Related Research Area
SLAMF7 involved in several pathways and played different roles in them. We selected most pathways SLAMF7 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SLAMF7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
SLAMF7 has several biochemical functions, for example, chromatin DNA binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLAMF7 itself. We selected most functions SLAMF7 had, and list some proteins which have the same functions with SLAMF7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin DNA binding | SMAD3;BCL6;RXRA;HIST1H1B;VAX1;INSM1B;GRHL2;HIST1H1A;FOXC2 |
| protein binding | INPP4B;FDX1L;VEPH1;MPZL2B;ZMYM4;KTN1;DIS3;TIA1;CCT2 |
| sequence-specific DNA binding | HOXA3;HLX;RORA;GBX1;TLX3;ZNF35;GATA4;ZSCAN12;WT1 |
| transcription factor activity, sequence-specific DNA binding | ZNF583;ZNF436;HOXA6;RELA;ELF2B;NR1H4;PRDM1;POU3F4;ZNF548 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | MAFGA;BARHL1B;MAFB;FOXF1;CREBBP;PAX9;CSRNP2;TBX5;ATF1 |
SLAMF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLAMF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLAMF7.
MAK; CLK3; TRIB2
- Q&As
- Reviews
Q&As (6)
Ask a questionSLAMF7 protein is involved in regulating immune cell activation, proliferation, and transmission of background signals by binding to activating ligands, such as CD319, thereby influencing the immune response.
By combining with immunotherapy, such as anti-PD-1 antibodies, the immune response can be further enhanced and the anti-tumor effect can be improved. The study of SLAMF7 protein provides a new direction for the development of combinatorial therapeutic strategies.
This protein is mainly expressed in the immune system, including immune cells such as plasma cells, NK cells, and activated T cells.
The role of SLAMF7 protein in other types of cancer is unclear, and further research is needed to determine its potential role in other cancers.
Yes, the SLAMF7 protein has been shown to be a potential therapeutic target. A monoclonal antibody drug targeting SLAMF7 protein (Elotuzumab) has been developed for the treatment of multiple myeloma.
SLAMF7 protein interacts with NK cells in multiple myeloma and plays a role in inhibiting and controlling tumor growth by activating the anti-tumor activity of NK cells.
Customer Reviews (3)
Write a reviewIt has a high solubility and can be easily prepared at the desired concentration.
It was found to be well active and could effectively perform the required biological activity experiments.
It was observed that SLAMF7 had good crystallinity, which was conducive to crystallography research.
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