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TAPBP

Official Full Name

TAP binding protein (tapasin)
Overview

This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.
Synonyms

TAPBP; TAP binding protein (tapasin); tapasin; TAPA; NGS 17; NGS-17; NGS17; TAP associated protein; TAP binding protein; TAP BP; TAP-associated protein; TAP-binding protein; TPN; TPSN; TPSN_HUMAN;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Gallus gallus (Chicken)
Homo sapiens (Human)
Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli expression system
HEK293
HEK293T
Mammalian Cell
Wheat Germ

Tag

C
Myc
DDK
His
His (Fc)
Avi
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TAPBP-31499TH	Recombinant Human TAPBP	Wheat Germ	N/A	104 amino acids	Inquiry
Human	TAPBP-688H	Recombinant Human TAPBP Protein, His-tagged	HEK293	His		Inquiry
Human	TAPBP-122H	Recombinant Human TAPBP Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	TAPBP-154H	Recombinant Human TAPBP Protein, MYC/DDK-tagged, C13 and N15-labeled	HEK293	C-Myc/DDK		Inquiry
Mouse	Tapbp-6292M	Recombinant Mouse Tapbp Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Gallus gallus (Chicken)	RFL5354GF	Recombinant Full Length Chicken Tapasin(Tapbp) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (16-430)	Inquiry
Homo sapiens (Human)	RFL4366HF	Recombinant Full Length Human Tapasin(Tapbp) Protein, His-Tagged	E.coli expression system	His	Full Length (21-448)	Inquiry
Rhesus Macaque	TAPBP-4616R	Recombinant Rhesus monkey TAPBP Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	TAPBP-4432R	Recombinant Rhesus Macaque TAPBP Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	TAPBP-4432R-B	Recombinant Rhesus Macaque TAPBP Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	TAPBP-8610Z	Recombinant Zebrafish TAPBP	Mammalian Cell	His		Inquiry
Chicken	TAPBP-4512C	Recombinant Chicken TAPBP	Mammalian Cell	His		Inquiry
Chicken	TAPBP-3274C	Recombinant Chicken TAPBP	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TAPBP Related Articles
TAPBP Related Research Area

TAPBP involved in several pathways and played different roles in them. We selected most pathways TAPBP participated on our site, such as Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAPBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Antigen processing and presentation	RFXAP;KLRC1;HLA-E;TAP2;HLA-DOB;HSPA1A;CD8A;KLRD1;HLA-DRB4

TAPBP has several biochemical functions, for example, MHC class I protein binding, TAP1 binding, TAP2 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAPBP itself. We selected most functions TAPBP had, and list some proteins which have the same functions with TAPBP. You can find most of the proteins on our site.

Function	Related Protein
MHC class I protein binding	BCAP31;VCP;Pilrb1;ATP5B;ATP5A1;LILRB1;DERL1;CD244;TAP1
TAP1 binding	TAPBP;TAP2;HLA-F;TAP1
TAP2 binding	TAPBP;TAP1;HLA-F
peptide antigen binding	TAPBP;H2-Q10;MHC1ZFA;HLA-DRB5;HLA-G;MHC1UXA2;DHCR24;HLA-DPA1;TAP1
peptide antigen-transporting ATPase activity	TAP2;TAPBP
protein binding	SNX18;OLIG1;LBP;SEPT2;IKBIP;PTPRR;MCL1;ADAM22;APBB1
unfolded protein binding	CDC37;PPIA;RUVBL2;HSPA5;DNAJB2;HSPA2;RP2;CALR3;HSPA1B

TAPBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAPBP here. Most of them are supplied by our site. Hope this information will be useful for your research of TAPBP.

TAP1; TAP2

Hulpke, S; Baldauf, C; et al. Molecular architecture of the MHC I peptide-loading complex: one tapasin molecule is essential and sufficient for antigen processing. FASEB JOURNAL 26:5071-5080(2012).

Rizvi, SM; Raghavan, M; et al. Mechanisms of Function of Tapasin, a Critical Major Histocompatibility Complex Class I Assembly Factor. TRAFFIC 11:332-347(2010).

MHC Class I

MHC Class II

T Cell Antigen Recognition