SNCA
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Official Full Name
synuclein, alpha (non A4 component of amyloid precursor)
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Overview
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009] -
Synonyms
SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Ateles geoffroyi (Black-handed spider monkey)
- Chicken
- Cynomolgus
- Cynomolgus monkey
- Erythrocebus patas (Red guenon) (Cercopithecus patas)
- Human
- Monkey
- Mouse
- Pan paniscus (Pygmy chimpanzee) (Bonobo)
- Pig
- Pongo abelii (Sumatran orangutan)
- Rat
- Saguinus labiatus (Red-chested mustached tamarin)
- E. coli
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- Human
- Mammalian Cell
- Mammalian cells
- Yeast
- C
- His
- Fc
- Flag
- GST
- His (Fc)
- Avi
- Myc
- SUMO
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- SNCA Related Articles
- SNCA Related Research Area
SNCA involved in several pathways and played different roles in them. We selected most pathways SNCA participated on our site, such as Alzheimers disease, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Alzheimers disease | FADD;PPP3R1;COX7A1;APBB1;COX7B;NDUFS4;NDUFS5;SDHC;PLCB1 |
Parkinsons disease | NDUFS1;VDAC3;UQCRFS1;NDUFV2;NDUFB2;NDUFB10;COX7A2;UBE2J1;SNCAIP |
SNCA has several biochemical functions, for example, alpha-tubulin binding, beta-tubulin binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNCA itself. We selected most functions SNCA had, and list some proteins which have the same functions with SNCA. You can find most of the proteins on our site.
Function | Related Protein |
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alpha-tubulin binding | TRPV4;WASH;ARL4C;CAV3;C9orf24;DDL-2;INO80;WASH1;PPARGC1A |
beta-tubulin binding | SERPINB1A;TBCD;VAPB;AKAP1;PIFO;ADNP;TRPV4;BBS4;FGF13 |
calcium ion binding | PCDHA5;GUCA1A;CDH13;CIB3;FLG2;CRACR2B;EHD2;PCDH2G17;THBS2 |
copper ion binding | CUTC;LOXL4;PRNPA;HEPH;S100V2;MT1;P2RX2;PAM;CCC2 |
cysteine-type endopeptidase inhibitor activity involved in apoptotic process | PRDX3;RPS6KA1;GAS6;TFAP2B;IGF1RA;PRDX5;VIL1;RPS6KA3;BIRC7 |
dynein binding | SNCA;DCTN6;SERPINB1A;ATMIN;SMC3;KATNB1;DCTN1;NEFH;PAFAH1B1B |
NOT fatty acid binding | SNCA;SERPINB1A |
ferrous iron binding | FTO;SERPINB1A;NT5E;ALKBH1;TRR1;Trf;ALKBH2;TF;ALKBH3 |
histone binding | NASP;HIST1H3C;CHD2;PRKCBP1L;SMARCA2;NPM1;HAT1;WDTC1;SET |
identical protein binding | STAT6;ORAI1;RUVBL2;AHCY;CLDN10;APP;SIAH1A;SNX16;DYNLT1 |
kinesin binding | KCNC1;NEFH;KIAA1279;MAPK8IP2;CD36;KIFAP3A;NUP62;PRC1;KIFAP3B |
magnesium ion binding | STK11;ALPI;MAPK12;ATP9A;ATP9B;FIGNL1;THTPA;MTHFD2;TDP2 |
microtubule binding | PRC1A;NEFM;RAE1;MTAP1A;FMR1;TUBGCP5;EML1;NUMA1;PRC1 |
oxidoreductase activity | FAM84B;RDH13;DHRS13A.3;DHRS3B;AOX4;CYP1C2;ALDH9A1A.1;CYP3C4;SOD3A |
NOT phospholipase D inhibitor activity | SNCA;SERPINB1A |
phospholipase binding | Pla2r1;CALM3;PTPN11;CALM;APOC2;PARK2;SERPINB1A;PRKCZ;LMNB1 |
phospholipid binding | APOA2;GOT2;MYOF;GRK5;PAFAH2;SPTB;F10;PLA2G2A;SPTBN1 |
phosphoprotein binding | PKD2;CBX4;DPYSL3;TBL2;RB1;LYN;MID1;PITX2;FKBP4 |
protein N-terminus binding | STX5;SUV39H1;NCOR2;ARF6;NIPBL;APTX;NCOA3;TRP53;KCNB1 |
protein binding | KIF3B;DSC2;KCNJ15;HSPH1;SEC63;PCBP1;PITX2;PDCD6;MTMR6 |
protein domain specific binding | RXRA;MED12;STX1B;PRKCI;DDX6;YWHAQB;FOXA2;RAP2B;YWHABA |
tau protein binding | PPP2R2A;S100B;APOE;AATF;HDAC6;SNCA;DYRK1A;FKBP4;SERPINB1A |
transcription regulatory region DNA binding | TP53;XRCC6;TOMM20A;IKZF1;TAF7L;JUN;SMAD6;TBX16;ATF5 |
zinc ion binding | LTA4H;MT1E;PPARA;TRIM35-23;G2E3;TCEA3;LIMCH1B;NR4A1;MT1M |
SNCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNCA here. Most of them are supplied by our site. Hope this information will be useful for your research of SNCA.
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, elevated levels of SNCA protein in cerebrospinal fluid can be indicative of Parkinson's disease.
Therapies may include reducing SNCA aggregation or preventing its misfolding.
Yes, certain mutations in the SNCA gene are associated with familial Parkinson's disease.
Aggregates of misfolded SNCA protein are implicated in various neurodegenerative diseases, including Parkinson's disease.
Yes, several clinical trials are exploring treatments targeting SNCA protein in Parkinson's disease.
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