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SLC6A4

  • Official Full Name

    solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

  • Overview

    This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
  • Synonyms

    SLC6A4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; sodium-dependent serotonin transporter; 5HTT; 5HT transporter; solute carrier family 6 member 4; 5-hydroxytryptamine (serotonin) transporter; Sodium-dependent serotonin t;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLC6A4-2322H Recombinant Human SLC6A4 protein, GST-tagged Wheat Germ GST
Human SLC6A4-363H Recombinant Human SLC6A4 Mammalian Cell His
Human SLC6A4-2783H Recombinant Human SLC6A4, GST-tagged E.coli GST 1-71
Human SLC6A4-8938H Recombinant Human SLC6A4 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SLC6A4-8142H Recombinant Human SLC6A4 protein, His & GST-tagged E.coli His/GST Ala181~Ser252 (Accession # P31645)
Human SLC6A4-1638HCL Recombinant Human SLC6A4 cell lysate N/A
Human SLC6A4-1099H Recombinant Human SLC6A4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SLC6A4-601HFL Active Recombinant Full Length Human SLC6A4 Protein, C-Flag-tagged Mammalian cells Flag
Human SLC6A4-695HF Recombinant Full Length Human SLC6A4 Protein, GST-tagged In Vitro Cell Free System GST 630 amino acids
Human SLC6A4-2034H Recombinant Human SLC6A4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SLC6A4-6307H Recombinant Human SLC6A4 Protein (Ala181-Ser252), N-GST tagged E.coli N-GST Ala181-Ser252
Human SLC6A4-2034H-B Recombinant Human SLC6A4 Protein Pre-coupled Magnetic Beads HEK293
Mouse SLC6A4-15504M Recombinant Mouse SLC6A4 Protein Mammalian Cell His
Mouse Slc6a4-2079M Recombinant Mouse Slc6a4 Protein, His-tagged E.coli N-His Ser483-Val630
Mouse SLC6A4-8413M Recombinant Mouse SLC6A4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SLC6A4-8413M-B Recombinant Mouse SLC6A4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Slc6a4-1197M Recombinant Mouse Slc6a4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Cynomolgus Monkey SLC6A4-937C Recombinant Cynomolgus SLC6A4 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey SLC6A4-680C-B Recombinant Cynomolgus Monkey SLC6A4 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey SLC6A4-680C Recombinant Cynomolgus Monkey SLC6A4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SLC6A4-4306R Recombinant Rhesus monkey SLC6A4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SLC6A4-4122R Recombinant Rhesus Macaque SLC6A4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SLC6A4-4122R-B Recombinant Rhesus Macaque SLC6A4 Protein Pre-coupled Magnetic Beads HEK293
Chicken SLC6A4-7125C Recombinant Chicken SLC6A4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

SLC6A4 involved in several pathways and played different roles in them. We selected most pathways SLC6A4 participated on our site, such as Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC6A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Serotonergic synapsePLCB1;GNG7;CYP2C70;GNAI3;PLA2G4F;HTR4;KCNN2;SLC18A1;PRKCG

SLC6A4 has several biochemical functions, for example, Rab GTPase binding, actin filament binding, cocaine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC6A4 itself. We selected most functions SLC6A4 had, and list some proteins which have the same functions with SLC6A4. You can find most of the proteins on our site.

Function Related Protein
Rab GTPase bindingAP3M1;RIMS1;ATP6AP1;FER;ANXA2;TBC1D30;CCDC64;ALS2;TMEM127
actin filament bindingACTN2B;SHROOM3;CTNNA1;RCSD1;VPS16;MYH9;MACF1;NEBL;TMEM201
cocaine binding
monoamine transmembrane transporter activitySLC18A2;SLC22A1;SLC6A2;SLC18A1;SLC6A3;SLC29A4;SLC6A4
myosin bindingDMD;MYBPC3;KIRREL;ACTC1;ACTA1;CALD1;CALD1B;SLC6A4;STX4A
nitric-oxide synthase bindingDMD;SLC6A4;DNM3;CAV3;SNTA1;DNM2;ACTB;CALM3;SCN5A
protein bindingRIOK3;CUL4B;FOXP2;KIF1B;KLF12;TMPO;ADRM1;RPGRIP1;SPERT
protein homodimerization activityHSF2;CIDEA;CUBN;PRTFDC1;HELT;SIAH1A;TGFB2;BCL2L10;GIMAP7
serotonin transmembrane transporter activitySLC6A4;SLC18A1;SLC6A4A;SLC6A4B
serotonin:sodium symporter activity
syntaxin-1 bindingSNAP25A;CPLX1;STXBP1;STXBP3;SNAP25;VAMP3;NSF;STXBP2;SNAP25B

SLC6A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC6A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC6A4.

Gpm6b; imipramine; paroxetine; GPM6B; PICK1

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