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TCEB3

  • Official Full Name

    transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)

  • Overview

    This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
  • Synonyms

    TCEB3; transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); transcription elongation factor B (SIII), polypeptide 3 (110kD, elongin A); transcription elongation factor B polypeptide 3; SIII; TCEB3A; Ela1; Elo A; EloA; ELOA1_HUMAN; Elongin 110 kDa subunit; Elongin-A; ElonginA; RNA polymerase II transcription factor SIII subunit A1; SIII p110; TCEB 3; Transcription elongation factor B (SIII) polypeptide 3 (110kD); Transcription elongation factor B (SIII) polypeptide 3; Transcription elongation factor B alpha subunit; OTTHUMP00000002990;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TCEB3-1751HCL Recombinant Human TCEB3 cell lysate N/A
Human TCEB3-3797H Recombinant Human TCEB3 protein, His-tagged E.coli His 1-400 aa
Mouse TCEB3-16552M Recombinant Mouse TCEB3 Protein Mammalian Cell His
Mouse TCEB3-9076M Recombinant Mouse TCEB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TCEB3-9076M-B Recombinant Mouse TCEB3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TCEB3-10472Z Recombinant Zebrafish TCEB3 Mammalian Cell His
Chicken TCEB3-2594C Recombinant Chicken TCEB3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

TCEB3 involved in several pathways and played different roles in them. We selected most pathways TCEB3 participated on our site, such as Disease, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCEB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DiseaseGPC6;RNF43;CPSF6;KREMEN1;LRRFIP1;CDC37;TNKS;NUP50;SUPT5H
Formation of HIV elongation complex in the absence of HIV TatCDK9;SUPT5H;TCEA1;PSTPIP2;WHSC2;SSRP1;TCEB3;TH1L;CTDP1
Formation of HIV-1 elongation complex containing HIV-1 TatTCEA1;SUPT5H;ELL;SSRP1;RDBP;TCEB3;CTDP1;SUPT4H1;CDK9
Formation of RNA Pol II elongation complexELL;TCEA1;CCNT2A;SSRP1;TH1L;CDK9;NELFE;GM3258;CTDP1
Gene ExpressionDCP1B;ZNF74;SESN3;ZNF562;WHSC2;FARS2;COX16;NR1H3;PRDM7
HIV InfectionPSTPIP2;TAF1L;AP1S1;PSIP1;ELL;AP1B1;CHMP4B;NMT2;CHMP4C
HIV Life CycleCHMP4B;ELL;CDK9;RCC1;SSRP1;TCEB3;PDCD6IP;VPS37A;PSIP1
HIV Transcription ElongationTCEB3;SSRP1

TCEB3 has several biochemical functions, for example, DNA binding, protein binding, contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TCEB3 itself. We selected most functions TCEB3 had, and list some proteins which have the same functions with TCEB3. You can find most of the proteins on our site.

Function Related Protein
DNA bindingAKAP8L;NR2F6A;KDM2AA;HOXB8B;FOXJ1;RAD54B;HIST1H47;ATXN1L;ZFP426
protein bindingC3;ATP5G1;SNX11;RGP1;CSTF1;GTF2IRD2;TSGA10IP;IRAK1;SPON1
contributes_to ubiquitin-protein transferase activityBARD1;KLHL30;BACH1;KLHL40A;TCEB3;KLHDC7A;TCEB1B;KLHL32;FBXL3

TCEB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCEB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCEB3.

PLK4; FLJ13057; KRT40; HOMEZ; CEP57L1; FAM9B

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