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SRSF10

  • Official Full Name

    serine/arginine-rich splicing factor 10

  • Overview

    This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. This gene has multiple pseudogenes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.
  • Synonyms

    NSSR; TASR; SRp38; TASR1; TASR2; FUSIP1; FUSIP2; SFRS13; SRrp40; SFRS13A; FLJ30749; FLJ43846; DKFZp686H0644; serine/arginine-rich splicing factor 10; OTTHUMP00000015773; OTTHUMP00000015774; OTTHUMP00000015775; OTTHUMP00000015776; OTTHUMP00000015777; OTTHUMP00000015778; SR splicing factor 10; splicing factor SRp38; TLS-associated SR protein; neural-salient SR protein; 40 kDa SR-repressor protein; TLS-associated protein TASR; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein 1; TLS-associated serine-arginine protein 2; splicing factor, arginine/serine-rich 13; splicing factor, arginine/serine-rich 13A; serine-arginine repressor protein (40 kDa); TLS-associated protein with Ser-Arg repeats; FUS-interacting serine-arginine-rich protein 1; FUS interacting protein (serine-arginine rich) 1; FUS-interacting protein (serine-arginine rich) 2; serine/arginine-rich splicing factor 10; SRSF10;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SRSF10-1906HCL Recombinant Human SFRS13A 293 Cell Lysate HEK293 N/A
Human SRSF10-990H Recombinant Human SRSF10 Protein (1-183 aa), His-SUMO-tagged E.coli His/SUMO 1-183 aa
Human SRSF10-995H Recombinant Human SRSF10 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human SRSF10-3170H Recombinant Human SRSF10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SRSF10-4556H Recombinant Human SRSF10 Protein, GST-tagged Wheat Germ GST
Mouse SRSF10-16009M Recombinant Mouse SRSF10 Protein Mammalian Cell His
Mouse SRSF10-8735M Recombinant Mouse SRSF10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SRSF10-8735M-B Recombinant Mouse SRSF10 Protein Pre-coupled Magnetic Beads HEK293
Mouse Srsf10-1021M Recombinant Mouse Srsf10 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque SRSF10-4474R Recombinant Rhesus monkey SRSF10 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SRSF10-4290R Recombinant Rhesus Macaque SRSF10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SRSF10-4290R-B Recombinant Rhesus Macaque SRSF10 Protein Pre-coupled Magnetic Beads HEK293
Chicken SRSF10-2595C Recombinant Chicken SRSF10 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

SRSF10 involved in several pathways and played different roles in them. We selected most pathways SRSF10 participated on our site, such as Spliceosome, mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRSF10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
SpliceosomeDDX42;HNRPKL;U2AF2B;RBM22;AQR;CTNNBL1;HSPA1B;HSPA1A;SF3B14
mRNA processingSRSF10;SF3B4;ADAM5;CLASRP;SNRPN;ZFP830;BICC1;RBM39;RAVER1

SRSF10 has several biochemical functions, for example, RNA binding, RS domain binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SRSF10 itself. We selected most functions SRSF10 had, and list some proteins which have the same functions with SRSF10. You can find most of the proteins on our site.

Function Related Protein
RNA bindingHNRNPH3;EIF4G2A;FUS;CLUHA;CAPRIN1;ADAD1;IFIT11;RBM5;CNOT7
RS domain bindingSRSF1;SRSF12;SRSF10;LUC7L;SRSF5
nucleotide bindingDIRAS1B;ABCD3A;ERBB3B;RBMS2;VMHCL;RALYL;GLULB;ACTC1B;PFKMA
poly(A) RNA bindingMYEF2;RRS1;PRAC;NXF3;RPS19;FAM103A1;ZNF385A;HNRNPUL1;MTERF
protein bindingFANCM;UBL5;MAP3K4;RELB;RPS3;ITGB1BP1;NCS1;NLRX1;ZNF133
unfolded protein bindingCALRL2;DNAJA3;UGGT1;TOMM20;CCT6A;TUBB4B;MKKS;H2-KE2;HSPA2

SRSF10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRSF10 here. Most of them are supplied by our site. Hope this information will be useful for your research of SRSF10.

YWHAG; SRPK2; SRPK1; YWHAQ; YWHAB; SFN; FUS; TRA2B; SRSF1; SRSF4; GABARAP; EIF4A3; GABARAPL2; MAGOH; GRB2; MZT1; MAP1LC3A; Srek1; SLAIN2

  • Q&As
  • Reviews

Q&As (5)

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What are the implications of SRSF10 protein in cardiovascular diseases? 05/31/2021

SRSF10 protein has been linked to alternative splicing events in genes associated with cardiovascular diseases, indicating its potential relevance in this area.

What tools are used to study the clinical application of SRSF10 protein? 12/10/2019

Techniques such as RNA sequencing, CRISPR/Cas9 gene editing, and antibody-based assays are used to study the role of SRSF10 protein in clinical applications.

How is the expression of SRSF10 protein regulated in cells? 07/05/2018

The expression of SRSF10 protein is regulated by various mechanisms, including transcriptional control, post-transcriptional modifications, and protein stability.

How does SRSF10 protein impact RNA splicing? 04/26/2016

SRSF10 protein modulates alternative splicing by binding to specific RNA sequences and influencing the inclusion or exclusion of particular exons in mRNA transcripts.

Can SRSF10 protein be targeted for personalized medicine? 01/04/2016

Understanding the role of SRSF10 protein in specific disease contexts may lead to the development of personalized therapeutic approaches targeting this protein.

Customer Reviews (3)

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Reviews
05/25/2022

    the SRSF10 Protein's applicability in protein electron microscopy structure analysis is remarkable.

    02/09/2019

      This protein has consistently demonstrated outstanding results, making it an indispensable tool in my research endeavors.

      06/03/2017

        In WB experiments, the SRSF10 Protein consistently delivers exceptional performance.

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