tbxas1
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  • Official Full Name
  • thromboxane A synthase 1 (platelet)
  • Background
  • This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • TBXAS1; thromboxane A synthase 1 (platelet); thromboxane A synthase 1 (platelet, cytochrome P450, subfamily V); thromboxane-A synthase; CYP5; CYP5A1; cytochrome P450; family 5; subfamily A; polypeptide 1; THAS; TS; TXAS; TXS; Cytochrome P450 5A1; FLJ52771; GHOSAL; THAS_HUMAN; Thromboxane A synthase 1 platelet cytochrome P450 subfamily V; TXA synthase; OTTHUMP00000211927; OTTHUMP00000211928; OTTHUMP00000211929; OTTHUMP00000211930; OTTHUMP00000211931; platelet, cytochrome P450, subfamily V; cytochrome P450, family 5, subfamily A, polypeptide 1; thromboxane; BDPLT14
Cat.#:TBXAS1-3146HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TBXAS1, GST-tagged
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Cat.#:TBXAS1-3147HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TBXAS1, GST-tagged
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Cat.#:TBXAS1-3148HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TBXAS1, MYC/DDK-tagged
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Cat.#:TBXAS1-3149HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TBXAS1, MYC/DDK-tagged
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Cat.#:TBXAS1-8081HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TBXAS1 protein, His & T7-tagged
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Cat.#:TBXAS1-16537MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TBXAS1 Protein
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Cat.#:TBXAS1-5979RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TBXAS1 Protein
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Cat.#:TBXAS1-1007CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TBXAS1 Protein, His-tagged
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Cat.#:TBXAS1-11646ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TBXAS1
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Cat.#:TBXAS1-1196HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TBXAS1 293 Cell Lysate
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Involved Pathway

TBXAS1 involved in several pathways and played different roles in them. We selected most pathways TBXAS1 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBXAS1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
DPEP1; PTGES2; CYP2J6; PLA2G5; CYP2C70; PLA2G4C; CYP4A11; CYP2C55; ALOX5B.2; PTGESL
Metabolic pathways
IMPDH1A; PLA2G4C; HGD; GCDHA; OLAH; B3GNT1; GCDHB; NDUFAB1; NDUFB4; TKTB
Platelet activation
ROCK2; MYL12A; TLN1; VAMP8; P2RY1; ITPR3; STIM1; ITGB3; PRKCI; RHOA

Protein Function

TBXAS1 has several biochemical functions, for example, guanyl-nucleotide exchange factor activity, protein binding, thromboxane A2 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TBXAS1 itself. We selected most functions TBXAS1 had, and list some proteins which have the same functions with TBXAS1. You can find most of the proteins on our site.
Function
Related Protein
Function guanyl-nucleotide exchange factor activity
Related Protein RASGRP2; DOCK1; RALGDS; ARHGEF4; SH2D3CB; DENND1C; RIC8A; ARHGEF39; SH2D3A; ARHGEF7B
Function protein binding
Related Protein GADD45GIP1; NPHP4; MARCKSL1; DDX55; KLC1; ARL6IP5; CCL11; MED7; SH2D3C; NCOR2
Function thromboxane A2 receptor activity
Related Protein TBXAS1; TBXA2R

Interacting Protein

TBXAS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBXAS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBXAS1.
q9wmx2-pro_0000037548

TBXAS1 Related Articles

Munoz, YC; Gomez, GI; et al. Dehydroepiandrosterone Prevents the Aggregation of Platelets Obtained from Postmenopausal Women with Type 2 Diabetes Mellitus through the Activation of the PKC/eNOS/NO Pathway. HORMONE AND METABOLIC RESEARCH 44:625-631(2012).
Matsui, Y; Amano, H; et al. Thromboxane A2 receptor signaling facilitates tumor colonization through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells. CANCER SCIENCE 103:700-707(2012).