tab3
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  • Official Full Name
  • TGF-beta activated kinase 1/MAP3K7 binding protein 3
  • Background
  • The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
  • Synonyms
  • TAB3; TGF-beta activated kinase 1/MAP3K7 binding protein 3; MAP3K7IP3, mitogen activated protein kinase kinase kinase 7 interacting protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TAK1 binding protein 3; TAB-3; TAK1-binding protein 3
Cat.#:TAB3-4149ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TAB3
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Involved Pathway

TAB3 involved in several pathways and played different roles in them. We selected most pathways TAB3 participated on our site, such as NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAB3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NOD-like receptor signaling pathway
NAIP6; MAPK8A; CARD9; NFKBIB; IL6; CASPA; HSP90AA1; CCL2; PYDC1; BIRC3

Protein Function

TAB3 has several biochemical functions, for example, kinase activity, transferase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAB3 itself. We selected most functions TAB3 had, and list some proteins which have the same functions with TAB3. You can find most of the proteins on our site.
Function
Related Protein
Function kinase activity
Related Protein BMPR2A; BCR; ALPK2; JAK2A; PFKMB; PDXKB; ZNF143B; ANKK1; SRPK1A; DYRK1AA
Function transferase activity
Related Protein ERBB3B; BMPR2B; PRDM13; OAS1B; PKN1B; UAP1L1; NEK5; DCLK1A; FUT9A; PTAR1
Function zinc ion binding
Related Protein ABLIM1A; S100A8; MAN2A2; LHX2B; CBLC; MEX3C; NEIL2; TRIM101; ZDHHC19; EHMT1A

TAB3 Related Articles

Wang, J; Li, BX; et al. Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system. NATURE IMMUNOLOGY 16:237-U189(2015).
Lei, XB; Han, N; et al. Enterovirus 71 3C Inhibits Cytokine Expression through Cleavage of the TAK1/TAB1/TAB2/TAB3 Complex. JOURNAL OF VIROLOGY 88:9830-9841(2014).