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SNCA

  • Official Full Name

    synuclein, alpha (non A4 component of amyloid precursor)

  • Overview

    Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
  • Synonyms

    SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Ateles geoffroyi (Black-handed spider monkey)
  • Chicken
  • Cynomolgus
  • Cynomolgus monkey
  • Erythrocebus patas (Red guenon) (Cercopithecus patas)
  • Human
  • Monkey
  • Mouse
  • Pan paniscus (Pygmy chimpanzee) (Bonobo)
  • Pig
  • Pongo abelii (Sumatran orangutan)
  • Rat
  • Saguinus labiatus (Red-chested mustached tamarin)
  • E. coli
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Human
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • His
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • SUMO
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SNCA-240H Active Recombinant Human SNCA protein E.coli N/A
Human SNCA-2874H Active Recombinant Human SNCA protein, Fc-tagged HEK293 Fc Met 1-Ala 140
Human SNCA-01H Active Recombinant Human SNCA Protein E.coli
Human SNCA-7034H Recombinant Human SNCA, None tagged E.coli N/A
Human SNCA-385H Recombinant Human SNCA Protein E.coli N/A 1-140 aa
Human SNCA-27344TH Recombinant Human SNCA E.coli N/A
Human SNCA-27343TH Recombinant Human SNCA E.coli N/A
Human SNCA-6937H Recombinant Human Synuclein, Alpha (non A4 component of amyloid precursor) E.coli N/A
Human SNCA-75H Recombinant Human SNCA, 112aa E.coli N/A
Human SNCA-27348TH Recombinant Human SNCA E.coli N/A
Human SNCA-27338TH Recombinant Human SNCA, His-tagged E.coli His
Human SNCA-78H Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor) E.coli N/A
Human SNCA-76H Recombinant Human SNCA, A30P Mutant E.coli N/A
Human SNCA-2837H Recombinant Human SNCA, GST-tagged E.coli GST 1-140aa
Human SNCA-245H Recombinant Human SNCA, His-tagged E.coli His
Human SNCA-5126H Recombinant Human Synuclein, Alpha (Non A4 Component Of Amyloid Precursor) Human N/A
Human SNCA-77H Recombinant Human SNCA, A53T Mutant E.coli N/A
Human SNCA-293H Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), 1-60 E.coli N/A
Human SNCA-5125H Recombinant Human Synuclein, Alpha (Non A4 Component Of Amyloid Precursor) Human N/A
Human SNCA-5124H Recombinant Human Synuclein, Alpha (Non A4 Component Of Amyloid Precursor) Human N/A
Human SNCA-290H Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), A30P/A53T E.coli N/A
Human SNCA-292H Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), 96-140 E.coli N/A
Human SNCA-295H Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), 1-95 E.coli N/A
Human SNCA-237H Recombinant Human SNCA protein E.coli N/A amino acids 96-140
Human SNCA-291H Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), Delta-NAC E.coli N/A
Human SNCA-234H Recombinant Human SNCA protein E.coli N/A amino acids 1-60
Human SNCA-235H Recombinant Human SNCA protein E.coli N/A amino acids 1-95
Human SNCA-294H Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), E46K E.coli N/A
Human SNCA-1634HCL Recombinant Human SNCA 293 Cell Lysate HEK293 N/A
Human SNCA-166H Recombinant Human SNCA protein, His-tagged E.coli His Met1-Ala140
Human SNCA-27339TH Native Human SNCA E.coli N/A
Human SNCA-2710H Recombinant Human SNCA Protein, His-tagged E.coli N-His Met1-Ala140
Human SNCA-3509H Recombinant Human SNCA protein, GST-tagged E.coli GST 1-139AA
Human SNCA-5522H Recombinant Human SNCA protein, His-tagged Yeast His 1-140aa
Human SNCA-27342TH Native Human SNCA E.coli N/A
Human SNCA-112H Recombinant Human SNCA Protein E.coli
Human SNCA-60H Recombinant Human SNCA Protein E.coli
