SLPI
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Official Full Name
secretory leukocyte peptidase inhibitor
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Overview
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity. [provided by RefSeq, Jul 2008] -
Synonyms
SLPI; secretory leukocyte peptidase inhibitor; ALP; MPI; ALK1; BLPI; HUSI; WAP4; WFDC4; HUSI-I; antileukoproteinase; HUSI-1; protease inhibitor WAP4; mucus proteinase inhibitor; seminal proteinase inhibitor; WAP four-disulfide core domain protein 4; secretory leukocyte protease inhibitor (antileukoproteinase);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- GST
- Involved Pathway
- Protein Function
- Interacting Protein
- SLPI Related Articles
- SLPI Related Research Area
SLPI involved in several pathways and played different roles in them. We selected most pathways SLPI participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SLPI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
SLPI has several biochemical functions, for example, endopeptidase inhibitor activity, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLPI itself. We selected most functions SLPI had, and list some proteins which have the same functions with SLPI. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase inhibitor activity | RECK;STFA1;C3B.2;PCSK1N;CST14B.1;Serpina1c;PROS1;C4A;USP14 |
| enzyme binding | TSPYL1;KRT79;NOP14;CAT;JUND;LUC7L2;EIF4E;SCARB2;SUPT5H |
| protein binding | SNX31;ALDH18A1;SWSAP1;RBMY1A1;PTGIS;TRAM2;IFITM1;CARD9;MGST1 |
| serine-type endopeptidase inhibitor activity | SERPINA1E;SPINT1A;SERPINA10;HRG;A2M;SERPINA11;SPOCK1;ITIH5;APPB |
SLPI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLPI here. Most of them are supplied by our site. Hope this information will be useful for your research of SLPI.
SGTA; FAM9B; ELANE; NFKBIB; MAPK8IP2
- Q&As
- Reviews
Q&As (5)
Ask a questionThe potential side effects of SLPI supplementation or therapy have not been extensively studied and would require further investigation.
Several clinical trials have investigated the use of SLPI in conditions such as chronic obstructive pulmonary disease (COPD) and inflammatory bowel disease (IBD).
SLPI levels in biological fluids, such as saliva and sputum, have been studied as potential biomarkers for various diseases and conditions.
SLPI has anti-inflammatory properties and can inhibit the activity of various proteases involved in the inflammatory response.
SLPI has been investigated as a potential therapeutic agent for HIV/AIDS, as it may inhibit viral replication and transmission.
Customer Reviews (3)
Write a reviewthe SLPI protein is highly regarded for its excellent performance in WB assays and its significant contribution to protein EM structure analysis.
The SLPI protein is highly recommended for researchers conducting protein studies, especially in Western blotting (WB) experiments.
Its reliability and high quality make it a valuable tool in various applications, ranging from enzymatic assays to studying protein-protein interactions.
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