tenc1
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  • Official Full Name
  • tensin like C1 domain containing phosphatase (tensin 2)
  • Background
  • The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
  • Synonyms
  • TENC1; tensin like C1 domain containing phosphatase (tensin 2); tensin like C1 domain containing phosphatase; tensin-like C1 domain-containing phosphatase; C1 TEN; KIAA1075; tensin 2; TNS2; tensin-2; tensin like C1 domain-containing phosphatase; C1 domain
Cat.#:TENC1-16638MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TENC1 Protein
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Involved Pathway

TENC1 involved in several pathways and played different roles in them. We selected most pathways TENC1 participated on our site, such as PodNet: protein-protein interactions in the podocyte, XPodNet - protein-protein interactions in the podocyte expanded by STRING, which may be useful for your reference. Also, other proteins which involved in the same pathway with TENC1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PodNet: protein-protein interactions in the podocyte
LIMS2; DDN; SDK1; FRAS1; TENC1; CMIP; FAM65A
XPodNet - protein-protein interactions in the podocyte expanded by STRING
PKD1; ZFP423; MICALL2; ARHGAP33; SMARCD3; CARF; CHD1L; ARHGAP32; GMCL1; KCP

Protein Function

TENC1 has several biochemical functions, for example, 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity, IDP phosphatase activity, JUN kinase phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TENC1 itself. We selected most functions TENC1 had, and list some proteins which have the same functions with TENC1. You can find most of the proteins on our site.
Function
Related Protein
Function 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity
Related Protein PTPRQ; SGPP2; SACM1LB; PXYLP1; SACM1L; NT5DC3; SACM1LA; CTDSPL2B; CTDSPL2A; TENC1
Function IDP phosphatase activity
Related Protein PXYLP1; SACM1LA; SACM1L; SGPP2; PTPRQ; NT5DC3; CTDSPL2A; SACM1LB; CTDSPL2B; TENC1
Function JUN kinase phosphatase activity
Related Protein PXYLP1; SGPP2; SACM1L; PTPRQ; CTDSPL2B; NT5DC3; CTDSPL2A; DUSP19; TENC1; SACM1LB
Function MAP kinase tyrosine/serine/threonine phosphatase activity
Related Protein DUSP10; PTPRQ; DUSP8A; NT5DC3; SACM1LA; DUSP18; DUSP16; DUSP4; DUSP9; DUSP6
Function NADP phosphatase activity
Related Protein PTPRQ; PXYLP1; SACM1LB; NT5DC3; CTDSPL2B; CTDSPL2A; SGPP2; SACM1LA; TENC1; SACM1L
Function hydrolase activity
Related Protein DPYSL5A; HELZ; PTPRQ; INPPL1A; SMG6; TMEM62; FAHD2B; NOTUM1B; USP43; CPD
Function inositol bisphosphate phosphatase activity
Related Protein NT5DC3; SACM1LA; CTDSPL2B; CTDSPL2A; SACM1L; SACM1LB; PTPRQ; TENC1; SGPP2; INPP5K
Function inositol phosphate phosphatase activity
Related Protein SGPP2; OCRL; TENC1; CTDSPL2B; CTDSPL2A; SACM1LA; SACM1LB; SACM1L; PTPRQ; NT5DC3
Function inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity
Related Protein SACM1LA; PXYLP1; CTDSPL2B; CTDSPL2A; NT5DC3; SACM1LB; ITPK1; TENC1; SGPP2; PTPRQ
Function inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
Related Protein NT5DC3; PXYLP1; TENC1; PTPRQ; SACM1LA; CTDSPL2B; SGPP2; CTDSPL2A; SACM1LB; SACM1L
Function inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity
Related Protein SACM1L; TENC1; CTDSPL2A; PTPRQ; SACM1LA; CTDSPL2B; NT5DC3; ITPK1; SACM1LB; SGPP2
Function inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity
Related Protein CTDSPL2A; PTPRQ; SGPP2; TENC1; NT5DC3; CTDSPL2B; ITPK1; PXYLP1; SACM1LB; SACM1LA