Human SNCA-2055H Recombinant Human SNCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SNCA-02H Recombinant Human SNCA Protein E.coli
Human SNCA-27341TH Native Human SNCA E.coli N/A
Human SNCA-326HFL Recombinant Full Length Human SNCA Protein, C-Flag-tagged Mammalian cells Flag
Human SNCA-2055H-B Recombinant Human SNCA Protein Pre-coupled Magnetic Beads HEK293
Human SNCA-2058H Recombinant Human SNCA Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SNCA-27345TH Native Human SNCA E.coli N/A
Human SNCA-2744H Recombinant Human SNCA protein(11-110 aa), C-His-tagged E. coli C-His 11-110 aa
Human SNCA-2393H Recombinant Human SNCA Protein (Met1-Ala140), His tagged E.coli His Met1-Ala140
Human SNCA-5970H Recombinant Human SNCA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SNCA-6456H Recombinant Human SNCA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SNCA-2875H Recombinant Human SNCA protein, His-Avi-tagged, Biotinylated E.coli His-Avi Met 1-Ala 140
Mouse Snca-5826M Active Recombinant Mouse Snca protein, His-tagged E.coli His Met 1 - Ala 140
Mouse Snca-2730M Recombinant Mouse Synuclein, Alpha E.coli N/A
Mouse SNCA-15673M Recombinant Mouse SNCA Protein Mammalian Cell His
Mouse Snca-386M Recombinant Mouse Snca Protein E.coli N/A 1-140 aa
Mouse SNCA-8524M Recombinant Mouse SNCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SNCA-8524M-B Recombinant Mouse SNCA Protein Pre-coupled Magnetic Beads HEK293
Mouse Snca-5996M Recombinant Mouse Snca Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Snca-7340M Recombinant Mouse Snca Protein E.coli 1-140
Rat SNCA-5638R Recombinant Rat SNCA Protein Mammalian Cell His
Rat Snca-387R Recombinant Rat Snca Protein E.coli N/A 1-140 aa
Rat Snca-5827R Recombinant Rat Snca protein, His-tagged E.coli His Lys23~Ala140 (Accession # P37377)
Rat Snca-1372R Recombinant Rat Snca Protein, GST-tagged E.coli GST
Rat SNCA-5297R-B Recombinant Rat SNCA Protein Pre-coupled Magnetic Beads HEK293
Rat SNCA-5297R Recombinant Rat SNCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Monkey SNCA-3392L Recombinant Lagothrix lagotricha (Common woolly monkey) SNCA, His-tagged E.Coli or Yeast His 140
Ateles geoffroyi (Black-handed spider monkey) SNCA-3391A Recombinant Ateles geoffroyi (Black-handed spider monkey) SNCA, His-tagged E.Coli or Yeast His 140
Cynomolgus Snca-1890C Active Recombinant Cynomolgus Snca protein, His-tagged E.coli His Met 1 - Ala 140
Cynomolgus monkey SNCA-3389M Recombinant Cynomolgus monkey SNCA protein, His-SUMO-tagged E.coli His-SUMO 1-140aa
Cynomolgus monkey SNCA-5523C Recombinant Cynomolgus monkey SNCA protein, His-tagged Yeast His 1-140aa
Erythrocebus patas (Red guenon) (Cercopithecus patas) SNCA-3393E Recombinant Erythrocebus patas (Red guenon) (Cercopithecus patas) SNCA, His-tagged E.Coli or Yeast His 140
Pan paniscus (Pygmy chimpanzee) (Bonobo) SNCA-3394P Recombinant Pan paniscus (Pygmy chimpanzee) (Bonobo) SNCA, His-tagged E.Coli or Yeast His 140
Pongo abelii (Sumatran orangutan) SNCA-3390S Recombinant Sumatran orangutan SNCA, His-tagged E.Coli or Yeast His 140
Saguinus labiatus (Red-chested mustached tamarin) SNCA-3395S Recombinant Saguinus labiatus (Red-chested mustached tamarin) SNCA, His-tagged E.Coli or Yeast His 140
Pig SNCA-5869P Recombinant Pig SNCA protein E.coli N/A 1-140aa
Pig SNCA-4475P Recombinant Pig SNCA protein, His-tagged E.coli His 1-140aa
Pig SNCA-4474P Recombinant Pig SNCA protein, His&Myc-tagged E.coli His&Myc 1-140aa
Chicken SNCA-6239C Recombinant Chicken SNCA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SNCA Related Articles
  • SNCA Related Research Area

