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TACR1

  • Official Full Name

    TACR1 tachykinin receptor 1

  • Overview

    This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P.
  • Synonyms

    TACR1; tachykinin receptor 1; TAC1R; substance-P receptor; NK1R; NKIR; SPR; NK-1R; NK-1 receptor; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor);

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Cavia porcellus (Guinea pig)
  • Chicken
  • Human
  • Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)
  • Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Flag
  • 10His
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • C
  • 10×His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TACR1-1283HCL Recombinant Human TACR1 293 Cell Lysate HEK293 N/A
Human TACR1-16H Recombinant Human TACR1-3C Protein (M1-S226, H237-E335, E78N, Y121W, T222R), N-Flag and C-10×His-tagged Insect Cell N-Flag and C-10×His M1-S226, H237-E335, E78N, Y121W, T222R
Human TACR1-2748H Recombinant Human TACR1 Protein, His-tagged E.coli N-His Cys307-Ser407
Human TACR1-128H Recombinant Human TACR1 protein, GST-tagged E.coli GST 1-29 aa
Human TACR1-1267H Recombinant Human TACR1 Protein (M1-S226, H237-E335, E78N, Y121W, T222R), Flag-10×His tagged Insect Cell Flag-10His M1-S226, H237-E335, E78N, Y121W, T222R
Human TACR1-1155HFL Recombinant Human TACR1 protein, His&Flag-tagged HEK293 His&Flag 1-407 aa
Mouse TACR1-16376M Recombinant Mouse TACR1 Protein Mammalian Cell His
Mouse TACR1-8957M Recombinant Mouse TACR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TACR1-8957M-B Recombinant Mouse TACR1 Protein Pre-coupled Magnetic Beads HEK293
Rat TACR1-5906R Recombinant Rat TACR1 Protein Mammalian Cell His
Rat TACR1-5565R Recombinant Rat TACR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TACR1-5565R-B Recombinant Rat TACR1 Protein Pre-coupled Magnetic Beads HEK293
Canis lupus familiaris (Dog) (Canis familiaris) RFL6005CF Recombinant Full Length Dog Substance-P Receptor(Tacr1) Protein, His-Tagged E.coli expression system His Full Length (1-407)
Cavia porcellus (Guinea pig) RFL8485CF Recombinant Full Length Guinea Pig Substance-P Receptor(Tacr1) Protein, His-Tagged E.coli expression system His Full Length (1-407)
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) RFL11228LF Recombinant Full Length Lithobates Catesbeiana Substance-P Receptor(Tacr1) Protein, His-Tagged E.coli expression system His Full Length (1-408)
Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) RFL1186MF Recombinant Full Length Meriones Unguiculatus Substance-P Receptor(Tacr1) Protein, His-Tagged E.coli expression system His Full Length (1-407)
Mus musculus (Mouse) RFL16166MF Recombinant Full Length Mouse Substance-P Receptor(Tacr1) Protein, His-Tagged E.coli expression system His Full Length (1-407)
Rattus norvegicus (Rat) RFL32529RF Recombinant Full Length Rat Substance-P Receptor(Tacr1) Protein, His-Tagged E.coli expression system His Full Length (1-407)
Rhesus Macaque TACR1-4601R Recombinant Rhesus monkey TACR1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TACR1-4417R Recombinant Rhesus Macaque TACR1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TACR1-4417R-B Recombinant Rhesus Macaque TACR1 Protein Pre-coupled Magnetic Beads HEK293
Chicken TACR1-6431C Recombinant Chicken TACR1 Mammalian Cell His
Kit-1531 TACR1 CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-0953 TR-FRET Glucocorticoid Receptor Competitive Binding Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TACR1 Related Research Area

TACR1 involved in several pathways and played different roles in them. We selected most pathways TACR1 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with TACR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayHTR2CL1;PHKG2;GNAS;STIM1A;PTK2B;PLCB2;CYSLTR2;SLC8A4A;CAMK2D
Neuroactive ligand-receptor interactionTAAR13D;P2RX6;GHRHRL;VIPR2;CGNRH-R;GZMA;CHRNA2A;MTNR1A;NPY7R
MeaslesNFKBIA;IFNA14;TYK2;PIK3CB;TP53;EIF2AK2;IRAK1;IFNB1;OAS1

TACR1 has several biochemical functions, for example, protein binding, substance P receptor activity, tachykinin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TACR1 itself. We selected most functions TACR1 had, and list some proteins which have the same functions with TACR1. You can find most of the proteins on our site.

Function Related Protein
protein bindingTMEM218;CDPF1;CAND1;S1PR3;KIR2DL1;ATP1A2;MAPKAPK2;SNAP29;FCHSD2
substance P receptor activityTACR1A;TACR1
tachykinin receptor activityTACR3L;TACR1;TACR1B;TACR2;TACR1A;TACR3;TACR3A

TACR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TACR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TACR1.

TAC1

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Is TACR1 protein a potential target for personalized pain management? 04/30/2021

Yes, understanding individual variations in TACR1 protein may lead to personalized approaches for pain management.

In what conditions is TACR1 protein dysregulation implicated? 09/14/2020

Dysregulation of TACR1 protein is implicated in chronic pain conditions such as fibromyalgia, migraine, and neuropathic pain.

Are there any current drugs that target TACR1 protein? 03/23/2020

Yes, drugs targeting TACR1 protein, such as NK1 receptor antagonists, are being investigated for their potential in managing pain.

Can genetic variations in TACR1 protein influence pain sensitivity? 01/06/2019

Yes, genetic variations in TACR1 protein have been associated with differences in pain sensitivity and susceptibility to chronic pain conditions.

Are there any side effects associated with targeting TACR1 protein for pain management? 05/19/2016

Side effects of targeting TACR1 protein may include nausea, vomiting, and potential effects on mood and emotional state.

Customer Reviews (3)

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Reviews
04/01/2022

    This level of support instills trust and confidence in the product, facilitating smooth and successful experimentation.

    04/23/2020

      The TACR1 protein comes highly recommended for a variety of research applications.

      08/12/2019

        Its exceptional performance in ELISA assays makes it a reliable tool for detecting and quantifying specific target molecules with high sensitivity and specificity.

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