Function inositol-1,3,4-trisphosphate 1-phosphatase activity
Related Protein PXYLP1; SACM1L; TENC1; CTDSPL2B; CTDSPL2A; PTPRQ; SGPP2; NT5DC3; SACM1LB; INPP1
Function inositol-1,3,4-trisphosphate 4-phosphatase activity
Related Protein CTDSPL2A; PTPRQ; SACM1LB; NT5DC3; TENC1; SACM1L; PXYLP1; SGPP2; CTDSPL2B; SACM1LA
Function inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
Related Protein PTPRQ; NT5DC3; TENC1; SGPP2; CTDSPL2B; PXYLP1; SACM1LB; CTDSPL2A; SACM1L; SACM1LA
Function inositol-3,4-bisphosphate 4-phosphatase activity
Related Protein SACM1LB; NT5DC3; SACM1LA; CTDSPL2B; CTDSPL2A; SGPP2; PTPRQ; SACM1L; PXYLP1; TENC1
Function inositol-4,5-bisphosphate 5-phosphatase activity
Related Protein SACM1LB; CTDSPL2B; PXYLP1; SGPP2; PTPRQ; NT5DC3; SACM1LA; TENC1; CTDSPL2A; SACM1L
Function kinase binding
Related Protein GFAP; PRPSAP1; SRC; FAS; PER1; CTNNB1; RPS3; CDC37; MIDN; CEBPB
Function metal ion binding
Related Protein FGD; APLF; GALNT18A; NR6A1A; CPPED1; HPDL; DPF2L; FGD3; CYP2C54; DRL
Function phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity
Related Protein TENC1; CTDSPL2A; PTPRQ; SACM1L; CTDSPL2B; NT5DC3; SACM1LA; PXYLP1; SACM1LB; SGPP2
Function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
Related Protein MTMR1; PXYLP1; TENC1; MTMR1B; MTM1; PTPRQ; MTMR1A; CTDSPL2B; SACM1LB; SGPP2
Function phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
Related Protein CTDSPL2A; SACM1LA; SACM1L; TENC1; SACM1LB; FIG4; PIKFYVE; NT5DC3; SGPP2; PXYLP1
Function phosphatidylinositol-4-phosphate phosphatase activity
Related Protein CTDSPL2A; SGPP2; TENC1; NT5DC3; PXYLP1; SACM1L; CTDSPL2B; PTPRQ; SACM1LB; FIG4
Function phosphohistidine phosphatase activity
Related Protein SACM1LB; NT5DC3; PTPRQ; SACM1L; TENC1; PXYLP1; PHPT1; CTDSPL2B; LHPP; MINPP1
Function phosphoprotein phosphatase activity
Related Protein PHPT1; PTPREB; SSH2; PTPN2B; PTPN11A; PPM1LA; PPM1LB; PPP5C; PPM1BB; ACP2
Function protein kinase binding
Related Protein MAML1; DLG1; B4GALT1; RFFL; FAM83A; RNF138; SLC12A7; AGTR1A; NPR1; DNAJC3
Function protein tyrosine/serine/threonine phosphatase activity
Related Protein DUSP14; DUSP18; CDC14C; DUSP4; DUSP16; PTENB; DUSP11; LRP8; PTP4A2A; NT5DC3
Function protein tyrosine/threonine phosphatase activity
Related Protein SACM1LB; NT5DC3; CTDSPL2B; DUSP19; SACM1LA; DUSP4; SGPP2; DUSP2; TENC1; PTPRQ
Function receptor binding
Related Protein FGF18A; H2-Q10; Ifnl2; LRRC4B; SRC; PTK2AB; CXCL10; RASA1; CD58; SERPINE2
Function transmembrane receptor protein phosphatase activity
Related Protein SGPP2; CTDSPL2A; CTDSPL2B; PTPRQ; NT5DC3; SACM1LB; SACM1LA; TENC1; SACM1L; PXYLP1

Interacting Protein

TENC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TENC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TENC1.
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TENC1 Related Articles

Karere, GM; Glenn, JP; et al. Identification of candidate genes encoding an LDL-C QTL in baboons. JOURNAL OF LIPID RESEARCH 54:1776-1785(2013).
Uchio-Yamada, K; Sawada, K; et al. Tenc1-Deficient Mice Develop Glomerular Disease in a Strain-Specific Manner. NEPHRON EXPERIMENTAL NEPHROLOGY 123:22-33(2013).
Dieterich, LC; Mellberg, S; et al. Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGF beta 2 in vascular abnormalization. JOURNAL OF PATHOLOGY 228:378-390(2012).
Chen, LH; Liu, CD; et al. H-1, N-15 and C-13 chemical shift assignments of the SH2 domain of human tensin2 (TENC1). BIOMOLECULAR NMR ASSIGNMENTS 5:211-214(2011).