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TFAP2B

Official Full Name

transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Overview

This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with;other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and;suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members;differ in their expression patterns and binding affinity for different promoters. This protein functions as both a;transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting;that this gene functions in the differentiation of neural crest cell derivatives.
Synonyms

TFAP2B; transcription factor AP-2 beta (activating enhancer binding protein 2 beta); transcription factor AP 2 beta (activating enhancer binding protein 2 beta); transcription factor AP-2-beta; AP2 B; Activating enhancer binding protein 2 beta; AP 2B; AP2B; AP2beta; MGC21381; OTTHUMP00000039925; TFAP 2B; Transcription factor AP 2 beta; Transcription factor AP2 beta; AP2-beta; OTTHUMP00000016595; activating enhancer-binding protein 2-beta; AP-2B; AP2-B;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TFAP2B-3193H	Recombinant Human TFAP2B, GST-tagged	E.coli	GST	C-term-350aa	$319 / 25ug
Human	TFAP2B-586H	Recombinant Human TFAP2B Protein, His-tagged	E.coli	His		Inquiry
Zebrafish	TFAP2B-2570Z	Recombinant Zebrafish TFAP2B	Mammalian Cell	His		Inquiry
Zebrafish	TFAP2B-3056Z	Recombinant Zebrafish TFAP2B	Mammalian Cell	His		Inquiry
Chicken	TFAP2B-6457C	Recombinant Chicken TFAP2B	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

TFAP2B involved in several pathways and played different roles in them. We selected most pathways TFAP2B participated on our site, such as Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFAP2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Neural Crest Differentiation	PHOX2B;HEY2;PRTG;MYB;ZIC1;MIA;CTBP2;OLIG2;OLIG1

TFAP2B has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TFAP2B itself. We selected most functions TFAP2B had, and list some proteins which have the same functions with TFAP2B. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	SSH2B;AGFG1;POLR2C;PML;HIST1H2BJ;ZFP354A;ZFAND5B;NABP1A;ATXN1L
RNA polymerase II core promoter sequence-specific DNA binding	H3F3B;SP1;TFAP2A;RUNX2;STAT5A;TRP53;YAP1;HEYL;MAZ
RNA polymerase II transcription coactivator activity	MED12;HYAL2;CREBBP;TBX20;SOX12;MKL1B;SOX11;POU3F1;RERE
RNA polymerase II transcription corepressor activity	SIN3A;NFIB;HEYL;RBBP8;SIN3AA;TBX18;HDGF;HDAC1;TLE1
RNA polymerase II transcription factor activity, sequence-specific DNA binding	FOXJ1;BHLHE40;FOXA;SPI1;SOX21;ETV5B;MAZ;SP3A;OVOL3
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	NAIP1;RPS6KA1;PRDX3;VIL1;BIRC7;PRDX5;XIAP;GAS6;TNFSF14
enhancer sequence-specific DNA binding	KLF7B;LMO4;MYT1;FOXN4;GATA2;LDB1;KLF6A;GATA1;TFAP2B
protein binding	TPSAB1;PDHX;SYNE3;LGI1;SIK2;C1QTNF1;UBAP2L;TBATA;ZNF843
protein dimerization activity	PPP3CB;SRFB;HER3;AHR2;HER11;ASCL1A;ARNTL1B;STK3;HIF3A
protein heterodimerization activity	PRMT8;SYCP3;NAE1;VOX;PDZD7;SMAD4;PEF1;CREB3L3;TOP2B
protein homodimerization activity	SETMAR;NETO2;SDCBP;ENO2;CRYBB2;IL17F;AXIN1;CPNE1;ANO6
sequence-specific DNA binding	CHES1;TFCP2L1;TEFB;ALX4B;MAFK;RORAB;PBX3B;CAMTA1;PNX
transcription coactivator activity	RAP2C;ATF2;SIX3;MED16;SOX10;NACA;MAGED1;ZSCAN1;FHL5
transcription corepressor activity	ERF;SKOR1B;E2F6;YAP1;TDP2;PBXIP1;MNT;RARA;HSBP1
transcription factor activity, RNA polymerase II core promoter sequence-specific	HEY2;TFAP2B;PAX7;MEF2C;MAX;NKX3;HEY1;SMAD3;HEYL
transcription factor activity, sequence-specific DNA binding	ZKSCAN3;NOTCH1;STAT3;ZNF571;TFDP1B;NANOG;HMGA1B;ALS2CR8;ZIC3
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	POU3F2;ZFAT;DLX5;TXK;TRP63;HMGA2;NR3C1;MEOX2;DLX3

TFAP2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFAP2B here. Most of them are supplied by our site. Hope this information will be useful for your research of TFAP2B.

CITED2; UBE2I; HIST1H2AC; VPS11