SNCA involved in several pathways and played different roles in them. We selected most pathways SNCA participated on our site, such as Alzheimers disease, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alzheimers diseaseFADD;PPP3R1;COX7A1;APBB1;COX7B;NDUFS4;NDUFS5;SDHC;PLCB1
Parkinsons diseaseNDUFS1;VDAC3;UQCRFS1;NDUFV2;NDUFB2;NDUFB10;COX7A2;UBE2J1;SNCAIP

SNCA has several biochemical functions, for example, alpha-tubulin binding, beta-tubulin binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNCA itself. We selected most functions SNCA had, and list some proteins which have the same functions with SNCA. You can find most of the proteins on our site.

Function Related Protein
alpha-tubulin bindingTRPV4;WASH;ARL4C;CAV3;C9orf24;DDL-2;INO80;WASH1;PPARGC1A
beta-tubulin bindingSERPINB1A;TBCD;VAPB;AKAP1;PIFO;ADNP;TRPV4;BBS4;FGF13
calcium ion bindingPCDHA5;GUCA1A;CDH13;CIB3;FLG2;CRACR2B;EHD2;PCDH2G17;THBS2
copper ion bindingCUTC;LOXL4;PRNPA;HEPH;S100V2;MT1;P2RX2;PAM;CCC2
cysteine-type endopeptidase inhibitor activity involved in apoptotic processPRDX3;RPS6KA1;GAS6;TFAP2B;IGF1RA;PRDX5;VIL1;RPS6KA3;BIRC7
dynein bindingSNCA;DCTN6;SERPINB1A;ATMIN;SMC3;KATNB1;DCTN1;NEFH;PAFAH1B1B
NOT fatty acid bindingSNCA;SERPINB1A
ferrous iron bindingFTO;SERPINB1A;NT5E;ALKBH1;TRR1;Trf;ALKBH2;TF;ALKBH3
histone bindingNASP;HIST1H3C;CHD2;PRKCBP1L;SMARCA2;NPM1;HAT1;WDTC1;SET
identical protein bindingSTAT6;ORAI1;RUVBL2;AHCY;CLDN10;APP;SIAH1A;SNX16;DYNLT1
kinesin bindingKCNC1;NEFH;KIAA1279;MAPK8IP2;CD36;KIFAP3A;NUP62;PRC1;KIFAP3B
magnesium ion bindingSTK11;ALPI;MAPK12;ATP9A;ATP9B;FIGNL1;THTPA;MTHFD2;TDP2
microtubule bindingPRC1A;NEFM;RAE1;MTAP1A;FMR1;TUBGCP5;EML1;NUMA1;PRC1
oxidoreductase activityFAM84B;RDH13;DHRS13A.3;DHRS3B;AOX4;CYP1C2;ALDH9A1A.1;CYP3C4;SOD3A
NOT phospholipase D inhibitor activitySNCA;SERPINB1A
phospholipase bindingPla2r1;CALM3;PTPN11;CALM;APOC2;PARK2;SERPINB1A;PRKCZ;LMNB1
phospholipid bindingAPOA2;GOT2;MYOF;GRK5;PAFAH2;SPTB;F10;PLA2G2A;SPTBN1
phosphoprotein bindingPKD2;CBX4;DPYSL3;TBL2;RB1;LYN;MID1;PITX2;FKBP4
protein N-terminus bindingSTX5;SUV39H1;NCOR2;ARF6;NIPBL;APTX;NCOA3;TRP53;KCNB1
protein bindingKIF3B;DSC2;KCNJ15;HSPH1;SEC63;PCBP1;PITX2;PDCD6;MTMR6
protein domain specific bindingRXRA;MED12;STX1B;PRKCI;DDX6;YWHAQB;FOXA2;RAP2B;YWHABA
tau protein bindingPPP2R2A;S100B;APOE;AATF;HDAC6;SNCA;DYRK1A;FKBP4;SERPINB1A
transcription regulatory region DNA bindingTP53;XRCC6;TOMM20A;IKZF1;TAF7L;JUN;SMAD6;TBX16;ATF5
zinc ion bindingLTA4H;MT1E;PPARA;TRIM35-23;G2E3;TCEA3;LIMCH1B;NR4A1;MT1M

SNCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNCA here. Most of them are supplied by our site. Hope this information will be useful for your research of SNCA.

Alvarez-Castelao, B; Gorostidi, A; et al. Epitope mapping of antibodies to alpha-synuclein in LRRK2 mutation carriers, idiopathic Parkinson disease patients, and healthy controls. FRONTIERS IN AGING NEUROSCIENCE 6:-(2014).
Daher, JPL; Volpicelli-Daley, LA; et al. Abrogation of alpha-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:9289-9294(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can SNCA protein levels in cerebrospinal fluid be used as a diagnostic marker for Parkinson's disease? 10/11/2022

Yes, elevated levels of SNCA protein in cerebrospinal fluid can be indicative of Parkinson's disease.

What potential therapeutic strategies target SNCA protein for Parkinson's disease treatment? 03/27/2022

Therapies may include reducing SNCA aggregation or preventing its misfolding.

Are there any genetic mutations related to SNCA protein that increase the risk of Parkinson's disease? 10/17/2018

Yes, certain mutations in the SNCA gene are associated with familial Parkinson's disease.

How is SNCA protein associated with neurodegenerative diseases? 06/11/2016

Aggregates of misfolded SNCA protein are implicated in various neurodegenerative diseases, including Parkinson's disease.

Are there any ongoing clinical trials investigating SNCA-related therapies? 05/27/2016

Yes, several clinical trials are exploring treatments targeting SNCA protein in Parkinson's disease.

Customer Reviews (3)

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Reviews
08/31/2020

    Its integrity and reliability make it an ideal choice to address the specific objectives of my research.

    03/12/2020

      Their profound knowledge and expertise will undoubtedly help me overcome any challenges that arise, and their prompt assistance ensures a seamless progression of my research.

      10/16/2017

        In addition to the exceptional quality of the protein, the manufacturer's support extends beyond the product itself.

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