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TFAP2A

  • Official Full Name

    transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

  • Overview

    The AP2 proteins are normally expressed in ectodermally derived vertebrate tissues where they are necessary for normal growth and development. The factors have also been implicated in the control of cell proliferation, viral transformation, and oncogenesis. AP2 seems to play in important role in human breast cancer. AP2 alpha is the only AP2 protein required for early morphogenesis of the lens vesicle. AP2 beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia
  • Synonyms

    TFAP2A; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); AP2TF, TFAP2, transcription factor AP 2 alpha (activating enhancer binding protein 2 alpha); transcription factor AP-2-alpha; AP 2; AP2-alpha; activator protein 2; AP-;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|Myc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TFAP2A-27355TH Recombinant Human TFAP2A Wheat Germ N/A 107 amino acids
Human TFAP2A-144H Recombinant Human TFAP2A Mammalian Cell His
Human TFAP2A-664HCL Recombinant Human TFAP2A lysate HEK293 N/A
Human TFAP2A-3351H Recombinant Human TFAP2A protein, His-tagged E.coli His 79-431 aa
Human TFAP2A-649H Recombinant Human TFAP2A Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TFAP2A-2176H Recombinant Human TFAP2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TFAP2A-1480H Recombinant Human TFAP2A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TFAP2A-2176H-B Recombinant Human TFAP2A Protein Pre-coupled Magnetic Beads HEK293
Human TFAP2A-402HFL Active Recombinant Full Length Human TFAP2A Protein, C-Flag-tagged Mammalian cells Flag
Mouse Tfap2a-6374M Recombinant Mouse Tfap2a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TFAP2A-2591M Recombinant Mouse TFAP2A Protein (1-437 aa), His-Myc-tagged E.coli His/Myc 1-437 aa
Zebrafish TFAP2A-9570Z Recombinant Zebrafish TFAP2A Mammalian Cell His
Chicken TFAP2A-6651C Recombinant Chicken TFAP2A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

TFAP2A involved in several pathways and played different roles in them. We selected most pathways TFAP2A participated on our site, such as Caspase cascade in apoptosis, Corticotropin-releasing hormone, Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFAP2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Caspase cascade in apoptosisCASP4;SATB1;LMNB1;NUMA1;CASP2;DFFA;CRADD;ACTA1;DIABLO
Corticotropin-releasing hormoneIVL;TFAP2A;TRIM28;JUNB;CRHR1;KRT1;JUND;CYP21A2;CRHR2
Neural Crest DifferentiationTFAP2A;FOXD3;OLIG2;LHX1;SOX10;PRTG;HEY2;DLX5;TXLNB
Wnt Signaling Pathway NetPathMARK2;SOX1;CRYBB2;SALL1;PAX2;TFAP2A;ROR2;HIPK2;TCF4

TFAP2A has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFAP2A itself. We selected most functions TFAP2A had, and list some proteins which have the same functions with TFAP2A. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingMYBL2;DLX4;ETV6;ZFP536;TCF3A;NRF1;MAX;FOXL2;TBX3
RNA polymerase II core promoter sequence-specific DNA bindingTFAP2B;MTF1;SMAD5;PAX8;STAT6;EGR1;TP53;PAX6;NFIL3
RNA polymerase II transcription factor activity, sequence-specific DNA bindingFOXB1B;FOXQ1;MEF2A;FOXD2;AHR2;JUN;FOXO4;ATF4B1;TFE3A
chromatin bindingNFIA;BAHD1;MSL1A;TRPS1;NFKB1;REST;NONO;ING5;GATA2
core promoter proximal region sequence-specific DNA bindingSP3;GATA3;CXXC1;SMAD3;ZFP516;DMRT2;CREBBP;SMAD4;DMRTA2
protein bindingSCNN1D;FAM129A;CTAG1A;NFATC4;NFKBIA;ELK3;RNF126;KCNMA1;NME7
protein dimerization activityMXD1;HER1;ATOH8;NPAS4A;MESP1;AHR2;FIGLA;OLIG1;ATOH1B
protein homodimerization activityLRRC41;RABEP1;TYMS;MASP1;TRPM8;VPS25;MAP3K10;FLT3;TRIM9
sequence-specific DNA bindingRHOXF1;ZBTB4;NKX2-8;HOXA13A;NKX3-1;POU2F1;ZNF238;TCF7L1A;CREB3L3A
transcription coactivator activityGTF2A1L;TAF1;PSMC3;PRDM16;MED1;ACTL6B;TAF5L;ASXL1;CBFB
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific bindingFOSL2;FOS;CREB3;CLOCK;ARNTL2;FOSL1;FOSL1A;FOSB;RBPJL
transcription factor bindingHIF1A;ESR1;NKX2;FOXF2;HDAC4;PRKDC;CREBBP;UBE2I;GATA2
transcription regulatory region DNA bindingBCL11AB;CREB3L1;PRDM5;YAP1;AHR;TFEB;SOX6;ERBB4;IKZF1
transcription regulatory region sequence-specific DNA bindingNFE2L2;NFE2L1;NR5A1A;ATF3;PSPC1;BAHD1;FOXJ1;SUV39H2;SOX12
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingPOU1F1;POU2F2;RUNX2;BATF;ETV6;FOXL2;HEYL;PAX5;GMEB1
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingRELA;AEBP2;PROX2;CUX2;KLF17;EN1;HAND1;SP3;NKX3-2

TFAP2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFAP2A here. Most of them are supplied by our site. Hope this information will be useful for your research of TFAP2A.

UBE2I; NPM1; MKRN3; GSTO2; EP300

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